{"results":[{"id":"crossref_10.1371/journal.pone.0330520","title":"Phosphoproteomic profiling of feline mammary carcinoma: Insights into tumor grading and potential therapeutic targets","authors":[{"name":"Pruettha Aruvornlop"},{"name":"Sekkarin Ploypetch"},{"name":"Walasinee Sakcamduang"},{"name":"Sirintra Sirivisoot"},{"name":"Tanit Kasantikul"},{"name":"Sittiruk Roytrakul"},{"name":"Narumon Phaonakrop"},{"name":"Nlin Arya"}],"abstract":"Feline mammary carcinoma (FMC) is the most prevalent reproductive tumor in queens and is characterized by aggressive metastatic progression and short survival. Protein phosphorylation is a crucial process in cell regulation, with dysregulation linked to cancer progression, including human breast cancer. Although phosphoproteins have emerged as diagnostic and predictive markers in human breast cancer, knowledge remains limited on their role in FMC. In this study, the phosphoproteomic profiles of specimens for FMC grades 1 (n = 6), grade 2 (n = 11), grade 3 (n = 14), and normal controls (n = 6) were compared by phosphoprotein enrichment coupled with liquid chromatography–tandem mass spectrometry. Seventeen downregulated phosphoproteins were identified across all FMC grades, many of which have established roles in human breast cancer pathogenesis and prognosis. Serine/threonine–protein phosphatase was identified as a potential growth promoter and therapeutic target, while acid phosphatase, prostate, and ribonuclease L were identified as tumor suppressors. Furthermore, the ABC-type glutathione-S-conjugate transporter was associated with multidrug resistance. Protein kinase AMP-activated noncatalytic subunit gamma 3 was associated with increased breast cancer risk. In this study, it was also found to be associated with Ki-67 expression in FMC (p = 0.03). These phosphoproteins interacted with various proteins, immune checkpoint molecules, and chemotherapy drugs associated with mammary cancer in both human and feline species. Furthermore, proteins, such as butyrophilin subfamily 1 member A1, keratin, type I cytoskeletal 10, HECT domain E3 ubiquitin protein ligase 3, nuclear receptor binding SET domain protein 3, and stomatin-like 2, were identified and implicated in cancer progression and prognosis. This study is the first phosphoproteomic investigation of FMC, highlighting the interactions of relevant phosphoproteins with other proteins and chemotherapy drugs associated with both feline and human mammary cancers. The findings provide valuable insights for the identification of diagnostic and prognostic biomarkers and potential therapeutic targets in cats with mammary carcinoma.","source":"CrossRef","year":2025,"language":"en","subjects":null,"doi":"10.1371/journal.pone.0330520","url":"https://doi.org/10.1371/journal.pone.0330520","is_open_access":true,"published_at":"","score":69},{"id":"crossref_10.1016/j.actatropica.2024.107183","title":"Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)","authors":[{"name":"Somjit Chaiwattanarungruengpaisan"},{"name":"Metawee Thongdee"},{"name":"Nlin Arya"},{"name":"Weena Paungpin"},{"name":"Wanna Sirimanapong"},{"name":"Ladawan Sariya"}],"abstract":"","source":"CrossRef","year":2024,"language":"en","subjects":null,"doi":"10.1016/j.actatropica.2024.107183","url":"https://doi.org/10.1016/j.actatropica.2024.107183","is_open_access":true,"citations":3,"published_at":"","score":68.09},{"id":"crossref_10.23919/ofc49934.2023.10116373","title":"Statistical Properties of NLIN in Presence of PDL","authors":[{"name":"Ori Golani"},{"name":"David Dahan"}],"abstract":"","source":"CrossRef","year":2023,"language":"en","subjects":null,"doi":"10.23919/ofc49934.2023.10116373","url":"https://doi.org/10.23919/ofc49934.2023.10116373","is_open_access":true,"published_at":"","score":67},{"id":"crossref_10.3389/fvets.2022.1003673","title":"Case report: Mature extragonadal teratoma at the proximal part of the tail in a kitten","authors":[{"name":"Sirintra Sirivisoot"},{"name":"Naklop Siripara"},{"name":"Nlin Arya"},{"name":"Somporn Techangamsuwan"},{"name":"Anudep Rungsipipat"},{"name":"Tanit Kasantikul"}],"abstract":"An 8-month-old, intact male, domestic shorthair cat was referred for a mass on the proximal ventral part of the tail which had been found since the animal was born, and due to the presence of a linear fissure with rows of ectopic teeth, the veterinarian suspected that the mass had recently ruptured. Tail amputation was elected and the entire mass was successfully surgically excised. From the gross examination, this mass had an open cyst-like structure