We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.
The article reveals the prerequisites, course and consequences of the peasant uprising that took place in the Chernivtsi suburb of Rosh in June 1871 as a reaction to the introduction of a new rent for grazing livestock. The research was carried out within the framework of the “RESTORY” project (HORIZONCL2-2023-HERITAGE-01-№ 101132781), aimed at restoring cultural memory and local identity through the analysis of textual and oral sources. The relevance of the research is due to the need to rethink local manifestations of civil resistance in the social space of Bukovina beyond the romanticized idea of the “golden age” of the Austrian administration. The scientific novelty lies in the introduction into scientific circulation of a complex of previously unpublished archival documents that highlight a little-studied episode of local resistance to fiscal policy. Conclusions. At the heart of the conflict is the attempt of the Chernivtsi city authorities to establish a rent for the use of pastures, which contradicted the centuries-old customs of free grazing, which the residents of Roshi considered their natural right. The introduction of this fee in conditions of poverty, high tax liabilities and the consequences of the famine of 1865 was perceived as unfair and repressive. The refusal of residents to pay the fee, mass disobedience and confrontation with police and military units testified to a high level of social tension in the community. The material is of interest to researchers of the social history of Austria-Hungary, local public movements, as well as for studying the mechanisms of fiscal pressure in the imperial peripheries
History of medicine. Medical expeditions, Social Sciences
Aytül Hadımlı, Emine Serap Çağan, Sevil Güner
et al.
Objective: The aim of this study was to determine the validity and reliability of the ‘Cultural Beliefs about Weaning Scale’ among breastfeeding women in the Turkish population.Method: The data of the methodologically designed study were collected by snowball sampling using online method between November 2020 and August 2022. A total of 336 breastfeeding women with children aged 6 months-2 years participated in the study. Descriptive Characteristics Questionnaire and Cultural Beliefs about Weaning Scale were used to collect data. The scale consists of 49 items and 5 subscales. In the validity and reliability analyses of the scale, language, content and construct validity, explanatory and confirmatory factor analyses, internal consistency level and item-total score correlation were evaluated. Results: According to confirmatory factor analysis, 19 items in the original scale were removed from the scale due to low factor loadings and the remaining 30 items were found to be related to the 5-dimensional scale structure. In the factor analysis, the factor loadings of the scale items ranged between .36 and .86. The total Cronbach's Alpha Coefficient was found to be .89.Conclusion: It was determined that the Turkish form of the Mothers' Cultural Beliefs about Weaning Scale can be used as a measurement tool with acceptable validity and reliability results.
History of medicine. Medical expeditions, Miscellaneous systems and treatments
Although Vision Transformers (ViTs) have recently demonstrated superior performance in medical imaging problems, they face explainability issues similar to previous architectures such as convolutional neural networks. Recent research efforts suggest that attention maps, which are part of decision-making process of ViTs can potentially address the explainability issue by identifying regions influencing predictions, especially in models pretrained with self-supervised learning. In this work, we compare the visual explanations of attention maps to other commonly used methods for medical imaging problems. To do so, we employ four distinct medical imaging datasets that involve the identification of (1) colonic polyps, (2) breast tumors, (3) esophageal inflammation, and (4) bone fractures and hardware implants. Through large-scale experiments on the aforementioned datasets using various supervised and self-supervised pretrained ViTs, we find that although attention maps show promise under certain conditions and generally surpass GradCAM in explainability, they are outperformed by transformer-specific interpretability methods. Our findings indicate that the efficacy of attention maps as a method of interpretability is context-dependent and may be limited as they do not consistently provide the comprehensive insights required for robust medical decision-making.
