{"results":[{"id":"ss_16c341ac119296149b2a0ca7a68d09f78cc422c6","title":"Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline.","authors":[{"name":"S. Lutz"},{"name":"L. Berk"},{"name":"E. Chang"},{"name":"E. Chow"},{"name":"C. Hahn"},{"name":"P. Hoskin"},{"name":"D. Howell"},{"name":"A. Konski"},{"name":"L. Kachnic"},{"name":"S. Lo"},{"name":"A. Sahgal"},{"name":"Larry N. Silverman"},{"name":"C. V. von Gunten"},{"name":"E. Mendel"},{"name":"A. Vassil"},{"name":"D. Bruner"},{"name":"W. Hartsell"}],"abstract":"","source":"Semantic Scholar","year":2011,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.ijrobp.2010.11.026","url":"https://www.semanticscholar.org/paper/16c341ac119296149b2a0ca7a68d09f78cc422c6","is_open_access":true,"citations":790,"published_at":"","score":78.7},{"id":"ss_2d62ed6903dac88dbec6a2694730d22f8833ce0c","title":"Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline.","authors":[{"name":"S. Lutz"},{"name":"T. Balboni"},{"name":"Joshua Jones"},{"name":"S. Lo"},{"name":"J. Petit"},{"name":"S. Rich"},{"name":"R. Wong"},{"name":"C. Hahn"}],"abstract":"","source":"Semantic Scholar","year":2017,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.prro.2016.08.001","url":"https://www.semanticscholar.org/paper/2d62ed6903dac88dbec6a2694730d22f8833ce0c","pdf_url":"http://www.practicalradonc.org/article/S1879850016301229/pdf","is_open_access":true,"citations":424,"published_at":"","score":73.72},{"id":"arxiv_2602.02058","title":"Astro-COLIBRI: An Innovative Platform for Real-Time Multi-Messenger Astrophysics","authors":[{"name":"Bernardo Cornejo Avila"},{"name":"Sofia Bisero"},{"name":"Mickael Costa"},{"name":"Antoine Ciric"},{"name":"Ilja Jaroschewski"},{"name":"Weizmann Kindrébéogo"},{"name":"Fabian Schussler"}],"abstract":"The discovery of transient phenomena, such as supernovae, novae, Fast Radio Bursts (FRBs), Gamma-Ray Bursts (GRBs), and stellar flares, together with the emergence of new cosmic messengers like high-energy neutrinos and Gravitational Waves (GWs), has revolutionized astrophysics in recent years. To fully exploit the scientific potential of multi-messenger and multi-wavelength follow-up observations, as well as serendipitous detections, researchers need a tool capable of rapidly compiling and contextualizing essential information for every new event. We present Astro-COLIBRI, an advanced platform designed to meet this challenge.   Astro-COLIBRI is a comprehensive platform that combines a public RESTful API, real-time databases, a cloud-based alert system, and user-friendly interfaces including a website and mobile app for iOS and Android. It ingests alerts from multiple sources in real time, applies user-defined filters, and situates each event within its multi-messenger and multi-wavelength context. The platform provides clear data visualization, concise summaries of key event properties, and evaluations of observing conditions across a wide network of observatories worldwide. We here detail the architecture of Astro-COLIBRI, from the data pipelines that manage real-time alert ingestion and processing to the design of the RESTful API, which enables seamless integration with other astronomical software and services.","source":"arXiv","year":2026,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"url":"https://arxiv.org/abs/2602.02058","pdf_url":"https://arxiv.org/pdf/2602.02058","is_open_access":true,"published_at":"2026-02-02T12:59:41Z","score":70},{"id":"ss_380b37847a052a237091b16aeb55d46b4e56b8a7","title":"External Beam Radiation Therapy for Palliation of Symptomatic Bone Metastases: An ASTRO Clinical Practice Guideline.","authors":[{"name":"Sara Alcorn"},{"name":"Á. Cortés"},{"name":"Lisa Bradfield"},{"name":"M. Brennan"},{"name":"K. Dennis"},{"name":"D. Diaz"},{"name":"Yee-Cheen Doung"},{"name":"Shekinah N C Elmore"},{"name":"L. Hertan"},{"name":"C. Johnstone"},{"name":"Joshua A. Jones"},{"name":"N. Larrier"},{"name":"Simon S. Lo"},{"name":"Quynh-Nhu Nguyen"},{"name":"Yolanda D Tseng"},{"name":"D. Yerramilli"},{"name":"S. Zaky"},{"name":"Tracy Balboni"}],"abstract":"PURPOSE This guideline provides evidence-based recommendations for palliative external beam radiation therapy (RT) in symptomatic bone metastases. METHODS The American Society for Radiation Oncology (ASTRO) convened a task force to address 5 key questions regarding palliative RT in symptomatic bone metastases. Based on a systemic review by the Agency for Health Research and Quality, recommendations using predefined consensus-building methodology were established; evidence quality and recommendation strength were also assessed. RESULTS For palliative RT for symptomatic bone metastases, RT is recommended for managing pain from bone metastases and spine metastases with or without spinal cord or cauda equina compression. Regarding other modalities with RT, for patients with spine metastases causing spinal cord or cauda equina compression, surgery and postoperative RT are conditionally recommended over RT