{"results":[{"id":"arxiv_2504.02200","title":"A Combinatorial Auction Design for Formulary Positions","authors":[{"name":"Lawrence W. Abrams"}],"abstract":"The purpose of this paper is to apply the economics field of market design to develop a simple algebraic and graphic model of a combinatorial auction for formulary position assignments.","source":"arXiv","year":2025,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2504.02200","pdf_url":"https://arxiv.org/pdf/2504.02200","is_open_access":true,"published_at":"2025-04-03T01:03:27Z","score":69},{"id":"arxiv_2506.11313","title":"Experimenting with Networks","authors":[{"name":"Arun G. Chandrasekhar"},{"name":"Matthew O. Jackson"}],"abstract":"We provide an overview of methods for designing and implementing experiments (field, lab, hybrid, and natural) when there are networks of interactions between subjects.","source":"arXiv","year":2025,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2506.11313","pdf_url":"https://arxiv.org/pdf/2506.11313","is_open_access":true,"published_at":"2025-06-12T21:27:27Z","score":69},{"id":"crossref_10.1186/s12885-023-11792-4","title":"A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial","authors":[{"name":"Divyalakshmi Bhaskaran"},{"name":"Joshua Savage"},{"name":"Amit Patel"},{"name":"Fiona Collinson"},{"name":"Rhys Mant"},{"name":"Florien Boele"},{"name":"Lucy Brazil"},{"name":"Sara Meade"},{"name":"Peter Buckle"},{"name":"Siân Lax"},{"name":"Lucinda Billingham"},{"name":"Susan C. Short"}],"abstract":"Abstract Background Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with tumours showing O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation represent around 40% of newly diagnosed GBM. Relapse/tumour recurrence is inevitable. There is no agreed standard treatment for patients with GBM, therefore, it is aimed at delaying further tumour progression and maintaining health-related quality of life (HRQoL). Limited clinical trial data exist using cannabinoids in combination with temozolomide (TMZ) in this setting, but early phase data demonstrate prolonged overall survival compared to TMZ alone, with few additional side effects. Jazz Pharmaceuticals (previously GW Pharma Ltd.) have developed nabiximols (trade name Sativex®), an oromucosal spray containing a blend of cannabis plant extracts, that we aim to assess for preliminary efficacy in patients with recurrent GBM. Methods ARISTOCRAT is a phase II, multi-centre, double-blind, placebo-controlled, randomised trial to assess cannabinoids in patients with recurrent MGMT methylated GBM who are suitable for treatment with TMZ. Patients who have relapsed ≥ 3 months after completion of initial first-line treatment will be randomised 2:1 to receive either nabiximols or placebo in combination with TMZ. The primary outcome is overall survival time defined as the time in whole days from the date of randomisation to the date of death from any cause. Secondary outcomes include overall survival at 12 months, progression-free survival time, HRQoL (using patient reported outcomes from QLQ-C30, QLQ-BN20 and EQ-5D-5L questionnaires), and adverse events. Discussion Patients with recurrent MGMT promoter methylated GBM represent a relatively good prognosis sub-group of patients with GBM. However, their median survival remains poor and, therefore, more effective treatments are needed. The phase II design of this trial was chosen, rather than phase III, due to the lack of data currently available on cannabinoid efficacy in this setting. A randomised, double-blind, placebo-controlled trial will ensure an unbiased robust evaluation of the treatment and will allow potential expansion of recruitment into a phase III trial should the emerging phase II results warrant this development. Trial registration ISRCTN: 11460478. ClinicalTrials.Gov: NCT05629702.","source":"CrossRef","year":2024,"language":"en","subjects":null,"doi":"10.1186/s12885-023-11792-4","url":"https://doi.org/10.1186/s12885-023-11792-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-023-11792-4.pdf","is_open_access":true,"citations":22,"published_at":"","score":68.66},{"id":"crossref_10.1007/s11764-024-01572-9","title":"Barriers and facilitators to self-management in people living with a lower-grade glioma","authors":[{"name":"Ben Rimmer"},{"name":"Michelle Balla"},{"name":"Lizzie Dutton"},{"name":"Sophie Williams"},{"name":"Vera Araújo-Soares"},{"name":"Pamela Gallagher"},{"name":"Tracy Finch"},{"name":"Joanne Lewis"},{"name":"Richéal Burns"},{"name":"Fiona Menger"},{"name":"Linda Sharp"},{"name":"on behalf of the Ways Ahead study team"}],"abstract":"Abstract Purpose Self-management can have clinical and quality-of-life