Hasil untuk "Surgery"

C. Cummings

no abstract required for this manuscript type. References: 20 maximum, including the article discussed. Figures/tables: 2 maximum. Description: Commentaries, upon Editor’s invitation, discuss a paper published in a specific issue and should set the problems addressed by the paper in the wider context of the field. Proposals for Commentaries may be submitted; however, in this case authors should only send an outline of the proposed paper for initial consideration

Robert C. Gorman, Matthew J Gillespie, J. Gorman

I. Welters

A. Frolkis, J. Dykeman, M. Negrón et al.

S. Urba, M. Orringer, A. Turrisi et al.

Abhilash Jain, J. Nanchahal

It really isn't just as simple as looks and money, say Abhilash Jain and Jagdeep Nanchahal

D. Kelsen, R. Ginsberg, T. Pajak et al.

D. Green

A. Fowler, T. Ahmad, M. Phull et al.

S. Brethauer, Julie J. Kim, M. Chaar et al.

J. Havens, Allan B. Peetz, Woo S. Do et al.

Nuria Senar, Stavros Makrodimitris, Michel H. Hof et al.

Detection of minimal residual disease (MRD) in cancer patients after surgery can provide an early marker for disease recurrence and guide subsequent treatment decisions. Accurate and sensitive estimation of tumour burden after cancer surgery may be obtained through liq- uid biopsies, measuring circulating tumour DNA (ctDNA) using, for example, mutation-based Variant Allele Frequency (VAF) values. However, to be applicable to all patients this ei- ther requires tumour-informed, patient-specific mutation panels or sensitive, tumour-agnostic genome-wide measurements. We propose a solution that accounts for patient-specific charac- teristics in genome-wide screens. For that, we introduce a bivariate deconvolution model to estimate tumour proportion from circulating cell-free DNA (cfDNA) methylation profiles of patients before and after surgery. The observations are modelled as a convolution of two bivariate latent variables, corresponding to tumour and background signals, mixed by the tumour proportion at each measurement. This bivariate approach links pre- and post-surgery measurements improving estimation of the tumour proportion after surgery, when the tumour signal is potentially very weak, or absent. We approximate likelihood of the convolution through a discretisation of the bivariate density for each latent variable into a two-dimensional grid for each pair of observations which allows for fast maximum likelihood estimation. We evaluate the predictive performance of the estimated post-surgery tumour proportions based on cfDNA methylation against available mutation-based VAF values in one-year recurrence-free survival.

Andrew C. Yuan, Alexander Cowtan, Zhiyang He et al.

Quantum code surgery offers a flexible, low-overhead framework for executing logical measurements within quantum error-correcting codes. It encompasses several fault-tolerant logical computation schemes, including parallel surgery, universal adapters and fast surgery, and serves as the key primitive in extractor architectures. The efficiency of these schemes crucially depends on constructing low-overhead ancilla systems for measuring arbitrary logical operators in general quantum Low-Density Parity-Check (qLDPC) codes. In this work, we introduce a method to construct an ancilla system of qubit size $O(W \log W)$ to measure an arbitrary logical Pauli operator of weight $W$ in any qLDPC stabilizer code. This new construction immediately reduces the asymptotic overhead across various quantum code surgery schemes.

Marc Kegel, Paula Truöl

In this short note, we prove that every closed, oriented, connected 3-manifold arises as Dehn surgery along a braid positive link.

Marc Kegel, Lisa Piccirillo

Distinct knots K, K' can sometimes share a common p/q-framed Dehn surgery. A folk conjecture held that for a fixed pair of knots, this can occur for at most one value of p/q. We disprove this conjecture by constructing pairs of distinct knots K,K' that have common Dehn surgeries for four distinct slopes. We also construct non-isotopic Legendrian knots K,K' that have contactomorphic contact (+1)-and (-1)-surgeries, disproving an analogous conjecture in contact geometry.

Angel Alois Osorio Manyari, Azucena Lirio Armas Alvarez, Joel Davis Osorio Manyari et al.

