This work summarizes and puts in an overall perspective studies done within the compact muon solenoid (CMS) concerning the discovery potential for squarks and gluinos, sleptons, charginos and neutralinos, supersymmetric (SUSY) dark matter, lightest Higgs, sparticle mass determination methods and the detector design optimization in view of SUSY searches. It represents the status of our understanding of these subjects as of summer 1997. As a benchmark we used the minimal supergravity-inspired supersymmetric standard model (mSUGRA) with a stable lightest supersymmetric particle (LSP). Discovery of supersymmetry at the large hadron collider should be relatively straightforward. It may occur through the observation of large excesses of events in missing ET plus jets, or with one or more isolated leptons. An excess of trilepton events or isolated dileptons with missing ET, exhibiting a characteristic signature in the l+l− invariant mass distribution, could also be the first manifestation of SUSY production. Squarks and gluinos can be discovered for masses in excess of 2 TeV. Charginos and neutralinos can be discovered from an excess of events in dilepton or trilepton final states. Inclusive searches can give early indications from their copious production in squark and gluino cascade decays. Indirect evidence for sleptons can also be obtained from inclusive dilepton studies. Isolation requirements and a jet veto would allow detection of both the direct chargino/neutralino production and the directly produced sleptons. Squark and gluino production may also represent a copious source of Higgs bosons through cascade decays. The lightest SUSY Higgs h → b may be reconstructed with a signal/background ratio of order 1 thanks to hard cuts on ETmiss justified by escaping LSPs. The LSP of SUSY models with conserved R-parity represents a very good candidate for cosmological dark matter. The region of parameter space where this is true is well covered by our searches, at least for tanβ = 2. If supersymmetry exists at the electroweak scale, it could hardly escape detection in CMS and the study of supersymmetry will form a central part of our physics program.
Frequency combs are having a broad impact on science and technology because they provide a way to coherently link radio/microwave-rate electrical signals with optical-rate signals derived from lasers and atomic transitions. Integrating these systems on a photonic chip would revolutionize instrumentation, time keeping, spectroscopy, navigation, and potentially create new mass-market applications. A key element of such a system-on-a-chip will be a mode-locked comb that can be self-referenced. The recent demonstration of soliton mode locking in crystalline and silicon nitride microresonators has provided a way to both mode lock and generate femtosecond time-scale pulses. Here, soliton mode locking is demonstrated in high-Q silica resonators. The resonators produce low-phase-noise soliton pulse trains at readily detectable pulse rates—two essential properties for the operation of frequency combs. A method for the long-term stabilization of the solitons is also demonstrated, and is used to test the theoretical dependence of the comb power, efficiency, and soliton existence power on the pulse width. The influence of the Raman process on the soliton existence power and efficiency is also observed. The resonators are microfabricated on silicon chips and feature reproducible modal properties required for soliton formation. A low-noise and detectable pulse rate soliton frequency comb on a chip is a significant step towards a fully integrated frequency comb system.
Following the recent theory of f(Q) gravity, we continue to investigate the possible existence of wormhole geometries, where Q is the non-metricity scalar. Recently, the non-metricity scalar and the corresponding field equations have been studied for some spherically symmetric configurations in Mustafa (Phys Lett B 821:136612, 2021) and Lin and Zhai (Phys Rev D 103:124001, 2021). One can note that field equations are different in these two studies. Following Lin and Zhai (2021), we systematically study the field equations for wormhole solutions and found the violation of null energy conditions in the throat neighborhood. More specifically, considering specific choices for the f(Q) form and for constant redshift with different shape functions, we present a class of solutions for static and spherically symmetric wormholes. Our survey indicates that wormhole solutions could not exist for specific form function f(Q)=Q+αQ2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f(Q)= Q+ \alpha Q^2$$\end{document}. To summarize, exact wormhole models can be constructed with violation of the null energy condition throughout the spacetime while being ρ≥0\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\rho \ge 0$$\end{document} and vice versa.
Autophagy and migrasome formation constitute critical cellular mechanisms for maintaining cellular homeostasis, however, their potential compensatory interplay remains poorly understood. In this study, we identify VPS39, a core component of the HOPS complex, as a molecular switch coordinating these processes. Genetic ablation of VPS39 not only impairs autophagic flux but also triggers cell migration through RhoA/Rac1 GTPases upregulation, consequently facilitating migrasome formation. Using super-resolution microscopy, we further demonstrate that migrasomes serve as an alternative disposal route for damaged mitochondria during VPS39-induced autophagy impairment, revealing a novel stress adaptation mechanism. Our work establishes a previously unrecognized autophagy-migrasome axis and provides direct visual evidence of organelle quality control via migrasomal extrusion. These findings position VPS39-regulated pathway switching as a potential therapeutic strategy for neurodegenerative diseases characterized by autophagy dysfunction.