benefits. However, people with lower-grade gliomas (LGG) may face chronic tumour- and/or treatment-related symptoms and impairments (e.g. cognitive deficits, seizures), which could influence their ability to self-manage. Our study aimed to identify and understand the barriers and facilitators to self-management in people with LGG. Methods We conducted semi-structured interviews with 28 people with LGG across the United Kingdom, who had completed primary treatment. Sixteen participants were male, mean age was 50.4 years, and mean time since diagnosis was 8.7 years. Interviews were audio-recorded and transcribed. Following inductive open coding, we deductively mapped codes to Schulman-Green et al.’s framework of factors influencing self-management, developed in chronic illness. Results Data suggested extensive support for all five framework categories (‘Personal/lifestyle characteristics’, ‘Health status’, ‘Resources’, ‘Environmental characteristics’, ‘Healthcare system’), encompassing all 18 factors influencing self-management. How people with LGG experience many of these factors appears somewhat distinct from other cancers; participants described multiple, often co-occurring, challenges, primarily with knowledge and acceptance of their incurable condition, the impact of seizures and cognitive deficits, transport difficulties, and access to (in)formal support. Several factors were on a continuum, for example, sufficient knowledge was a facilitator, whereas lack thereof, was a barrier to self-management. Conclusions People with LGG described distinctive experiences with wide-ranging factors influencing their ability to self-manage. Implications for cancer survivors These findings will improve awareness of the potential challenges faced by people with LGG around self-management and inform development of self-management interventions for this population.","source":"CrossRef","year":2024,"language":"en","subjects":null,"doi":"10.1007/s11764-024-01572-9","url":"https://doi.org/10.1007/s11764-024-01572-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11764-024-01572-9.pdf","is_open_access":true,"citations":3,"published_at":"","score":68.09},{"id":"arxiv_2402.09125","title":"Database for the meta-analysis of the social cost of carbon (v2026.1)","authors":[{"name":"Richard S. J. Tol"}],"abstract":"A new version of the database for the meta-analysis of estimates of the social cost of carbon is presented. New records were added, and new fields on gender and stochasticity.","source":"arXiv","year":2024,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2402.09125","pdf_url":"https://arxiv.org/pdf/2402.09125","is_open_access":true,"published_at":"2024-02-14T12:23:09Z","score":68},{"id":"crossref_10.1007/s11764-023-01425-x","title":"Identifying and understanding how people living with a lower-grade glioma engage in self-management","authors":[{"name":"Ben Rimmer"},{"name":"Michelle Balla"},{"name":"Lizzie Dutton"},{"name":"Joanne Lewis"},{"name":"Morven C. Brown"},{"name":"Richéal Burns"},{"name":"Pamela Gallagher"},{"name":"Sophie Williams"},{"name":"Vera Araújo-Soares"},{"name":"Tracy Finch"},{"name":"Fiona Menger"},{"name":"Linda Sharp"},{"name":"on behalf of the Ways Ahead study team"}],"abstract":"Abstract Purpose Lower-grade gliomas (LGG) are mostly diagnosed in working-aged adults and rarely cured. LGG patients may face chronic impairments (e.g. fatigue, cognitive deficits). Self-management can improve clinical and psychosocial outcomes, yet how LGG patients self-manage the consequences of their tumour and its treatment is not fully understood. This study, therefore, aimed to identify and understand how LGG patients engage in the self-management of their condition. Methods A diverse group of 28 LGG patients (age range 22–69 years; male n = 16, female n = 12; mean time since diagnosis = 8.7 years) who had completed primary treatment, were recruited from across the United Kingdom. Semi-structured interviews were conducted. Informed by a self-management strategy framework developed in cancer, directed content analysis identified and categorised self-management types and strategies used by patients. Results Overall, 20 self-management strategy types, comprising 123 self-management strategies were reported; each participant detailed extensive engagement in self-management. The most used strategy types were ‘using support’ (n = 28), ‘creating a healthy environment’ (n = 28), ‘meaning making’ (n = 27), and ‘self-monitoring’ (n = 27). The most used strategies were ‘accepting the tumour and its consequences’ (n = 26), ‘receiving support from friends (n = 24) and family’ (n = 24), and ‘reinterpreting negative