alone. Furthermore, dexamethasone is recommended for spine metastases with spinal cord or cauda equina compression. Patients with non-spine bone metastases requiring surgery are recommended postoperative RT. Symptomatic bone metastases treated with conventional RT are recommended 800 cGy in 1 fraction (800 cGy/1fx), 2000 cGy/5fx, 2400 cGy/6fx, or 3000 cGy/10fx. Spinal cord or cauda equina compression in patients ineligible for surgery and receiving conventional RT are recommended 800 cGy/1fx, 1600 cGy/2fx, 2000 cGy/5fx, or 3000 cGy/10fx. Symptomatic bone metastases in selected patients with good performance status without surgery or neurological symptoms/signs are conditionally recommended SBRT over conventional palliative RT. Spine bone metastases re-irradiated with conventional RT are recommended 800 cGy/1fx, 2000 cGy/5fx, 2400 cGy/6fx, or 2000 cGy/8fx; non-spine bone metastases re-irradiated with conventional RT are recommended 800 cGy/1fx, 2000 cGy/5fx, or 2400 cGy/6fx. Determination of an optimal RT approach/regimen requires whole person assessment, including prognosis, previous RT dose if applicable, risks to normal tissues, quality of life, cost implications, and patient goals and values. Relatedly, for patient-centered optimization of treatment-related toxicities and quality of life, shared decision-making is recommended. CONCLUSIONS Based on published data, the ASTRO task force's recommendations inform best clinical practices on palliative RT for symptomatic bone metastases.","source":"Semantic Scholar","year":2024,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.prro.2024.04.018","url":"https://www.semanticscholar.org/paper/380b37847a052a237091b16aeb55d46b4e56b8a7","is_open_access":true,"citations":54,"published_at":"","score":69.62},{"id":"ss_a1cbe47d127f71a49debb39a52537fe1119dc861","title":"Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part I: Introduction and Treatment Decision-Making at the Time of Suspected Biochemical Recurrence after Radical Prostatectomy","authors":[{"name":"Todd M. Morgan"},{"name":"S. Boorjian"},{"name":"M. Buyyounouski"},{"name":"B. Chapin"},{"name":"David Y T Chen"},{"name":"Heather H. Cheng"},{"name":"Roger Chou"},{"name":"Heather A Jacene"},{"name":"Sophia C. Kamran"},{"name":"Sennett K. Kim"},{"name":"Erin Kirkby"},{"name":"A. Luckenbaugh"},{"name":"Ben J Nathanson"},{"name":"Y. Nyame"},{"name":"Edwin M Posadas"},{"name":"P. T. Tran"},{"name":"Ronald C. Chen"}],"abstract":"Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part I of a three-part series focusing on treatment decision-making at the time of suspected biochemical recurrence (BCR) after radical prostatectomy (RP). Please refer to Part II for discussion of treatment delivery for non-metastatic BCR after RP and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Advancing work in the area of diagnostic tools (particularly imaging), biomarkers, radiation delivery, and biological manipulation with the evolving armamentarium of therapeutic agents will undoubtedly present new opportunities for patients to experience long-term control of their cancer while minimizing toxicity.","source":"Semantic Scholar","year":2024,"language":"en","subjects":["Medicine"],"doi":"10.1097/JU.0000000000003892","url":"https://www.semanticscholar.org/paper/a1cbe47d127f71a49debb39a52537fe1119dc861","is_open_access":true,"citations":50,"published_at":"","score":69.5},{"id":"ss_32827ded439585838b92b6708a04c2add4c89c54","title":"Radiation Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline.","authors":[{"name":"D. Margalit"},{"name":"C. Anker"},{"name":"M. Aristophanous"},{"name":"M. Awan"},{"name":"Gopal K Bajaj"},{"name":"Lisa Bradfield"},{"name":"Joseph A. Califano"},{"name":"Jimmy J Caudell"},{"name":"Christina H Chapman"},{"name":"A. Garden"},{"name":"P. Harari"},{"name":"Amanda R. Helms"},{"name":"Alexander Lin"},{"name":"E. Maghami"},{"name":"Ranee Mehra"},{"name":"L. Parker"},{"name":"Y. Shnayder"},{"name":"Sharon A. Spencer"},{"name":"P. Swiecicki"},{"name":"Jillian Tsai"},{"name":"David J Sher"}],"abstract":"PURPOSE Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct disease from other head and neck tumors. This guideline provides evidence-based recommendations on the critical decisions in its curative treatment, including both definitive and postoperative radiation therapy (RT) management. METHODS ASTRO convened a task force to address 5 key questions on the use of RT for management of HPV-associated OPSCC. These questions included indications for definitive and postoperative RT and chemoradiation; dose-fractionation regimens and treatment volumes; preferred RT techniques and normal tissue considerations; and posttreatment management decisions. The task force did not address indications for primary surgery versus RT. Recommendations were based on a systematic literature review and created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength. RESULTS Concurrent cisplatin is recommended for patients