Spyridoula G. Farmaki, Dimitrios A. Exarchos, Vasileios Dracopoulos
et al.
Recent advances in nanotechnology have highlighted the transformative potential of carbon-based nanomaterials, such as carbon nanofibers, carbon nanotubes, and graphene, in cementitious systems. These materials have shown a remarkable ability to enhance the mechanical strength, fracture toughness, and overall functional performance of cementitious composites. Their nanoscale dimensions and exceptional intrinsic properties allow for effective stress bridging, crack arrest, and matrix densification. Despite these promising features, the current understanding remains limited, particularly regarding their application to concrete. Furthermore, literature lacks systematic, parallel evaluations of their respective effectiveness in improving both mechanical performance and long-term durability, as well as their potential to impart true multifunctionality to concrete structures. It is worth noting that significant and statistically significant improvements in fracture behavior were observed at specific nanofiller concentrations, suggesting strong potential for the material system in next-generation innovative infrastructure applications. Experimental results demonstrated that both CNTs and GNPs significantly enhanced the mechanical performance of concrete, with flexural strength increases of approximately 49% and 38%, and compressive strength improvements of 22% and 47%, respectively, at optimum contents of 0.6 wt.% CNTs and 0.8 wt.% GNPs. SEM analyses confirmed improved matrix densification and interfacial bonding at these concentrations, while higher dosages led to agglomeration and reduced performance. This gap highlights the need for targeted experimental studies to elucidate the structure-property relationships governing these advanced materials.
Aim or purpose: Commercially available barrier membranes for guided tissue regeneration (GTR) often lack suitable mechanical properties, controllable degradation rate, and sufficient bioactivity, which would lead to unsatisfied bone regeneration capacity, thereby being unable to fulfill the demands of oral clinical treatment. Materials and methods: The multifunctional biomimetic GTR membrane composed of a dense layer and a porous layer was fabricated by emulsion template method: The dense layer with a stable structure acts as an effective physical barrier preventing the soft tissue from invading the bone defect areas; The porous layer functionalized by the DP7-C/miR-26a complex would promote efficient bone regeneration by regulating immune microenvironment. The physicochemical characterization of membranes were measured by SEM, universal mechanical testing machine and UV-vis spectrophotometer. The in vitro bioactivities of macrophage polarization and BMSCs differentiation were evaluated through flow cytometry, Western blot, qPCR and immunofluorescence. The in vivo therapeutic efficacy was also validated by the rat periodontitis model through micro-CT analysis, H&E staining, and immunohistochemical. Results: The membrane possesses heterogeneous bilayer microstructures, strain maintenance ability, good degradation property, and well biocompatibility. In vitro, it redirected macrophages toward regenerative M2 polarization (CD206↑/TNF-α↓/IL-10↑) while potentiating BMSCs osteogenesis via upregulated RUNX2/OCN expression and accelerated mineralization. The micro-CT reconstruction confirmed significant mitigation of alveolar bone destruction in vivo. Conclusions: In this study, the multifunctional biomimetic GTR membrane was developed to achieve rapid and efficient bone regeneration in inflammatory microenvironment, providing new means for oral clinical treatment of inflammatory bone defects.
Automatic Baire property is a variant of the usual Baire property which is fulfilled for subsets of the Cantor space accepted by finite automata. We consider the family $\mathcal{A}$ of subsets of the Cantor space having the Automatic Baire property. In particular we show that not all finite subsets have the Automatic Baire property, and that already a slight increase of the computational power of the accepting device may lead beyond the class $\mathcal{A}$.
In this paper, we propose a novel normalized time-fractional susceptible–infected–removed (SIR) model that incorporates memory effects into epidemiological dynamics. The proposed model is based on a newly developed normalized time-fractional derivative, which is similar to the well-known Caputo fractional derivative but is characterized by the property that the sum of its weight function equals one. This unity property is crucial because it helps with evaluating how the fractional order influences the behavior of time-fractional differential equations over time. The normalized time-fractional derivative, with its unity property, provides an intuitive understanding of how fractional orders influence the SIR model’s dynamics and enables systematic exploration of how changes in the fractional order affect the model’s behavior. We numerically investigate how these variations impact the epidemiological dynamics of our normalized time-fractional SIR model and highlight the role of fractional order in improving the accuracy of infectious disease predictions. The appendix provides the program code for the model.
