Hasil untuk "Life"

Ivica Letunic, P. Bork

Abstract The Interactive Tree Of Life (https://itol.embl.de) is an online tool for the display, manipulation and annotation of phylogenetic and other trees. It is freely available and open to everyone. The current version introduces four new dataset types, together with numerous new features. Annotation options have been expanded and new control options added for many display elements. An interactive spreadsheet-like editor has been implemented, providing dataset creation and editing directly in the web interface. Font support has been rewritten with full support for UTF-8 character encoding throughout the user interface. Google Web Fonts are now fully supported in the tree text labels. iTOL v4 is the first tool which supports direct visualization of Qiime 2 trees and associated annotations. The user account system has been streamlined and expanded with new navigation options, and currently handles >700 000 trees from more than 40 000 individual users. Full batch access has been implemented allowing programmatic upload and export of trees and annotations.

C. Darwin

B. Langer, M. D. Certeau

Michel de Certeau’s The Practice of Everyday Life (1984) remains a cornerstone for rethinking urban space anthropologically. In this excerpt, De Certeau contrasts the abstract, panoramic vision of the city seen from above with the embodied, everyday acts of walking that resist totalization. His reflection highlights the gap between official representations of urban space and the lived practices that continually reinvent it — a key tension at the heart of anthropological approaches to urbanism.

David Furman, J. Campisi, E. Verdin et al.

Juliane Jung

H. Flemming, J. Wingender, U. Szewzyk et al.

Damian Szklarczyk, Andrea Franceschini, S. Wyder et al.

The many functional partnerships and interactions that occur between proteins are at the core of cellular processing and their systematic characterization helps to provide context in molecular systems biology. However, known and predicted interactions are scattered over multiple resources, and the available data exhibit notable differences in terms of quality and completeness. The STRING database (http://string-db.org) aims to provide a critical assessment and integration of protein–protein interactions, including direct (physical) as well as indirect (functional) associations. The new version 10.0 of STRING covers more than 2000 organisms, which has necessitated novel, scalable algorithms for transferring interaction information between organisms. For this purpose, we have introduced hierarchical and self-consistent orthology annotations for all interacting proteins, grouping the proteins into families at various levels of phylogenetic resolution. Further improvements in version 10.0 include a completely redesigned prediction pipeline for inferring protein–protein associations from co-expression data, an API interface for the R computing environment and improved statistical analysis for enrichment tests in user-provided networks.

E. Diener, Robert A Emmons, R. Larsen et al.

P. Blau

E. Goffman

N. Aaronson, S. Ahmedzai, B. Bergman et al.

A. Kasuya

T. Moffitt

D. Cox

J. Jacobs

D. Cox

R. Karasek, T. Theorell

A. Caspi, K. Sugden, T. Moffitt et al.

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

M. Scheier, C. Carver, Michael W. Bridges

Professor H. Herrman, H. Dr, UniversityofMelbourneAustralia . Murphy et al.