The holographic superconductor is the holographic dual of superconductors. We recently identified the dual Ginzburg-Landau (GL) theory for a class of bulk 5-dimensional holographic superconductors (arXiv:2207.07182 [hep-th]). However, the result is the strong coupling limit or the large-$N_c$ limit. A natural question is how the dual GL theory changes at finite coupling. We identify the dual GL theory for a minimal holographic superconductor at finite coupling (Gauss-Bonnet holographic superconductor), where numerical coefficients are obtained exactly. The GL parameter $κ$ increases at finite coupling, namely the system approaches a more Type-II superconductor like material. We also point out two potential problems in previous works: (1) the "naive" AdS/CFT dictionary, and (2) the condensate determined only from the GL potential terms. As a result, the condensate increases at finite coupling unlike common folklore.
E. Ridruejo, Giselle Romero-Caími, M. Obregon
et al.
Hepatocellular carcinoma (HCC) represents 90% of liver tumors. Statins, may reduce the incidence of various tumors, including HCC. Antitumoral activities may be mediated by changes in transforming growth factor-beta (TGF-β1) and thyroid hormones (TH) regulation. INTRODUCTION AND AIM Hepatocellular carcinoma (HCC) represents 90% of liver tumors. Statins, may reduce the incidence of various tumors, including HCC. Antitumoral activities may be mediated by changes in transforming growth factor-beta (TGF-β1) and thyroid hormones (TH) regulation. Aim. The aim of our study is to establish the statins mechanism of action and the potential key molecules involved in an in vivo and in vitro HCC model. MATERIALS AND METHODS We used two models: in vivo (in rats) using diethylnitrosamine (DEN) and hexachlorobenzene (HCB) to develop HCC. We analyzed cell proliferation parameters (proliferating cel nuclear antigen, PCNA) and cholesterol metabolism (hydroxy-methylglutaryl-CoA reductase, HMGCoAR). In vitro (Hep-G2 cells) we evaluated the effects of different doses of Atorvastatin (AT) and Simvastatin (SM) on HCB induced proliferation and analyzed proliferative parameters, cholesterol metabolism, TGF-β1 mRNA, c-Src and TH levels. RESULTS In vivo, we observed that cell proliferation significantly increased as well as cholesterol serum levels in rats treated with HCB. In vitro, we observed the same results on PCNA as in vivo. The statins prevented the increase in HMG-CoAR mRNA levels induced by HCB, reaching levels similar to controls at maximum doses: AT (30 μM), and SM (20 μM). Increases in PCNA, TGF-β1, and pc-Src, and decreases in deiodinase I mRNA levels induced by HCB were not observed when cells were pre-treated with AT and SM at maximum doses. CONCLUSION Statins can prevent the proliferative HCB effects on Hep-G2 cells. TGF-β1, c-Src and TH may be the statins molecular targets in hepatocarcinogenesis.
This is an introductory article about Markov Chain Monte Carlo (MCMC) simulation for pedestrians. Actual simulation codes are provided, and necessary practical details, which are skipped in most textbooks, are shown. The second half is written for hep-th and hep-lat audience. It explains specific methods needed for simulations with dynamical fermions, especially supersymmetric Yang-Mills. The examples include QCD and matrix integral, in addition to SYM.
Meson spectroscopy at finite gauge coupling – whereat any perturbative QCD computation would break down – and finite number of colors, from a top–down holographic string model, has thus far been entirely missing in the literature. This paper fills this gap. Using the delocalized type IIA SYZ mirror (with SU(3) structure) of the holographic type IIB dual of large-N thermal QCD of Mia et al. (Nucl Phys B 839:187. arXiv:0902.1540 [hep-th], 2010) as constructed in Dhuria and Misra (JHEP 1311:001. arXiv:1306.4339 [hep-th], 2013) at finite coupling and number of colors ($$N_c =$$Nc= number of $$D5(\overline{D5}$$D5(D5¯)-branes wrapping a vanishing two-cycle in the top–down holographic construct of Mia et al. (Nucl Phys B 839:187. arXiv:0902.1540 [hep-th], 2010) = $$\mathcal{O}(1)$$O(1) in the IR in the MQGP limit of Dhuria and Misra (JHEP 1311:001. arXiv:1306.4339 [hep-th], 2013) at the end of a Seiberg-duality cascade), we obtain analytical (not just numerical) expressions for the vector and scalar meson spectra and compare our results with previous calculations of Sakai and Sugimoto (Prog Theor Phys 113:843. doi:10.1143/PTP.113.843. arXiv:hep-th/0412141, 2005) and Dasgupta et al. (JHEP 1507:122. doi:10.1007/JHEP07(2015)122. arXiv:1409.0559 [hep-th], 2015), and we obtain a closer match with the Particle Data Group (PDG) results of Olive et al. (Particle Data Group) (Chin Phys C 38:090001, 2014). Through explicit computations, we verify that the vector and scalar meson spectra obtained by the gravity dual with a black hole for all temperatures (small and large) are nearly isospectral with the spectra obtained by a thermal gravity dual valid for only low temperatures; the isospectrality is much closer for vector mesons than scalar mesons. The black-hole gravity dual (with a horizon radius smaller than the deconfinement scale) also provides the expected large-N suppressed decrease in vector meson mass with increase of temperature.
In this work, we study the propagators of matter fields within the framework of the refined Gribov–Zwanziger theory, which takes into account the effects of the Gribov copies in the gauge-fixing quantization procedure of Yang–Mills theory. In full analogy with the pure gluon sector of the refined Gribov–Zwanziger action, a non-local long-range term in the inverse of the Faddeev–Popov operator is added in the matter sector. Making use of the recent BRST-invariant formulation of the Gribov–Zwanziger framework achieved in Capri et al. (Phys Rev D 92(4):045039, 2015), (Phys Rev D 94(2):025035, 2016), (Phys Rev D 93(6):065019, 2016), (arXiv:1611.10077 [hep-th]), Pereira et al. (arXiv:1605.09747 [hep-th]),the propagators of scalar and quark fields in the adjoint and fundamental representations of the gauge group are worked out explicitly in the linear covariant, Curci–Ferrari and maximal Abelian gauges. Whenever lattice data are available, our results exhibit good qualitative agreement.