receiving definitive RT with T3-4 disease and/or 1 node \u003e3 cm, or multiple nodes. For similar patients who are ineligible for cisplatin, concurrent cetuximab, carboplatin/5-fluorouracil, or taxane-based systemic therapy are conditionally recommended. In the postoperative setting, RT with concurrent cisplatin (either schedule) is recommended for positive surgical margins or extranodal extension. Postoperative RT alone is recommended for pT3-4 disease, \u003e2 nodes, or a single node \u003e3 cm. Observation is conditionally recommended for pT1-2 disease and a single node ≤3 cm without other risk factors. For patients treated with definitive RT with concurrent systemic therapy, 7000 cGy in 33 to 35 fractions is recommended, and for patients receiving postoperative RT without positive surgical margins and extranodal extension, 5600 to 6000 cGy is recommended. For all patients receiving RT, intensity modulated RT over 3-dimensional techniques with reduction in dose to critical organs at risk (including salivary and swallowing structures) is recommended. Reassessment with positron emission tomography-computed tomography is recommended approximately 3 months after definitive RT/chemoradiation, and neck dissection is recommended for convincing evidence of residual disease; for equivocal positron emission tomography-computed tomography findings, either neck dissection or repeat imaging is recommended. CONCLUSIONS The role and practice of RT continues to evolve for HPV-associated OPSCC, and these guidelines inform best clinical practice based on the available evidence.","source":"Semantic Scholar","year":2024,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.prro.2024.05.007","url":"https://www.semanticscholar.org/paper/32827ded439585838b92b6708a04c2add4c89c54","pdf_url":"http://www.practicalradonc.org/article/S1879850024001395/pdf","is_open_access":true,"citations":36,"published_at":"","score":69.08},{"id":"crossref_10.21070/ups.8652","title":"E-Comic Astro Kids Explore Milky Way","authors":[{"name":"Febi Talitha Salsabila"},{"name":"Machful Indrakurniawan"}],"abstract":"","source":"CrossRef","year":2025,"language":"en","subjects":null,"doi":"10.21070/ups.8652","url":"https://doi.org/10.21070/ups.8652","is_open_access":true,"published_at":"","score":69},{"id":"arxiv_2507.06616","title":"Astro-COLIBRI: A Comprehensive Platform for Real-Time Multi-Messenger Astrophysics","authors":[{"name":"Fabian Schüssler"},{"name":"B. Cornejo"},{"name":"M. Costa"},{"name":"I. Jaroschewski"},{"name":"W. Kiendrébéogo"}],"abstract":"The detection of transient phenomena such as Gamma-Ray Bursts (GRBs), Fast Radio Bursts (FRBs), stellar flares, novae, and supernovae, alongside novel cosmic messengers like high-energy neutrinos and gravitational waves, has transformed astrophysics in recent years. Maximizing the discovery potential of multi-messenger and multi-wavelength follow-up observations, as well as serendipitous detections, requires a tool that rapidly compiles and contextualizes relevant information for each new event. We present Astro-COLIBRI, an advanced platform designed to meet this challenge.   Astro-COLIBRI integrates a public RESTful API, real-time databases, a cloud-based alert system, and user-friendly clients (a website and mobile apps for iOS and Android). It processes astronomical alerts from multiple streams in real time, filtering them based on user-defined criteria and placing them in their multi-wavelength and multi-messenger context. The platform offers intuitive data visualization, a quick summary of relevant event properties, and an assessment of observing conditions at numerous observatories worldwide.   We here describe its architecture, data resources, and main functionalities. We highlight the automatic collection of photometric data from a variety of large scale optical surveys, a recently added feature that significantly improves the capabilities of the Astro-COLIBRI platform.","source":"arXiv","year":2025,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"url":"https://arxiv.org/abs/2507.06616","pdf_url":"https://arxiv.org/pdf/2507.06616","is_open_access":true,"published_at":"2025-07-09T07:38:12Z","score":69},{"id":"arxiv_2507.10226","title":"Astro-COLIBRI: Empowering Citizen Scientists in Multi-Messenger Astrophysics","authors":[{"name":"Fabian Schüssler"},{"name":"B. Cornejo"},{"name":"M. Costa"},{"name":"I. Jaroschewski"},{"name":"W. Kiendrébéogo"}],"abstract":"In the era of real-time astronomy, citizen scientists play an increasingly important role in the discovery and follow-up of transient astrophysical phenomena. From local astronomical societies to global initiatives, amateur astronomers contribute valuable observational data that complement professional efforts. Astro-COLIBRI facilitates these contributions by providing a user-friendly platform that integrates real-time alerts, data visualization tools, and collaborative features to support astronomers at all levels.   