with a prominent area composed of hair, teeth, and bone. Histopathology revealed two components of germinal layers including hair follicles, adnexal tissue, neural tissue, teeth, muscle, fat, bone, and lymphatic vessels. The histopathological diagnosis was consistent to mature teratoma. Although, complete excision could not be definitively confirmed histologically, this kitten is currently well and has not developed any recurrent mass at the surgical site after 2 years of post-operation.","source":"CrossRef","year":2022,"language":"en","subjects":null,"doi":"10.3389/fvets.2022.1003673","url":"https://doi.org/10.3389/fvets.2022.1003673","is_open_access":true,"citations":7,"published_at":"","score":66.21000000000001},{"id":"crossref_10.1016/j.jcpa.2020.12.003","title":"Disseminated Haemophagocytic Histiocytic Sarcoma in an African Pygmy Hedgehog (Atelerix albiventris)","authors":[{"name":"Sirintra Sirivisoot"},{"name":"Nlin Arya"},{"name":"Matti Kiupel"},{"name":"Pemika Kaenchan"},{"name":"Wasana Buayam"},{"name":"Tanit Kasantikul"}],"abstract":"","source":"CrossRef","year":2021,"language":"en","subjects":null,"doi":"10.1016/j.jcpa.2020.12.003","url":"https://doi.org/10.1016/j.jcpa.2020.12.003","is_open_access":true,"citations":2,"published_at":"","score":65.06},{"id":"crossref_10.1109/jlt.2019.2894638","title":"NLIN Mitigation Using Turbo Equalization and an Extended Kalman Smoother","authors":[{"name":"Ori Golani"},{"name":"Meir Feder"},{"name":"Mark Shtaif"}],"abstract":"","source":"CrossRef","year":2019,"language":"en","subjects":null,"doi":"10.1109/jlt.2019.2894638","url":"https://doi.org/10.1109/jlt.2019.2894638","is_open_access":true,"citations":18,"published_at":"","score":63.54},{"id":"crossref_10.1109/jlt.2018.2820908","title":"Kalman-MLSE Equalization for NLIN Mitigation","authors":[{"name":"Ori Golani"},{"name":"Meir Feder"},{"name":"Mark Shtaif"}],"abstract":"","source":"CrossRef","year":2018,"language":"en","subjects":null,"doi":"10.1109/jlt.2018.2820908","url":"https://doi.org/10.1109/jlt.2018.2820908","is_open_access":true,"citations":18,"published_at":"","score":62.54},{"id":"arxiv_1708.06319","title":"Physical aspects of self-organization processes in composites. 2. The structure and interaction of inner boundaries","authors":[{"name":"Alexander Herega"}],"abstract":"A model of the oscillatory component of interaction of inner boundaries is studied; and the features of generation of the composite structure in interim asymptotics are considered. A model of a multiscale net of inner boundaries was used to obtain analytical expressions for calculating the force fields of the Sierpinski prefractal and its modifications.","source":"arXiv","year":2017,"language":"en","subjects":["nlin.AO"],"url":"https://arxiv.org/abs/1708.06319","pdf_url":"https://arxiv.org/pdf/1708.06319","is_open_access":true,"published_at":"2017-08-15T16:15:21Z","score":61},{"id":"arxiv_1609.06006","title":"Synchronization, Consensus of Complex Networks and their relationships","authors":[{"name":"Tianping Chen"}],"abstract":"In this paper, we focus on the topic Synchronization and consensus of Complex Networks and their relationships. It is revealed that two topics are closely relating to each other and all results given in \\cite{Li} can be obtained by the results in \\cite{Lu2006}.","source":"arXiv","year":2016,"language":"en","subjects":["nlin.AO","math.OC"],"url":"https://arxiv.org/abs/1609.06006","pdf_url":"https://arxiv.org/pdf/1609.06006","is_open_access":true,"published_at":"2016-09-20T03:11:20Z","score":60},{"id":"arxiv_1205.0817","title":"Bio-inspired Political Systems","authors":[{"name":"Nathalie Mezza-Garcia"}],"abstract":"In this paper I consider the necessity and the possibilities of engineering bio-inspired political systems. Systems capable of harnessing the complexity of the human social systems and their increasingly growing and diversifying interactions.","source":"arXiv","year":2012,"language":"en","subjects":["nlin.AO","physics.soc-ph"],"url":"https://arxiv.org/abs/1205.0817","pdf_url":"https://arxiv.org/pdf/1205.0817","is_open_access":true,"published_at":"2012-05-03T20:12:38Z","score":56},{"id":"arxiv_1102.4462","title":"Synchronization of the cardiac pacemaker model with delayed pulse-coupling","authors":[{"name":"Marat Akhmet"}],"abstract":"We consider the integrate-and-fire model of the cardiac pacemaker with delayed pulsatile coupling. Sufficient conditions of synchronization are obtained for identical and non-identical