The integration of digital technology, particularly virtual reality, is proving to be a pivotal tool in preserving and sharing the rich cultural heritage found within Cave art sites. This article deliberates on the use and application of digital technology in the field of cave painting conservation that provides an authentic and effective method of Cave art preservation for the future. Employing advanced techniques of photogrammetry, terrestrial laser scanning, structured light scanning, and high-resolution photography can digitally preserve the intricate details of Cave art, while the utilization of humidity, temperature, and CO2 sensors may provide a comprehensive digital monitoring system to track the condition of Cave art over time. This paper deals with the evolving landscape of technologies and their application to safeguard Cave art from environmental degradation and anthropogenic factors. The digitization of cave art has the potential to accurately conserve a site if used in an effective manner while also allowing visitors to experience this art form in ways never before feasible. The application of advanced digital technology in cave art conservation is not merely a choice but a necessity, considering the impermanent nature of these paintings in their natural environment. This paper underscores the urgency and significance of leveraging digital tools to ensure the enduring legacy of Cave art, an example of how digital technologies, as they evolve, will play an increasingly essential role in the conservation and dissemination of our world’s extraordinary cultural heritage.
Quantum property preservation (QPP) is the problem of maintaining a target property of a quantum system for as long as possible. This problem arises naturally in the context of open quantum systems subject to decoherence. Here, we develop a general theory to formalize and analyze QPP. We characterize properties encoded as scalar functions of the system state that can be preserved time-locally via continuous control using smoothly varying, time-dependent control Hamiltonians. The theory offers an intuitive geometric interpretation involving the level sets of the target property and the stable and unstable points related to the noise channel. We present solutions for various noise channels and target properties, which are classified as trivially controllable, uncontrollable, or controllable. In the controllable scenario, we demonstrate the existence of control Hamiltonian singularities and breakdown times, beyond which property preservation fails. QPP via Hamiltonian control is complementary to quantum error correction, as it does not require ancilla qubits or rely on measurement and feedback. It is also complementary to dynamical decoupling, since it uses only smooth Hamiltonians without pulsing and works in the regime of Markovian open system dynamics. From the perspective of control theory, this work addresses the challenge of tracking control for open quantum systems.
AbstractThis chapter examines the progressive property school’s attempts to address property’s shortcomings, as it is one of the more recent critiques of the ownership model to have gained traction. The main characteristics of progressive property are described, and the contributions of prominent scholars are summarised in relation to virtue ethics, public trust and the common heritage of mankind. While noting that this school emerged in the specific cultural context of the US, and that its parameters are continuing to evolve, the chapter nevertheless outlines some conceptual limitations in progressive property thinking that have implications for developing a spatially just approach to property. The chapter concludes by reinforcing the importance of a legal geographical perspective when examining the law’s relationship with land.
Rowa Bakadlag, Georgia Limniatis, Gabriel Georges
et al.
Abstract Background P-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer drugs and targeted chemotherapeutics. However, paradoxically P-glycoprotein overexpressing drug resistant cells are “collaterally sensitive” to non-toxic drugs that stimulate its ATPase activity. Methods Cell viability assays were used to determine the effect of low concentrations of tamoxifen on the proliferation of multidrug resistant cells (CHORC5 and MDA-Doxo400), expressing P-gp, their parental cell lines (AuxB1 and MDA-MB-231) or P-gp-CRISPR knockout clones of AuxB1 and CHORC5 cells. Western blot analysis was used to estimate P-gp expression in different cell lines. Apoptosis of tamoxifen-induced cell death was estimated by flow cytometry using Annexin-V-FITC stained cells. Oxidative stress of tamoxifen treated cells was determined by measuring levels of reactive oxygen species and reduced thiols using cell-permeant 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) and 5,5-dithio-bis-(2-nitrobenzoic acid) DTNB, respectively. Results In this report, we show that P-gp-expressing drug resistant cells (CHORC5 and MDA-Doxo400) are collaterally sensitive to the anti-estrogen tamoxifen or its metabolite (4-hydroxy-tamoxifen). Moreover, P-gp-knockout clones of CHORC5 cells display complete reversal of collateral sensitivity to tamoxifen. Drug resistant cells exposed to low concentrations of tamoxifen show significant rise in reactive oxygen species, drop