The Astro-COLIBRI Citizen Science Program provides engagement opportunities across multiple scales. At the grassroots level, we collaborate with local astronomy clubs, equipping them with accessible tools for transient event monitoring. National and international networks, such as RAPAS in France, leverage Astro-COLIBRI's real-time capabilities for coordinated observations. On a global scale, we actively participate in high-impact citizen science and capacity building initiatives, including the International Astronomical Union (IAU) Citizen Science Program and the \"Open Universe\" initiative led by the United Nations Office for Outer Space Affairs (UNOOSA). These collaborations enhance the accessibility of real-time astrophysical data and foster inclusive participation in cutting-edge astronomy.   In this contribution, we will present the Astro-COLIBRI Citizen Science Program, highlighting its technical framework, community impact, and case studies of successful amateur contributions. We will showcase how our platform facilitates the rapid exchange of information between professional and amateur astronomers, democratizing access to multi-messenger astrophysics and enabling the global community to contribute meaningfully to time-domain discoveries.","source":"arXiv","year":2025,"language":"en","subjects":["astro-ph.IM","astro-ph.HE","physics.pop-ph","physics.soc-ph","physics.space-ph"],"url":"https://arxiv.org/abs/2507.10226","pdf_url":"https://arxiv.org/pdf/2507.10226","is_open_access":true,"published_at":"2025-07-14T12:45:28Z","score":69},{"id":"ss_8b929c69b4d8a4362e45790056bd26074b59767b","title":"Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part III: Salvage Therapy After Radiotherapy or Focal Therapy, Pelvic Nodal Recurrence and Oligometastasis, and Future Directions","authors":[{"name":"Todd M. Morgan"},{"name":"S. Boorjian"},{"name":"M. Buyyounouski"},{"name":"B. Chapin"},{"name":"David Y T Chen"},{"name":"Heather H. Cheng"},{"name":"Roger Chou"},{"name":"Heather A Jacene"},{"name":"Sophia C. Kamran"},{"name":"Sennett K. Kim"},{"name":"Erin Kirkby"},{"name":"A. Luckenbaugh"},{"name":"Ben J Nathanson"},{"name":"Y. Nyame"},{"name":"Edwin M Posadas"},{"name":"P. T. Tran"},{"name":"Ronald C. Chen"}],"abstract":"Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part III of a three-part series focusing on evaluation and management of suspected non-metastatic recurrence after radiotherapy (RT) and focal therapy, evaluation and management of regional recurrence, management for molecular imaging metastatic recurrence, and future directions. Please refer to Part I for discussion of treatment decision-making and Part II for discussion of treatment delivery for non-metastatic biochemical recurrence (BCR) after radical prostatectomy (RP). Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Guideline Panel developed evidence- and consensus-based guideline statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Continuous and deliberate efforts for multidisciplinary care in prostate cancer will be required to optimize and improve the oncologic and functional outcomes of patients treated with salvage therapies in the future.","source":"Semantic Scholar","year":2024,"language":"en","subjects":["Medicine"],"doi":"10.1097/JU.0000000000003890","url":"https://www.semanticscholar.org/paper/8b929c69b4d8a4362e45790056bd26074b59767b","is_open_access":true,"citations":30,"published_at":"","score":68.9},{"id":"ss_e643441c1f39e0e5c24c3bf832ad935ea7afabaa","title":"Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part II: Treatment Delivery for Non-metastatic Biochemical Recurrence After Primary Radical Prostatectomy","authors":[{"name":"Todd M. Morgan"},{"name":"S. Boorjian"},{"name":"M. Buyyounouski"},{"name":"B. Chapin"},{"name":"David Y T Chen"},{"name":"Heather H. Cheng"},{"name":"Roger Chou"},{"name":"Heather A Jacene"},{"name":"Sophia C. Kamran"},{"name":"Sennett K. Kim"},{"name":"Erin Kirkby"},{"name":"A. Luckenbaugh"},{"name":"Ben J Nathanson"},{"name":"Y. Nyame"},{"name":"Edwin M Posadas"},{"name":"P. T. Tran"},{"name":"Ronald C. Chen"}],"abstract":"Purpose: The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part II of a three-part series focusing on treatment delivery for non-metastatic biochemical recurrence (BCR) after primary radical prostatectomy (RP). Please refer to Part I for discussion of treatment decision-making and Part III for discussion of evaluation and management of recurrence after radiotherapy (RT) and focal therapy, regional recurrence, and oligometastasis. Materials and Methods: The systematic review that informs this Guideline was based on searches in Ovid MEDLINE (1946 to July 21, 2022), Cochrane Central Register of Controlled Trials (through August 2022), and Cochrane Database of Systematic Reviews (through August 2022). Update searches were conducted on July 26, 2023. Searches were supplemented by reviewing electronic database reference lists of relevant articles. Results: In a collaborative effort between