oscillators.","source":"arXiv","year":2011,"language":"en","subjects":["nlin.AO"],"url":"https://arxiv.org/abs/1102.4462","pdf_url":"https://arxiv.org/pdf/1102.4462","is_open_access":true,"published_at":"2011-02-22T11:17:19Z","score":55},{"id":"ss_7e8a90412cb5e8dd38e4c9e36d479f18a92a4ac3","title":"Saturation of Stationary Inversion States in a Three-Level Traveling-Wave Quantum Amplifier with Bistable Resonator Pumping","authors":[{"name":"D. N. Makovetskii"}],"abstract":"The inversion states of a saturated traveling-wave three-level quantum paramagnetic amplifier have been investigated under conditions of bistable resonator pumping. The equations of motion for the vectorial order parameter have been obtained using adiabatic elimination of fast variables. The exact solutions for stationary inversion states have been found from these equations. For high-quality pump resonators, the isolated and the semi-isolated branches of the inversion ratio have been revealed in stationary solutions. The existence of the semi-isolated branches means a possibility of collapse of the inversion state under influence of a saturating signal. Revival of inversion is possible in this case only by the hard excitation of the pump system. This nonlinear phenomenon is of a qualitatively another nature than one described by us in arXiv:0901.0449v1 [nlin.AO], and may be observed at moderate Q-factor of pump resonator.","source":"Semantic Scholar","year":2009,"language":"en","subjects":["Physics"],"doi":"10.1615/TELECOMRADENG.V59.I7-9.100","url":"https://www.semanticscholar.org/paper/7e8a90412cb5e8dd38e4c9e36d479f18a92a4ac3","is_open_access":true,"citations":2,"published_at":"","score":53.06},{"id":"arxiv_0911.2124","title":"Saturation of Stationary Inversion States in a Three-Level Traveling-Wave Quantum Amplifier with Bistable Resonator Pumping","authors":[{"name":"D. N. Makovetskii"}],"abstract":"The inversion states of a saturated traveling-wave three-level quantum paramagnetic amplifier have been investigated under conditions of bistable resonator pumping. The equations of motion for the vectorial order parameter have been obtained using adiabatic elimination of fast variables. The exact solutions for stationary inversion states have been found from these equations. For high-quality pump resonators, the isolated and the semi-isolated branches of the inversion ratio have been revealed in stationary solutions. The existence of the semi-isolated branches means a possibility of collapse of the inversion state under influence of a saturating signal. Revival of inversion is possible in this case only by the hard excitation of the pump system. This nonlinear phenomenon is of a qualitatively another nature than one described by us in arXiv:0901.0449v1 [nlin.AO], and may be observed at moderate Q-factor of pump resonator.","source":"arXiv","year":2009,"language":"en","subjects":["nlin.SI","cond-mat.other","physics.optics"],"url":"https://arxiv.org/abs/0911.2124","pdf_url":"https://arxiv.org/pdf/0911.2124","is_open_access":true,"published_at":"2009-11-11T12:45:51Z","score":53},{"id":"crossref_10.1016/j.tox.2007.06.066","title":"Metabolism of 2-amino-3-methylimidazol [4,5,f]quinoline by precision-cut rat liver slices","authors":[{"name":"Nlin Arya"},{"name":"Costas Ioannides"},{"name":"Nikolai Kuhnert"},{"name":"Jo Kirkpatrick"},{"name":"Derek Stevenson"}],"abstract":"","source":"CrossRef","year":2007,"language":"en","subjects":null,"doi":"10.1016/j.tox.2007.06.066","url":"https://doi.org/10.1016/j.tox.2007.06.066","is_open_access":true,"published_at":"","score":51},{"id":"ss_80fe837124fb086cbacf53c8810c8f353a23dff5","title":"Basic Aspects of Negator Algebra in SOC","authors":[{"name":"R. Zimmermann"}],"abstract":"Recent developments in loop quantum gravity and topological quantum field theory are being mirrored with a view to the emergent structure of self- organized criticality (SOC). Referring back to an earlier paper [nlin.AO/ 0105064], the relationship of SOC to negator algebra is discussed. It is shown that introducing the categorial perspective leads to further holistic conclusions of considerable universality. This present paper shall serve as a preparation of a concrete research project under way designed to illustrate this very universality. Hence, it belongs to a series of recent publications discussing the modern and fruitful interaction between philosophy and the sciences, beyond mere historical aspects and the traditional rephrasing of well-known scientific results.","source":"Semantic Scholar","year":2001,"language":"en","subjects":["Computer