Background: The effect of metabolic surgery on long-term diabetes remission in Asian patients with a body mass index (BMI) < 30 kg/m2 has not been widely reported. Methods: We conducted a systematic review of the PubMed and Cochrane Library databases from inception to June 2024. All clinical trials and observational studies involving the effect of metabolic surgery in Asian patients with type 2 diabetes mellitus and BMI <30 kg/m2 were considered. The quality of the studies was assessed using the Newcastle-Ottawa scale. Results: Of the 1175 studies screened, 21 studies (11 prospective and 10 retrospective), including 1005 patients, were selected. Only one study had a control group. The longest follow-up was 60 months. The results showed significant improvement in glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2-h plasma glucose (2hPG), homeostasis model assessment for insulin resistance index (HOMA-IR), fasting C-peptide, triglycerides, total cholesterol, and a reduction in the use of oral hypoglycemic agents/insulin at 12, 24, 36, and 60 months after metabolic surgery. The most common surgical complications observed were anemia (2.1 %–33 %), marginal ulcer (4.2 %–17.3 %), gastrointestinal bleeding (1.9 %–12 %), anastomotic leak (2.1 %–3.5 %), anastomotic stenosis (2.1 %–3.5 %), reoperation (1.18 %), and a mortality rate of zero. Conclusions: Long-term diabetes remission, along with improvements in HbA1c, 2hPG, FBG, and HOMA-IR, with an acceptable rate of complications, was observed in Asian patients with BMI <30 kg/m2 after metabolic surgery. Future research with controlled studies should focus on preoperative patient selection criteria beyond just the BMI cutoff.

Zuo-cheng Yang, Bo-wen Xue, Xin-yu Song et al.

ObjectivesThis study aimed to elucidate the influences of 1p/19q co-deletion on structural connectivity alterations in patients with dominant hemisphere insular diffuse gliomas.MethodsWe incorporated 32 cases of left insular gliomas and 20 healthy controls for this study. Using diffusion MRI, we applied correlational tractography, differential tractography, and graph theoretical analysis to explore the potential connectivity associated with 1p/19q co-deletion.ResultsThe study revealed that the quantitative anisotropy (QA) of key deep medial fiber tracts, including the anterior thalamic radiation, superior thalamic radiation, fornix, and cingulum, had significant negative associations with 1p/19q co-deletion (FDR = 4.72 × 10–5). These tracts are crucial in maintaining the integrity of brain networks. Differential analysis further supported these findings (FWER-corrected p &lt; 0.05). The 1p/19q non-co-deletion group exhibited significantly higher clustering coefficients (FDR-corrected p &lt; 0.05) and reduced betweenness centrality (FDR-corrected p &lt; 0.05) in regions around the tumor compared to HC group. Graph theoretical analysis indicated that non-co-deletion patients had increased local clustering and decreased betweenness centrality in peritumoral brain regions compared to co-deletion patients and healthy controls (FDR-corrected p &lt; 0.05). Additionally, despite not being significant through correction, patients with 1p/19q co-deletion exhibited lower trends in weighted average clustering coefficient, transitivity, small worldness, and global efficiency, while showing higher tendencies in weighted path length compared to patients without the co-deletion.ConclusionThe findings of this study underline the significant role of 1p/19q co-deletion in altering structural connectivity in insular glioma patients. These alterations in brain networks could have profound implications for the neural functionality in patients with dominant hemisphere insular gliomas.

P. Małczak, M. Pisarska, Major Piotr et al.

Enhanced recovery after surgery (ERAS) protocol is well established in many surgical disciplines and leads to a decrease in the length of hospital stay and morbidity. Multimodal protocols have also been introduced to bariatric surgery. This review aims to evaluate the current literature on ERAS in obesity surgery and to conduct a meta-analysis of primary and secondary outcomes. MEDLINE, Embase, Scopus and Cochrane Library were searched for eligible studies. Key journals were hand-searched. We analysed data up to May 2016. Eligible studies had to contain four described ERAS protocol elements. The primary outcome was the length of hospital stay; the secondary outcomes included overall morbidity, specific complications, mortality, readmissions and costs. Random effect meta-analyses were undertaken. The initial search yielded 1151 articles. Thorough evaluation resulted in 11 papers, which were analysed. The meta-analysis of the length of stay presented a significant reduction standard mean difference (Std. MD) = −2.39 (−3.89, −0.89), p = 0.002. The analysis of overall morbidity, specific complications and Clavien-Dindo classification showed no significant variations among the study groups. ERAS protocol in bariatric surgery leads to the reduction of the length of hospital stay while maintaining no or low influence on morbidity.