AUA, ASTRO, and SUO, the Salvage Therapy for Prostate Cancer Panel developed evidence- and consensus-based guideline statements to provide guidance for the care of patients who experience BCR after initial definitive local therapy for clinically localized disease. Conclusions: Optimizing and personalizing the approach to salvage therapy remains an ongoing area of work in the field of genitourinary oncology and represents an area of research and clinical care that requires well-coordinated, multi-disciplinary efforts.","source":"Semantic Scholar","year":2024,"language":"en","subjects":["Medicine"],"doi":"10.1097/JU.0000000000003891","url":"https://www.semanticscholar.org/paper/e643441c1f39e0e5c24c3bf832ad935ea7afabaa","is_open_access":true,"citations":27,"published_at":"","score":68.81},{"id":"arxiv_2406.01817","title":"Managing the Growing Complexity of Multi-Messenger Transient Events with Astro-COLIBRI","authors":[{"name":"Fabian Schüssler"},{"name":"A. Kaan Alkan"},{"name":"M. de Bony de Lavergne"},{"name":"J. Mourier"}],"abstract":"Observations of transient phenomena, such as GRBs, FRBs, novae/supernovae explosions, coupled with the detection of cosmic messengers like high-energy neutrinos and gravitational waves, have transformed astrophysics. Maximizing the discovery potential necessitates tools for swiftly acquiring an overview of the most relevant information for each new detection. Introducing Astro-COLIBRI, a comprehensive platform designed to meet this challenge. Astro-COLIBRI features a public API, real-time databases and alert systems, a discussion forum, and a website and iOS/Android apps as user clients. In real time, it evaluates incoming astronomical observation messages from all available alert streams, filters them based on user-defined criteria, and contextualizes them in the multi-wavelength (MWL) and multi-messenger (MM) context. User clients offer a graphical representation, providing a succinct summary for quick identification of interesting phenomena and assessing observing conditions globally.","source":"arXiv","year":2024,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"url":"https://arxiv.org/abs/2406.01817","pdf_url":"https://arxiv.org/pdf/2406.01817","is_open_access":true,"published_at":"2024-06-03T22:14:23Z","score":68},{"id":"ss_24552c4470da27b902e523e9dae1f93cdf4ffcb4","title":"Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma: An ASTRO Clinical Practice Guideline.","authors":[{"name":"L. Halasz"},{"name":"A. Attia"},{"name":"Lisa Bradfield"},{"name":"D. Brat"},{"name":"J. Kirkpatrick"},{"name":"N. Laack"},{"name":"N. Lalani"},{"name":"Emily S. Lebow"},{"name":"Arthur K Liu"},{"name":"H. Niemeier"},{"name":"J. Palmer"},{"name":"K. Peters"},{"name":"J. Sheehan"},{"name":"R. Thomas"},{"name":"S. Vora"},{"name":"D. Wahl"},{"name":"S. Weiss"},{"name":"D. N. Yeboa"},{"name":"J. Zhong"},{"name":"H. Shih"}],"abstract":"PURPOSE This guideline provides evidence-based recommendations for adults with isocitrate dehydrogenase (IDH)-mutant grade 2 and grade 3 diffuse glioma, as classified in the 2021 World Health Organization (WHO) Classification of Tumours. It includes indications for radiation therapy (RT), advanced RT techniques, and clinical management of adverse effects. METHODS The American Society for Radiation Oncology convened a multidisciplinary task force to address 4 key questions focused on the RT management of patients with IDH-mutant grade 2 and grade 3 diffuse glioma. Recommendations were based on a systematic literature review and created using a predefined consensus-building methodology and system for grading evidence quality and recommendation strength. RESULTS A strong recommendation for close surveillance alone was made for patients with oligodendroglioma, IDH-mutant, 1p/19q codeleted, WHO grade 2 after gross total resection without high-risk features. For oligodendroglioma, WHO grade 2 with any high-risk features, adjuvant RT was conditionally recommended. However, adjuvant RT was strongly recommended for oligodendroglioma, WHO grade 3. A conditional recommendation for close surveillance alone was made for astrocytoma, IDH-mutant, WHO grade 2 after gross total resection without high-risk features. Adjuvant RT was conditionally recommended for astrocytoma, WHO grade 2, with any high-risk features and strongly recommended for astrocytoma, WHO grade 3. Dose recommendations varied based on histology and grade. Given known adverse long-term effects of RT, consideration for advanced techniques such as intensity modulated radiation therapy/volumetric modulated arc therapy or proton therapy were given as strong and conditional recommendations, respectively. Finally, based on expert opinion, the guideline recommends assessment, surveillance, and management for toxicity management. CONCLUSIONS Based on published data, the American Society for Radiation Oncology task force has proposed recommendations to inform the management of adults with IDH-mutant grade 2 and grade 