Convolutional neural networks (CNNs) are widely used for high-stakes applications like medicine, often surpassing human performance. However, most explanation methods rely on post-hoc attribution, approximating the decision-making process of already trained black-box models. These methods are often sensitive, unreliable, and fail to reflect true model reasoning, limiting their trustworthiness in critical applications. In this work, we introduce SoftCAM, a straightforward yet effective approach that makes standard CNN architectures inherently interpretable. By removing the global average pooling layer and replacing the fully connected classification layer with a convolution-based class evidence layer, SoftCAM preserves spatial information and produces explicit class activation maps that form the basis of the model's predictions. Evaluated on three medical datasets, SoftCAM maintains classification performance while significantly improving both the qualitative and quantitative explanation compared to existing post-hoc methods. Our results demonstrate that CNNs can be inherently interpretable without compromising performance, advancing the development of self-explainable deep learning for high-stakes decision-making. The code is available at https://github.com/kdjoumessi/SoftCAM
Cross-domain few-shot medical image segmentation (CD-FSMIS) offers a promising and data-efficient solution for medical applications where annotations are severely scarce and multimodal analysis is required. However, existing methods typically filter out domain-specific information to improve generalization, which inadvertently limits cross-domain performance and degrades source-domain accuracy. To address this, we present Contrastive Graph Modeling (C-Graph), a framework that leverages the structural consistency of medical images as a reliable domain-transferable prior. We represent image features as graphs, with pixels as nodes and semantic affinities as edges. A Structural Prior Graph (SPG) layer is proposed to capture and transfer target-category node dependencies and enable global structure modeling through explicit node interactions. Building upon SPG layers, we introduce a Subgraph Matching Decoding (SMD) mechanism that exploits semantic relations among nodes to guide prediction. Furthermore, we design a Confusion-minimizing Node Contrast (CNC) loss to mitigate node ambiguity and subgraph heterogeneity by contrastively enhancing node discriminability in the graph space. Our method significantly outperforms prior CD-FSMIS approaches across multiple cross-domain benchmarks, achieving state-of-the-art performance while simultaneously preserving strong segmentation accuracy on the source domain.
Artifacts pose a significant challenge in medical imaging, impacting diagnostic accuracy and downstream analysis. While image-based approaches for detecting artifacts can be effective, they often rely on preprocessing methods that can lead to information loss and high-memory-demand medical images, thereby limiting the scalability of classification models. In this work, we propose the use of implicit neural representations (INRs) for image quality assessment. INRs provide a compact and continuous representation of medical images, naturally handling variations in resolution and image size while reducing memory overhead. We develop deep weight space networks, graph neural networks, and relational attention transformers that operate on INRs to achieve image quality assessment. Our method is evaluated on the ACDC dataset with synthetically generated artifact patterns, demonstrating its effectiveness in assessing image quality while achieving similar performance with fewer parameters.
Medical Vision-Language Models (MVLMs) have achieved par excellence generalization in medical image analysis, yet their performance under noisy, corrupted conditions remains largely untested. Clinical imaging is inherently susceptible to acquisition artifacts and noise; however, existing evaluations predominantly assess generally clean datasets, overlooking robustness -- i.e., the model's ability to perform under real-world distortions. To address this gap, we first introduce MediMeta-C, a corruption benchmark that systematically applies several perturbations across multiple medical imaging datasets. Combined with MedMNIST-C, this establishes a comprehensive robustness evaluation framework for MVLMs. We further propose RobustMedCLIP, a visual encoder adaptation of a pretrained MVLM that incorporates few-shot tuning to enhance resilience against corruptions. Through extensive experiments, we benchmark 5 major MVLMs across 5 medical imaging modalities, revealing that existing models exhibit severe degradation under corruption and struggle with domain-modality tradeoffs. Our findings highlight the necessity of diverse training and robust adaptation strategies, demonstrating that efficient low-rank adaptation when paired with few-shot tuning, improves robustness while preserving generalization across modalities.
With the advancements in self-supervised learning (SSL), transformer-based computer vision models have recently demonstrated superior results compared to convolutional neural networks (CNNs) and are poised to dominate the field of artificial intelligence (AI)-based medical imaging in the upcoming years. Nevertheless, similar to CNNs, unveiling the decision-making process of transformer-based models remains a challenge. In this work, we take a step towards demystifying the decision-making process of transformer-based medical imaging models and propose Token Insight, a novel method that identifies the critical tokens that contribute to the prediction made by the model. Our method relies on the principled approach of token discarding native to transformer-based models, requires no additional module, and can be applied to any transformer model. Using the proposed approach, we quantify the importance of each token based on its contribution to the prediction and enable a more nuanced understanding of the model's decisions. Our experimental results which are showcased on the problem of colonic polyp identification using both supervised and self-supervised pretrained vision transformers indicate that Token Insight contributes to a more transparent and interpretable transformer-based medical imaging model, fostering trust and facilitating broader adoption in clinical settings.