Formulating quantitative and predictive models for tissue development requires consideration of the complex, stochastic gene expression dynamics, its regulation via cell-to-cell interactions, and cell proliferation. Including all of these processes into a practical mathematical framework requires complex expressions that are difficult to interpret and apply. We construct a simple theory that incorporates intracellular stochastic gene expression dynamics, signaling chemicals that influence these dynamics and mediate cell-cell interactions, and cell proliferation and its accompanying differentiation. Cellular states (genetic and epigenetic) are described by a Waddington vector field that allows for non-gradient dynamics (cycles, entropy production, loss of detailed balance) which is precluded in Waddington potential landscape representations of gene expression dynamics. We define an epigenetic fitness landscape that describes the proliferation of different cell types, and elucidate how this fitness landscape is related to Waddington's vector field. We illustrate the applicability of our framework by analyzing two model systems: an interacting two-gene differentiation process and a spatiotemporal organism model inspired by planaria.
Understanding the interactions between cells and the extracellular matrix (ECM) during collective cell invasion is crucial for advancements in tissue engineering, cancer therapies, and regenerative medicine. This study focuses on the roles of contact guidance and ECM remodelling in directing cell behaviour, with a particular emphasis on exploring how differences in cell phenotype impact collective cell invasion. We present a computationally tractable two-dimensional hybrid model of collective cell migration within the ECM, where cells are modelled as individual entities and collagen fibres as a continuous tensorial field. Our model incorporates random motility, contact guidance, cell-cell adhesion, volume filling, and the dynamic remodelling of collagen fibres through cellular secretion and degradation. Through a comprehensive parameter sweep, we provide valuable insights into how differences in the cell phenotype, in terms of the ability of the cell to migrate, secrete, degrade, and respond to contact guidance cues from the ECM, impacts the characteristics of collective cell invasion.
Background Q-methodology is an approach to studying complex issues of human ‘subjectivity’. Although this approach was developed in the early twentieth century, the value of Q-methodology in healthcare was not recognised until relatively recently. The aim of this review was to scope the empirical healthcare literature to examine the extent to which Q-methodology has been utilised in healthcare over time, including how it has been used and for what purposes. Methods A search of three electronic databases (Scopus, EBSCO-CINAHL Complete, Medline) was conducted. No date restriction was applied. A title and abstract review, followed by a full-text review, was conducted by a team of five reviewers. Included articles were English-language, peer-reviewed journal articles that used Q-methodology (both Q-sorting and inverted factor analysis) in healthcare settings. The following data items were extracted into a purpose-designed Excel spreadsheet: study details (e.g., setting, country, year), reasons for using Q-methodology, healthcare topic area, participants (type and number), materials (e.g., ranking anchors and Q-set), methods (e.g., development of the Q-set, analysis), study results, and study implications. Data synthesis was descriptive in nature and involved frequency counting, open coding and the organisation by data items. Results Of the 2,302 articles identified by the search, 289 studies were included in this review. We found evidence of increased use of Q-methodology in healthcare, particularly over the last 5 years. However, this research remains diffuse, spread across a large number of journals and topic areas. In a number of studies, we identified limitations in the reporting of methods, such as insufficient information on how authors derived their Q-set, what types of analyses they performed, and the amount of variance explained. Conclusions Although Q-methodology is increasingly being adopted in healthcare research, it still appears to be relatively novel. This review highlight commonalities in how the method has been used, areas of application, and the potential value of the approach. To facilitate reporting of Q-methodological studies, we present a checklist of details that should be included for publication.
Very low frequency communication systems (3 kHz–30 kHz) enable applications not feasible at higher frequencies. However, the highest radiation efficiency antennas require size at the scale of the wavelength (here, >1 km), making portable transmitters extremely challenging. Facilitating transmitters at the 10 cm scale, we demonstrate an ultra-low loss lithium niobate piezoelectric electric dipole driven at acoustic resonance that radiates with greater than 300x higher efficiency compared to the previous state of the art at a comparable electrical size. A piezoelectric radiating element eliminates the need for large impedance matching networks as it self-resonates at the acoustic wavelength. Temporal modulation of this resonance demonstrates a device bandwidth greater than 83x beyond the conventional Bode-Fano limit, thus increasing the transmitter bitrate while still minimizing losses. These results will open new applications for portable, electrically small antennas. Designing high radiation efficiency antennas for portable transmitters in low frequency communication systems remains a challenge. Here, the authors report on using piezoelectricity to more efficiently radiate while achieving a bandwidth eighty three times higher than the passive Bode-Fano limit.