consequences’ (n = 24). Conclusions This study provides a comprehensive understanding of the strategies used by LGG patients to self-manage their health and wellbeing, with a diverse, and substantial number of self-management strategies reported. Implications for Cancer Survivors The findings will inform the development of a supported self-management intervention for LGG patients, which will be novel for this patient group.","source":"CrossRef","year":2023,"language":"en","subjects":null,"doi":"10.1007/s11764-023-01425-x","url":"https://doi.org/10.1007/s11764-023-01425-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11764-023-01425-x.pdf","is_open_access":true,"citations":7,"published_at":"","score":67.21000000000001},{"id":"crossref_10.1007/s11560-023-00657-3","title":"Komplementvermittelte seltene Glomerulonephritis(GN)-Formen","authors":[{"name":"Bernd Hohenstein"}],"abstract":"","source":"CrossRef","year":2023,"language":"en","subjects":null,"doi":"10.1007/s11560-023-00657-3","url":"https://doi.org/10.1007/s11560-023-00657-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11560-023-00657-3.pdf","is_open_access":true,"citations":1,"published_at":"","score":67.03},{"id":"arxiv_2305.10164","title":"Rational Dialogues","authors":[{"name":"John Geanakoplos"},{"name":"Herakles Polemarchakis"}],"abstract":"Any finite conversation can be rationalized.","source":"arXiv","year":2023,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2305.10164","pdf_url":"https://arxiv.org/pdf/2305.10164","is_open_access":true,"published_at":"2023-05-15T19:43:28Z","score":67},{"id":"arxiv_2310.09588","title":"Über wissenschaftliche Exzellenz und Wettbewerb","authors":[{"name":"Gerald Schweiger"}],"abstract":"The pursuit of excellence seems to be the True North of academia. What is meant by excellence? Can excellence be measured? This article discusses the concept of excellence in the context of research and competition.","source":"arXiv","year":2023,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2310.09588","pdf_url":"https://arxiv.org/pdf/2310.09588","is_open_access":true,"published_at":"2023-10-14T14:10:47Z","score":67},{"id":"crossref_10.3390/cancers14194767","title":"Potassium Ion Channels in Malignant Central Nervous System Cancers","authors":[{"name":"Yasmin Boyle"},{"name":"Terrance G. Johns"},{"name":"Emily V. Fletcher"}],"abstract":"Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. Potassium ion channels have long been implicated in the progression of many cancers due to their integral role in several hallmarks of the disease. Here, we will explore this relationship further, with a focus on malignant CNS cancers, including high-grade glioma (HGG). HGG is the most lethal form of primary brain tumour in adults, with the majority of patient mortality attributed to drug-resistant secondary tumours. Hence, targeting proteins that are integral to cellular plasticity could reduce tumour recurrence, improving survival. This review summarises the role of potassium ion channels in malignant CNS cancers, specifically how they contribute to proliferation, invasion, metastasis, angiogenesis, and plasticity. We will also explore how specific modulation of these proteins may provide a novel way to overcome drug resistance and improve patient outcomes.","source":"CrossRef","year":2022,"language":"en","subjects":null,"doi":"10.3390/cancers14194767","url":"https://doi.org/10.3390/cancers14194767","is_open_access":true,"citations":15,"published_at":"","score":66.45},{"id":"arxiv_2202.00006","title":"Impact of Information and Communication Technology on Individual Well-being","authors":[{"name":"Aneel Bhusal"}],"abstract":"This paper investigates the impact of information and communication technology (ICT) adoption on individual well-being.","source":"arXiv","year":2022,"language":"en","subjects":["econ.GN","stat.AP","stat.ME"],"url":"https://arxiv.org/abs/2202.00006","pdf_url":"https://arxiv.org/pdf/2202.00006","is_open_access":true,"published_at":"2022-01-30T22:16:28Z","score":66},{"id":"arxiv_2202.00007","title":"Impact of Gold Prices on Stock Exchange: An Empirical Case Study of Nepal","authors":[{"name":"Aneel Bhusal"},{"name":"Madhu Sudan Gautam"}],"abstract":"The purpose of this study is to examine the long-run relationship between gold prices and Nepal Stock Exchange (NEPSE).","source":"arXiv","year":2022,"language":"en","subjects":["econ.GN","stat.AP"],"url":"https://arxiv.org/abs/2202.00007","pdf_url":"https://arxiv.org/pdf/2202.00007","is_open_access":true,"published_at":"2022-01-30T22:22:36Z","score":66},{"id":"arxiv_2210.11525","title":"On the Financing of Climate Change Adaptation in Developing