Mrs. Dr. Soghra Azarmi (1914-1973) is one of the most influential female doctors in Iran’s contemporary history. She was the first pathologist and the pioneer of the cytology database, making a significant impact on the lives of many women suffering from cancer. Various experiences marked her life, and she navigated through the stages of career progression with genuine merit. Dr. Soghra Azarmi initiated her secondary education in Hamedan, located in western Iran. Following a teaching period, she pursued her medical studies at Tehran University. Later, she ventured to the United States, where she worked at Women’s Hospital in Chicago, Illinois. There she pursued her studies in Pathology. Subsequently, she obtained a research opportunity in Melbourne, Australia, and furthered her studies in cytology at Johns Hopkins University in Baltimore. Upon returning to Iran, Dr. Soghra Azarmi joined the National Cancer Society, where she played a crucial role in saving the lives of numerous cancer patients. This research gives an introduction to the pathology department at Tehran University and subsequently reports the scientific and research journey of the esteemed professor in the pathology department.
Medicine, History of medicine. Medical expeditions
Semi-supervised medical image segmentation (SSMIS) has emerged as a promising solution to tackle the challenges of time-consuming manual labeling in the medical field. However, in practical scenarios, there are often domain variations within the datasets, leading to derivative scenarios like semi-supervised medical domain generalization (Semi-MDG) and unsupervised medical domain adaptation (UMDA). In this paper, we aim to develop a generic framework that masters all three tasks. We notice a critical shared challenge across three scenarios: the explicit semantic knowledge for segmentation performance and rich domain knowledge for generalizability exclusively exist in the labeled set and unlabeled set respectively. Such discrepancy hinders existing methods from effectively comprehending both types of knowledge under semi-supervised settings. To tackle this challenge, we develop a Semantic & Domain Knowledge Messenger (S&D Messenger) which facilitates direct knowledge delivery between the labeled and unlabeled set, and thus allowing the model to comprehend both of them in each individual learning flow. Equipped with our S&D Messenger, a naive pseudo-labeling method can achieve huge improvement on six benchmark datasets for SSMIS (+7.5%), UMDA (+5.6%), and Semi-MDG tasks (+1.14%), compared with state-of-the-art methods designed for specific tasks.
Jingyu Guo, Christos Matsoukas, Fredrik Strand
et al.
In multi-view medical diagnosis, deep learning-based models often fuse information from different imaging perspectives to improve diagnostic performance. However, existing approaches are prone to overfitting and rely heavily on view-specific features, which can lead to trivial solutions. In this work, we introduce Random Token Fusion (RTF), a novel technique designed to enhance multi-view medical image analysis using vision transformers. By integrating randomness into the feature fusion process during training, RTF addresses the issue of overfitting and enhances the robustness and accuracy of diagnostic models without incurring any additional cost at inference. We validate our approach on standard mammography and chest X-ray benchmark datasets. Through extensive experiments, we demonstrate that RTF consistently improves the performance of existing fusion methods, paving the way for a new generation of multi-view medical foundation models.
Medical data often exhibits long-tail distributions with heavy class imbalance, which naturally leads to difficulty in classifying the minority classes (i.e., boundary regions or rare objects). Recent work has significantly improved semi-supervised medical image segmentation in long-tailed scenarios by equipping them with unsupervised contrastive criteria. However, it remains unclear how well they will perform in the labeled portion of data where class distribution is also highly imbalanced. In this work, we present ACTION++, an improved contrastive learning framework with adaptive anatomical contrast for semi-supervised medical segmentation. Specifically, we propose an adaptive supervised contrastive loss, where we first compute the optimal locations of class centers uniformly distributed on the embedding space (i.e., off-line), and then perform online contrastive matching training by encouraging different class features to adaptively match these distinct and uniformly distributed class centers. Moreover, we argue that blindly adopting a constant temperature $τ$ in the contrastive loss on long-tailed medical data is not optimal, and propose to use a dynamic $τ$ via a simple cosine schedule to yield better separation between majority and minority classes. Empirically, we evaluate ACTION++ on ACDC and LA benchmarks and show that it achieves state-of-the-art across two semi-supervised settings. Theoretically, we analyze the performance of adaptive anatomical contrast and confirm its superiority in label efficiency.
Medical anomaly detection is a crucial yet challenging task aimed at recognizing abnormal images to assist in diagnosis. Due to the high-cost annotations of abnormal images, most methods utilize only known normal images during training and identify samples deviating from the normal profile as anomalies in the testing phase. Many readily available unlabeled images containing anomalies are thus ignored in the training phase, restricting the performance. To solve this problem, we introduce one-class semi-supervised learning (OC-SSL) to utilize known normal and unlabeled images for training, and propose Dual-distribution Discrepancy for Anomaly Detection (DDAD) based on this setting. Ensembles of reconstruction networks are designed to model the distribution of normal images and the distribution of both normal and unlabeled images, deriving the normative distribution module (NDM) and unknown distribution module (UDM). Subsequently, the intra-discrepancy of NDM and inter-discrepancy between the two modules are designed as anomaly scores. Furthermore, we propose a new perspective on self-supervised learning, which is designed to refine the anomaly scores rather than detect anomalies directly. Five medical datasets, including chest X-rays, brain MRIs and retinal fundus images, are organized as benchmarks for evaluation. Experiments on these benchmarks comprehensively compare a wide range of anomaly detection methods and demonstrate that our method achieves significant gains and outperforms the state-of-the-art. Code and organized benchmarks are available at https://github.com/caiyu6666/DDAD-ASR.