Science","Physics"],"url":"https://www.semanticscholar.org/paper/80fe837124fb086cbacf53c8810c8f353a23dff5","is_open_access":true,"citations":5,"published_at":"","score":50.15},{"id":"ss_aa48001bdda81290ca52ead5ddd2a15d48502db2","title":"Decentralization as Organizing Principle of Emergent Urban Structures 1","authors":[{"name":"R. Zimmermann"}],"abstract":"With a view to the ongoing Bologna project (www.arXiv.org, nlin.AO/0109025) general organizing principles of emergent structures in social systems are being discussed with a view to the meaning of decentralization. It is proposed to introduce decentralization as a principle for organizing emergent structures in a generic way utilizing aspects of the insight gained by the Santa Fe school dealing with self-organized criticality. The techniques utilized come from graph theory, category theory, and in particular quantum gravity, which bear a strong potential for a multitude of applications in research fields with a significant interdisciplinary scope. This is especially important for applications in the organization of social systems which usually call for an interaction of logic and hermeneutic.","source":"Semantic Scholar","year":2002,"language":"en","subjects":["Mathematics","Physics"],"url":"https://www.semanticscholar.org/paper/aa48001bdda81290ca52ead5ddd2a15d48502db2","is_open_access":true,"citations":2,"published_at":"","score":50.06},{"id":"crossref_10.2178/jsl/1067620174","title":"A theory for Log-Space and NLIN versus co-NLIN","authors":[{"name":"Chris Pollett"}],"abstract":"AbstractThe use of Nepomnjaščiǐ's Theorem in the proofs of independence results for bounded arithmetic theories is investigated. Using this result and similar ideas, it is shown that at least one ofS1orTLSdoes not prove the Matiyasevich-Robinson-Davis-Putnam Theorem. It is also established thatTLSdoes not prove a statement that roughly means nondeterministic linear time is equal to co-nondeterministic linear time. HereS1is a conservative extension of the well-studied theoryIΔ0andTLSis a theory for LOGSPACE reasoning.","source":"CrossRef","year":2003,"language":"en","subjects":null,"doi":"10.2178/jsl/1067620174","url":"https://doi.org/10.2178/jsl/1067620174","is_open_access":true,"published_at":"","score":50},{"id":"arxiv_nlin/0203012","title":"Decentralization as Organizing Principle of Emergent Urban Structures","authors":[{"name":"Rainer E. Zimmermann"}],"abstract":"With a view to the ongoing Bologna project (www.arXiv.org/pdf/nlin.AO/0109025) general organizing principles of emergent structures in social systems are being discussed with a view to the meaning of decentralization. It is proposed to introduce decentralization as a principle for organizing emergent structures in a generic way utilizing aspects of the insight gained by the Santa Fe school dealing with self-organized criticality. The techniques utilized come from graph theory, category theory, and in particular quantum gravity, which bear a strong potential for a multitude of applications in research fields with a significant interdisciplinary scope. This is especially important for applications in the organization of social systems which usually call for an interaction of logic and hermeneutic.","source":"arXiv","year":2002,"language":"en","subjects":["nlin.AO"],"url":"https://arxiv.org/abs/nlin/0203012","pdf_url":"https://arxiv.org/pdf/nlin/0203012","is_open_access":true,"published_at":"2002-03-07T15:03:34Z","score":50},{"id":"arxiv_nlin/0507067","title":"Quantifying Self-Organization in Cyclic Cellular Automata","authors":[{"name":"Cosma Rohilla Shalizi"},{"name":"Kristina Lisa Shalizi"}],"abstract":"Cyclic cellular automata (CCA) are models of excitable media. Started from random initial conditions, they produce several different kinds of spatial structure, depending on their control parameters. We introduce new tools from information theory that let us calculate the dynamical information content of spatial random processes. This complexity measure allows us to quantitatively determine the rate of self-organization of these cellular automata, and establish the relationship between parameter values and self-organization in CCA. The method is very general and can easily be applied to other cellular automata or even digitized experimental data.","source":"arXiv","year":2005,"language":"en","subjects":["nlin.AO","nlin.CG"],"url":"https://arxiv.org/abs/nlin/0507067","pdf_url":"https://arxiv.org/pdf/nlin/0507067","is_open_access":true,"published_at":"2005-07-29T17:17:22Z","score":50}],"total":153145,"page":1,"page_size":20,"sources":["CrossRef","Semantic Scholar","arXiv"],"query":"nlin.AO"}