of reduced cellular thiols and increased apoptosis. Consistent with the latter, CHORC5 cells expressing high levels of human Bcl-2 (CHORC5-Bcl-2) show significant resistance to tamoxifen. In addition, the presence of the antioxidant N-acetylcysteine or P-gp ATPase inhibitor, PSC-833, reverse the collateral sensitivity of resistant cells to tamoxifen. By contrast, the presence of rotenone (specific inhibitor of mitochondria complex I) synergizes with tamoxifen. Conclusion This study demonstrates the use of tamoxifen as collateral sensitivity drug that can preferentially target multidrug resistant cells expressing P-gp at clinically achievable concentrations. Given the widespread use of tamoxifen in the treatment of estrogen receptor-positive breast cancers, this property of tamoxifen may have clinical applications in treatment of P-gp-positive drug resistant breast tumors. Graphical Abstract
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC). However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy. This study aims to evaluate the critical role of Siglec-10+ tumor-associated macrophages (TAMs) in regulating antitumor immunity and to explore the potential of the myeloid checkpoint Siglec-10 as an interventional target.Design Siglec-10+ TAMs were assessed based on immunohistochemistry on tumor microarrays and RNA-sequencing data. Flow cytometry, RNA sequencing, and single-cell RNA-sequencing analysis were employed to characterize the phenotypic and transcriptional features of Siglec-10+ TAMs and their impact on CD8+ T cell-mediated antitumor immunity. The effectiveness of Siglec-10 blockade, either alone or in combination with anti-programmed cell death 1 (PD-1), was evaluated using an ex vivo GC tumor fragment platform based on fresh tumor tissues.Results Siglec-10 was predominantly expressed on TAMs in GC, and associated with tumor progression. In Zhongshan Hospital cohort, Siglec-10+ TAMs predicted unfavorable prognosis (n=446, p<0.001) and resistance to adjuvant chemotherapy (n=331, p<0.001), which were further validated in exogenous cohorts. In the Samsung Medical Center cohort, Siglec-10+ TAMs demonstrated inferior response to pembrolizumab in GC (n=45, p=0.008). Furthermore, Siglec-10+ TAMs exhibited an immunosuppressive phenotype and hindered T cell-mediated antitumor immune response. Finally, blocking Siglec-10 reinvigorated the antitumor immune response and synergistically enhances anti-PD-1 immunotherapy in an ex vivo GC tumor fragment platform.Conclusions In GC, the myeloid checkpoint Siglec-10 contributes to the regulation of immunosuppressive property of TAMs and promotes the depletion of CD8+ T cells, ultimately facilitating immune evasion. Targeting Siglec-10 represents a potential strategy for immunotherapy in GC.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Dear Editor-in-Chief
On January 28, the city of Khoy (the northwest of Iran) was struck by a strong earthquake with a magnitude of 5.9 on the Richter scale at 21:44:44 and a depth of 7 km, X: 45.01 and Y: 38.05 (1). This earthquake occurred 117 kilometers from Urmia, the capital of the West Azerbaijan Province. Over 370,000 people were affected by this earthquake, which resulted in three deaths and more than 1,750 injuries. More than 70 villages in the area and the cities of Khoy and Firouraq were damaged to varying degrees (2).
A few days before the earthquake, a rumor circulated on the internet that there would be a strong earthquake on Saturday January 29th, followed by a magnitude 9 earthquake on February 16th. After the earthquake, many of affected people left their homes in the early hours and went to the cities of Salmas, Urmia, and Tabriz. In the quake-hit area, people took shelter in makeshift camps or tents near the destroyed homes.
Humanitarian aid arrived from all over the country and neighboring provinces to the affected area. Government organizations, military, religious bodies, associations, unions, and non-governmental organizations provided the basic needs and equipment needed by the people of the earthquake-affected area. However, the distribution of food and equipment among people affected by the earthquake was inappropriate. For instance, some donors were providing aid directly, essential drugs were not adequately supplied. Despite the large amount of aid sent, a distribution aid was concentrated in some areas and neglected in other areas, and some people did not yet manage to receive essential items such as food, blankets, tent heating equipment (3).
In Urmia, adequate services were provided in the camps established in the mosques. Health teams had a daily presence in the mosques, providing free medical and health services. The mosques were run by the Basij (volunteer mobilization force), or Mosque Council, with most help coming from donors and official and unofficial communications from the council. One notable thing was that earthquake victims tended to receive more than actually need medical and pharmaceutical services, as well as other services.
Some people were unwilling to leave their homes and settled in the makeshift camps for reasons such as fear of possible theft of their property from damaged houses. Due to rumors of a stronger earthquake on February 16th, those shelter in nearby cities did not want to return to the disaster area.