Supervised machine learning provides state-of-the-art solutions to a wide range of computer vision problems. However, the need for copious labelled training data limits the capabilities of these algorithms in scenarios where such input is scarce or expensive. Self-supervised learning offers a way to lower the need for manually annotated data by pretraining models for a specific domain on unlabelled data. In this approach, labelled data are solely required to fine-tune models for downstream tasks. Medical image segmentation is a field where labelling data requires expert knowledge and collecting large labelled datasets is challenging; therefore, self-supervised learning algorithms promise substantial improvements in this field. Despite this, self-supervised learning algorithms are used rarely to pretrain medical image segmentation networks. In this paper, we elaborate and analyse the effectiveness of supervised and self-supervised pretraining approaches on downstream medical image segmentation, focusing on convergence and data efficiency. We find that self-supervised pretraining on natural images and target-domain-specific images leads to the fastest and most stable downstream convergence. In our experiments on the ACDC cardiac segmentation dataset, this pretraining approach achieves 4-5 times faster fine-tuning convergence compared to an ImageNet pretrained model. We also show that this approach requires less than five epochs of pretraining on domain-specific data to achieve such improvement in the downstream convergence time. Finally, we find that, in low-data scenarios, supervised ImageNet pretraining achieves the best accuracy, requiring less than 100 annotated samples to realise close to minimal error.
Chinese Spelling Correction (CSC) is gaining increasing attention due to its promise of automatically detecting and correcting spelling errors in Chinese texts. Despite its extensive use in many applications, like search engines and optical character recognition systems, little has been explored in medical scenarios in which complex and uncommon medical entities are easily misspelled. Correcting the misspellings of medical entities is arguably more difficult than those in the open domain due to its requirements of specificdomain knowledge. In this work, we define the task of Medical-domain Chinese Spelling Correction and propose MCSCSet, a large scale specialist-annotated dataset that contains about 200k samples. In contrast to the existing open-domain CSC datasets, MCSCSet involves: i) extensive real-world medical queries collected from Tencent Yidian, ii) corresponding misspelled sentences manually annotated by medical specialists. To ensure automated dataset curation, MCSCSet further offers a medical confusion set consisting of the commonly misspelled characters of given Chinese medical terms. This enables one to create the medical misspelling dataset automatically. Extensive empirical studies have shown significant performance gaps between the open-domain and medical-domain spelling correction, highlighting the need to develop high-quality datasets that allow for Chinese spelling correction in specific domains. Moreover, our work benchmarks several representative Chinese spelling correction models, establishing baselines for future work.
The study of G. Roerichs scientific heritage is at its beginning. An important basis of Roerichs many-sided scientific activities were his investigations during the expeditions in Asia. The longest, most dangerous and laborious among them was the Central Asiatic expedition of his father - N.K. Roerich. The goal of this article is to examine G.N. Roerichs activities on every stage of the Central Asiatic expedition, as well as G.N. Roerichs works, publishing the results of the expedition research. G.N. Roerich presented the basic results in his monograph Trails to Inmost Asia: Five years of exploration with the Roerich Central Asian Expedition published in English in USA in 1931. Roerichs description of North and Central Tibet is unique because the theocratic state in Tibet and nomad tribes, which Roerich had observed, are no more existing. Roerichs field investigations continued the historical tradition of Russian expeditions in Central Asia. It extended our scientific knowledge about the insufficiently known regions in Asia.
El presente artículo analiza el trabajo realizado por las Hijas de la Caridad de San Vicente de Paul en los hospitales de Chile durante el siglo XIX. En base a escritos originales de las vicentinas y reglamentos hospitalarios, postula que los cambios introducidos por dichas religiosas fueron fundamentales permitiendo que los hospitales fueran desligándose de la beneficencia colonial e ir adentrándose en los parámetros establecidos por la ciencia moderna.
History of scholarship and learning. The humanities, History of medicine. Medical expeditions