3 diffuse glioma as defined by WHO 2021 classification, based on the highest quality published data, and best translated by our task force of subject matter experts.","source":"Semantic Scholar","year":2022,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.prro.2022.05.004","url":"https://www.semanticscholar.org/paper/24552c4470da27b902e523e9dae1f93cdf4ffcb4","is_open_access":true,"citations":52,"published_at":"","score":67.56},{"id":"arxiv_2309.14725","title":"Citizen Science Time Domain Astronomy with Astro-COLIBRI","authors":[{"name":"Fabian Schüssler"},{"name":"M. de Bony de Lavergne"},{"name":"A. Kaan Alkan"},{"name":"J. Mourier"},{"name":"P. Reichherzer"}],"abstract":"Astro-COLIBRI is an innovative tool designed for professional astronomers to facilitate the study of transient astronomical events. Transient events - such as supernovae, gamma-ray bursts and stellar mergers - are fleeting cataclysmic phenomena that can offer profound insights into the most violent processes in the universe. Revealing their secrets requires rapid and precise observations: Astro-COLIBRI alerts its users of new transient discoveries from observatories all over the world in real-time. The platform also provides observers the details they need to make follow-up observations.   Some of the transient phenomena available through Astro-COLIBRI are accessible by amateur astronomers and citizen scientists. A subset of the features dedicated to this growing group of users are highlighted here. They include the possibility of receiving only alerts on very bright events, the possibility of defining custom observer locations, as well as the calculation of optimized observation plans for searches for optical counterparts to gravitational wave events.","source":"arXiv","year":2023,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"url":"https://arxiv.org/abs/2309.14725","pdf_url":"https://arxiv.org/pdf/2309.14725","is_open_access":true,"published_at":"2023-09-26T07:35:58Z","score":67},{"id":"arxiv_2308.07044","title":"Astro-COLIBRI: An Advanced Platform for Real-Time Multi-Messenger Astrophysics","authors":[{"name":"Fabian Schüssler"},{"name":"Mathieu de Bony de Lavergne"},{"name":"Atilla Kaan Alkan"},{"name":"Jayson Mourier"},{"name":"Patrick Reichherzer"}],"abstract":"Observations of transient phenomena like Gamma-Ray Bursts (GRBs), Fast Radio Bursts (FRBs), stellar flares and explosions (novae and supernovae), combined with the detection of novel cosmic messengers like high-energy neutrinos and gravitational waves has revolutionized astrophysics over the last years. The discovery potential of both ulti-messenger and multi-wavelength follow-up observations as well as serendipitous observations could be maximized with a novel tool which allows for quickly acquiring an overview over relevant information associated with each new detection. Here we present Astro-COLIBRI, a novel and comprehensive platform for this challenge.   Astro-COLIBRI's architecture comprises a public RESTful API, real-time databases, a cloud-based alert system and a website as well as apps for iOS and Android as clients for users. Astro-COLIBRI evaluates incoming messages of astronomical observations from all available alert streams in real time, filters them by user specified criteria and puts them into their MWL and MM context. The clients provide a graphical representation with an easy to grasp summary of the relevant data to allow for the fast identification of interesting phenomena, provides an assessment of observing conditions at a large selection of observatories around the world, and much more.   Here the key features of Astro-COLIBRI are presented. We outline the architecture, summarize the used data resources, and provide examples for applications and use cases. Focussing on the high-energy domain, we'll discuss the use of the platform in searches for high-energy gamma-ray counterparts to high-energy neutrinos, gamma-ray bursts and gravitational waves.","source":"arXiv","year":2023,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"doi":"10.22323/1.444.1469","url":"https://arxiv.org/abs/2308.07044","pdf_url":"https://arxiv.org/pdf/2308.07044","is_open_access":true,"published_at":"2023-08-14T10:08:55Z","score":67},{"id":"arxiv_2212.00805","title":"Astro-COLIBRI 2 -- an advanced platform for real-time multi-messenger discoveries","authors":[{"name":"P. Reichherzer"},{"name":"F. Schüssler"},{"name":"V. Lefranc"},{"name":"J. Becker Tjus"},{"name":"J. Mourier"},{"name":"A. K. Alkan"}],"abstract":"The study of flaring astrophysical events in the multi-messenger approach requires instantaneous follow-up observations to better understand the nature of these events through complementary observational data. We present Astro-COLIBRI as a platform that integrates specific tools in the real-time multi-messenger ecosystem. The Astro-COLIBRI platform bundles and evaluates alerts about transients from various channels. It further automates the coordination of follow-up