Countries","authors":[{"name":"Francis X. Diebold"}],"abstract":"I offer reflections on adaptation to climate change, with emphasis on developing areas.","source":"arXiv","year":2022,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2210.11525","pdf_url":"https://arxiv.org/pdf/2210.11525","is_open_access":true,"published_at":"2022-10-20T18:52:36Z","score":66},{"id":"arxiv_2102.01716","title":"A survey of some recent applications of optimal transport methods to econometrics","authors":[{"name":"Alfred Galichon"}],"abstract":"This paper surveys recent applications of methods from the theory of optimal transport to econometric problems.","source":"arXiv","year":2021,"language":"en","subjects":["econ.GN"],"doi":"10.1111/ectj.12083","url":"https://arxiv.org/abs/2102.01716","pdf_url":"https://arxiv.org/pdf/2102.01716","is_open_access":true,"published_at":"2021-02-02T19:16:59Z","score":65},{"id":"arxiv_2102.02577","title":"The VAR at Risk","authors":[{"name":"Alfred Galichon"}],"abstract":"I show that the structure of the firm is not neutral in respect to regulatory capital budgeted under rules which are based on the Value-at-Risk.","source":"arXiv","year":2021,"language":"en","subjects":["econ.GN"],"doi":"10.1142/S0219024910005875","url":"https://arxiv.org/abs/2102.02577","pdf_url":"https://arxiv.org/pdf/2102.02577","is_open_access":true,"published_at":"2021-02-04T12:30:07Z","score":65},{"id":"arxiv_2106.09498","title":"The Concept, Types and Structure of Corruption","authors":[{"name":"Oleg Antonov"},{"name":"Ekaterina Lineva"}],"abstract":"The article analyzes the essence of the phenomenon of corruption, highlights its main varieties and characteristics. The authors of the study apply historical analysis, emphasizing the long-term nature of corruption and its historical roots. The paper uses legal analysis to characterize the legal interpretation of corruption as an economic crime.","source":"arXiv","year":2021,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2106.09498","pdf_url":"https://arxiv.org/pdf/2106.09498","is_open_access":true,"published_at":"2021-06-17T13:48:09Z","score":65},{"id":"arxiv_2111.09846","title":"The Curious Case of the 2021 Minneapolis Ward 2 City Council Election","authors":[{"name":"David McCune"},{"name":"Lori McCune"}],"abstract":"In this article we explain why the November 2021 election for the Ward 2 city council seat in Minneapolis, MN, may be the mathematically most interesting ranked choice election in US history.","source":"arXiv","year":2021,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2111.09846","pdf_url":"https://arxiv.org/pdf/2111.09846","is_open_access":true,"published_at":"2021-11-18T18:14:16Z","score":65},{"id":"arxiv_2001.02509","title":"Ways to Reduce Cost of Living: A Case Study among Low Income Household in Kubang Pasu, Kedah, Malaysia","authors":[{"name":"Mukaramah Harun"}],"abstract":"This study was conducted to examine and understand the spending behavior of low income households (B40), namely households with income of RM3800 and below. The study focused on the area Kubang Pasu District, Kedah.","source":"arXiv","year":2020,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/2001.02509","pdf_url":"https://arxiv.org/pdf/2001.02509","is_open_access":true,"published_at":"2020-01-07T06:39:23Z","score":64},{"id":"arxiv_1909.08564","title":"Informe-pais Brasil","authors":[{"name":"Juan Gonzalez-Blanco"}],"abstract":"Structural socioeconomic analysis of Brazil. All basic information about this South American country is gathered in a comprehensive outlook that includes the challenges Brazil faces, as well as their causes and posible economic solutions.","source":"arXiv","year":2019,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/1909.08564","pdf_url":"https://arxiv.org/pdf/1909.08564","is_open_access":true,"published_at":"2019-09-18T16:43:45Z","score":63},{"id":"arxiv_1807.09475","title":"CAP and Monetary Policy","authors":[{"name":"Carl Duisberg"}],"abstract":"Despite the importance of CAP-related agricultural market regulation mechanisms within Europe, the agricultural sectors in European countries retain a degree of sensitivity to macroeconomic activity and policies. This reality now raises the question of the effects to be expected from the implementation of the single monetary policy on these agricultural sectors within the Monetary Union.","source":"arXiv","year":2018,"language":"en","subjects":["econ.GN"],"url":"https://arxiv.org/abs/1807.09475","pdf_url":"https://arxiv.org/pdf/1807.09475","is_open_access":true,"published_at":"2018-07-25T08:21:39Z","score":62}],"total":198257,"page":1,"page_size":20,"sources":["arXiv","CrossRef"],"query":"econ.GN"}