Iran is located on the earthquake fault line (4), and several faults in the northwest of the country activated in the past and caused devastating earthquakes such as the earthquakes with a magnitude of 5.4 on the Richter scale that occurred in the cities of Khoy and Salmas in 1900 and 1930 (5,6). Therefore, the occurrence of similar or stronger earthquakes in this area can be expected in the region in future (6,7). In general, observations show that the scale of destruction and damage does not exceed national and even provincial capabilities. However, one thing that is evident, despite the formation of numerous crisis preparedness committees before the earthquake, the lack of complete coordination in the calculation, as well as supply and distribution of the real basic needs among stakeholders in the crisis management scene is one of the main challenges.
Considering the occurrence of similar problems during similar natural disasters in the northwest region, it is suggested that policy makers focus more on the community context in disaster management. A model that can align the participation of government organizations, unions, and social groups can lead to more coordination in the proper distribution of aid and meeting the needs of the victims in the early days.
Evaluating the stray light cancellation performance of an optical system is an essential step in the search for superior optical systems. However, the existing evaluation methods, such as the Monte Carlo method and the ray tracing method, suffer from the problems of vast arithmetic and cumbersome processes. In this paper, a method for a rapid stray light performance evaluation model and quantitatively determining high-magnitude stray light outside the field of view are proposed by adopting the radiative transfer theory based on the scattering property of the bidirectional scattering distribution function (BSDF). Under the global coordinates, based on the derivation of the light vector variation relationship in the near-linear system, the specific structural properties of the off-axis reflective optical system, and the specular scattering properties, a fast quantitative evaluation model of the optical system’s stray light elimination capability is constructed. A loop nesting procedure was designed based on this model, and its validity was verified by an off-axis reflective optical system. It successfully fitted the point source transmittance (PST) curve in the range of specular radiation reception angles and quantitatively predicted the prominence due to incident stray light outside the field of view. This method does not require multiple software to work in concert and requires only 10<sup>–5</sup> orders of magnitude of computing time, which is suitable for the rapid stray light assessment and structural screening of off-axis reflective optical systems with a good symmetry. The method is promising for improving imaging radiation accuracy and developing lightweight space cameras with low stray light effects.
In this paper, we introduce the notion of the diagonal property and the weak point property for an ind-variety. We prove that the ind-varieties of higher rank divisors of integral slopes on a smooth projective curve have the weak point property. Moreover, we show that the ind-variety of $(1,n)$-divisors has the diagonal property and is a locally complete linear ind-variety and calculate its Picard group. Furthermore, we obtain that the Hilbert schemes of a curve associated to the good partitions of a constant polynomial satisfy the diagonal property. In the process of obtaining this, we provide the exact number of such Hilbert schemes up to isomorphism by proving that the multi symmetric products associated to two distinct partitions of a positive integer $n$ are not isomorphic.
Camilo Argoty, Alexander Berenstein, Nicolas Cuervo Ovalle
A complete theory $T$ has the Schröder-Bernstein property or simply the SB-property if any pair of elementarily bi-embeddable models are isomorphic. This property has been studied in the discrete first-order setting and can be seen as a first step towards classification theory. This paper deals with the SB-property on continuous theories. Examples of complete continuous theories that have this property include Hilbert spaces and any completion of the theory of probability algebras. We also study a weaker notion, the SB-property up to perturbations. This property holds if any two elementarily bi-embeddable models are isomorphic up to perturbations. We prove that the theory of Hilbert spaces expanded with a bounded self-adjoint operator has the SB-property up to perturbations of the operator and that the theory of atomless probability algebras with a generic automorphism have the SB-property up to perturbations of the automorphism. We also study how the SB-property behaves with respect to randomizations. Finally we prove, in the continuous setting, that if $T$ is a strictly stable theory then $T$ does not have the SB-property.
Muhammad Kamran, Nadeem Salamat, Riaz Hussain Khan
et al.
Phenol-formaldehyde resin has a wide range of moldings. The phenolic resin retains properties at the freezing point; hence, it is difficult to determine its age. However, it has immense consumption in manufacturing electrical equipment due to its insulating property. There are many types of topological indices such as degree-based topological indices, distance-based topological indices, etc. Topological indices correlate some physiochemical properties of chemical compounds. In this article, the degree-based topological indices of phenol-formaldehyde resin have been determined. Furthermore, the Revan index, hyper Revan index, modified Revan index, sum connectivity Revan index, harmonic Revan index, and inverse Revan index have been calculated.