observations by providing and linking detailed information through its comprehensible graphical user interface. We present the functionalities with documented examples of Astro-COLIBRI usage through the community since its public release in August 2021. We highlight the use cases of Astro-COLIBRI for planning follow-up observations by professional and amateur astronomers, as well as checking predictions from theoretical models.","source":"arXiv","year":2022,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"doi":"10.3390/galaxies11010022","url":"https://arxiv.org/abs/2212.00805","pdf_url":"https://arxiv.org/pdf/2212.00805","is_open_access":true,"published_at":"2022-12-01T17:12:24Z","score":66},{"id":"arxiv_2107.05335","title":"Astro-COLIBRI: a new platform for real-time multi-messenger astrophysics","authors":[{"name":"Fabian Schüssler"},{"name":"Atilla Kaan Alkan"},{"name":"Valentin Lefranc"},{"name":"Patrick Reichherzer"}],"abstract":"Flares of known astronomical sources and new transient phenomena occur on different timescales, from sub-seconds to several days or weeks. The discovery potential of both serendipitous observations and multi-messenger and multi-wavelength follow-up observations could be maximized with a tool which allows for quickly acquiring an overview over both persistent sources as well as transient events in the relevant phase space. We here present COincidence LIBrary for Real-time Inquiry (Astro-COLIBRI), a novel and comprehensive tool for this task.   Astro-COLIBRI's architecture comprises a RESTful API, a real-time database, a cloud-based alert system and a website (https://astro-colibri.com) as well as apps for iOS and Android as clients for users. The structure of Astro-COLIBRI is optimized for performance and reliability and exploits concepts such as multi-index database queries, a global content delivery network (CDN), and direct data streams from the database to the clients. Astro-COLIBRI evaluates incoming VOEvent messages of astronomical observations in real time, filters them by user-specified criteria and puts them into their MWL and MM context. The clients provide a graphical representation with an easy to grasp summary of the relevant data to allow for the fast identification of interesting phenomena and provides an assessment of observing conditions at a large selection of observatories around the world.   We here summarize the key features of Astro-COLIBRI, the architecture and used data resources. We specifically provide examples for applications and use cases. Focussing on the high-energy domain, we showcase how Astro-COLIBRI facilitates the search for high-energy gamma-ray counterparts to high-energy neutrinos and scheduling of follow-up observations of a large variety of transient phenomena like gamma-ray bursts, gravitational waves, TDEs, FRBs, and others.","source":"arXiv","year":2021,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"doi":"10.22323/1.395.0935","url":"https://arxiv.org/abs/2107.05335","pdf_url":"https://arxiv.org/pdf/2107.05335","is_open_access":true,"published_at":"2021-07-12T11:49:28Z","score":65},{"id":"arxiv_2109.01672","title":"Astro-COLIBRI -- The COincidence LIBrary for Real-time Inquiry for multimessenger astrophysics","authors":[{"name":"P. Reichherzer"},{"name":"F. Schüssler"},{"name":"V. Lefranc"},{"name":"A. Yusafzai"},{"name":"A. K. Alkan"},{"name":"H. Ashkar"},{"name":"J. Becker Tjus"}],"abstract":"Astro-COLIBRI is a novel tool that evaluates alerts of transient observations in real time, filters them by user-specified criteria, and puts them into their multiwavelength and multimessenger context. Through fast generation of an overview of persistent sources as well as transient events in the relevant phase space, Astro-COLIBRI contributes to an enhanced discovery potential of both serendipitous and follow-up observations of the transient sky. The software's architecture comprises a Representational State Transfer Application Programming Interface, both a static and a real-time database, a cloud-based alert system, as well as a website and apps for iOS and Android as clients for users. The latter provide a graphical representation with a summary of the relevant data to allow for the fast identification of interesting phenomena along with an assessment of observing conditions at a large selection of observatories around the world.","source":"arXiv","year":2021,"language":"en","subjects":["astro-ph.IM","astro-ph.HE"],"doi":"10.3847/1538-4365/ac1517","url":"https://arxiv.org/abs/2109.01672","pdf_url":"https://arxiv.org/pdf/2109.01672","is_open_access":true,"published_at":"2021-09-03T18:00:01Z","score":65},{"id":"ss_a7d1ec91c524af1adfdb652c431a67834f159a54","title":"Hitomi (ASTRO-H) X-ray Astronomy Satellite","authors":[{"name":"Tadayuki Takahashi"},{"name":"M. Kokubun"},{"name":"K. Mitsuda"},{"name":"R. Kelley"},{"name":"T. Ohashi"},{"name":"F. Aharonian"},{"name":"H. Akamatsu"},{"name":"F. Akimoto"},{"name":"S. Allen"},{"name":"N. Anabuki"},{"name":"L. Angelini"},{"name":"K. Arnaud"},{"name":"M. Asai"},{"name":"M. Audard"},{"name":"H. Awaki"},{"name":"M. Axelsson"},{"name":"P. Azzarello"},{"name":"C. Baluta"},{"name":"A. Bamba"},{"name":"N. Bando"},{"name":"M. Bautz"},{"name":"T. Bialas"},{"name":"R. Blandford"},{"name":"K. Boyce"},{"name":"L. Brenneman"},{"name":"G. Brown"},{"name":"E. Bulbul"},{"name":"E. Cackett"},{"name":"E. Canavan"},{"name":"M. Chernyakova"},{"name":"M. Chiao"},{"name":"P. Coppi"},{"name":"E. Costantini"},{"name":"Steve O’ Dell"},{"name":"M. Dipirro"},{"name":"C. Done"},{"name":"T. Dotani"},{"name":"J. Doty"},{"name":"K. Ebisawa"},{"name":"M. Eckart"},{"name":"T. Enoto"},{"name":"Y. Ezoe"},{"name":"Andrew C. Fabian"},{"name":"C. Ferrigno"},{"name":"A. Foster"},{"name":"R. Fujimoto"},{"name":"Y. Fukazawa"},{"name":"S. Funk"},{"name":"A. Furuzawa"},{"name":"M. Galeazzi"},{"name":"L. Gallo"},{"name":"P. Gandhi"},{"name":"K. Gilmore"},{"name":"M. Giustini"},{"name":"A. Goldwurm"},{"name":"L. Gu"},{"name":"M. Guainazzi"},{"name":"D. Haas"},{"name":"Y. Haba"},{"name":"K. Hagino"},{"name":"K. Hamaguchi"},{"name":"I. Harrus"},{"name":"I. Hatsukade"},{"name":"T. Hayashi"},{"name":"K. Hayashi"},{"name":"K. Hayashida"},{"name":"J. D. den Herder"},{"name":"J. Hiraga"},{"name":"K. Hirose"},{"name":"A. Hornschemeier"},{"name":"A. Hoshino"},{"name":"J. Hughes"},{"name":"Y. Ichinohe"},{"name":"R. Iizuka"},{"name":"H. Inoue"},{"name":"Y. Inoue"},{"name":"K. Ishibashi"},{"name":"M. Ishida"},{"name":"K. Ishikawa"},{"name":"K. Ishimura"},{"name":"Y. Ishisaki"},{"name":"M. Itoh"},{"name":"M. Iwai"},{"name":"N. Iwata"},{"name":"N. Iyomoto"},{"name":"C. Jewell"},{"name":"J. Kaastra"},{"name":"T. Kallman"},{"name":"T. Kamae"},{"name":"E. Kara"},{"name":"J. Kataoka"},{"name":"S. Katsuda"},{"name":"J. Katsuta"},{"name":"Madoka Kawaharada"},{"name":"N. Kawai"},{"name":"T. Kawano"},{"name":"S. Kawasaki"},{"name":"D. Khangulyan"},{"name":"C. Kilbourne"},{"name":"M. Kimball"},{"name":"A. King"},{"name":"T. Kitaguchi"},{"name":"S. Kitamoto"},{"name":"T. Kitayama"},{"name":"T. Kohmura"},{"name":"S. Konami"},{"name":"T. Kosaka"},{"name":"A. Koujelev"},{"name":"K. Koyama"},{"name":"S. Koyama"},{"name":"P. Kretschmar"},{"name":"H. Krimm"},{"name":"Aya Kubota"},{"name":"H. Kunieda"},{"name":"P. Laurent"},{"name":"Shiu-Hang Lee"},{"name":"M. Leutenegger"},{"name":"O. Limousin"},{"name":"M. Loewenstein"},{"name":"K. Long"},{"name":"D. Lumb"},{"name":"G. Madejski"},{"name":"Y. Maeda"},{"name":"D. Maier"},{"name":"K. Makishima"},{"name":"M. Markevitch"},{"name":"Candace Masters"},{"name":"H. Matsumoto"},{"name":"Kyoko Matsushita"},{"name":"D. McCammon"},{"name":"D. Mcguinness"},{"name":"B. McNamara"},{"name":"M. Mehdipour"},{"name":"J. Miko"},{"name":"E. Miller"},{"name":"Jonathan M. Miller"},{"name":"S. Mineshige"},{"name":"K. Minesugi"},{"name":"I. Mitsuishi"},{"name":"T. Miyazawa"},{"name":"T. Mizuno"},{"name":"H. Mori"},{"name":"K. Mori"},{"name":"Franco Moroso"},{"name":"H. Moseley"},{"name":"Theodore Muench"},{"name":"K. Mukai"},{"name":"H. Murakami"},{"name":"T. Murakami"},{"name":"R. Mushotzky"},{"name":"H. Nagano"},{"name":"Ryo Nagino"},{"name":"T. Nakagawa"},{"name":"H. Nakajima"},{"name":"T. Nakamori"},{"name":"T. Nakano"},{"name":"Shinya Nakashima"},{"name":"K. Nakazawa"},{"name":"Y. Namba"},{"name":"C. Natsukari"},{"name":"Y. Nishioka"},{"name":"K. Nobukawa"},{"name":"M. Nobukawa"},{"name":"H. Noda"},{"name":"M. Nomachi"},{"name":"H. Odaka"},{"name":"H. Ogawa"},{"name":"M. Ogawa"},{"name":"K. Ogi"},{"name":"M. Ohno"},{"name":"M. Ohta"},{"name":"T. Okajima"},{"name":"A. Okamoto"},{"name":"T. Okazaki"},{"name":"N. Ota"},{"name":"M. Ozaki"},{"name":"F. Paerels"},{"name":"S. Paltani"},{"name":"A. Parmar"},{"name":"R. Petre"},{"name":"C. Pinto"},{"name":"J. de Plaa"},{"name":"M. Pohl"},{"name":"J. Pontius"},{"name":"F. Porter"},{"name":"K. Pottschmidt"},{"name":"B. Ramsey"},{"name":"C. Reynolds"},{"name":"H. Russell"},{"name":"S. Safi-Harb"},{"name":"S. Saito"},{"name":"K. Sakai"},{"name":"S. Sakai"},{"name":"H. Sameshima"},{"name":"T. Sasaki"},{"name":"G. Sato"},{"name":"Kosuke Sato"},{"name":"R. Sato"},{"name":"Yoichi Sato"},{"name":"M. Sawada"},{"name":"N. Schartel"},{"name":"P. Serlemitsos"},{"name":"H. Seta"},{"name":"Y. Shibano"},{"name":"M. Shida"},{"name":"M. Shidatsu"},{"name":"T. Shimada"},{"name":"K. Shinozaki"},{"name":"P. Shirron"},{"name":"A. Simionescu"},{"name":"C. Simmons"},{"name":"Randall K. Smith"},{"name":"G. Sneiderman"},{"name":"Y. Soong"},{"name":"Ł. Stawarz"},{"name":"Y. Sugawara"},{"name":"S. Sugita"},{"name":"H. Sugita"},{"name":"A. Szymkowiak"},{"name":"H. Tajima"},{"name":"H. Takahashi"},{"name":"S. Takeda"},{"name":"Y. Takei"},{"name":"T. Tamagawa"},{"name":"T. Tamura"},{"name":"K. Tamura"},{"name":"Takaaki Tanaka"},{"name":"Yasuo Tanaka"},{"name":"Yasuyuki T. Tanaka"},{"name":"M. Tashiro"},{"name":"Y. Tawara"},{"name":"Y. Terada"},{"name":"Yuichi Terashima"},{"name":"F. Tombesi"},{"name":"H. Tomida"},{"name":"Y. Tsuboi"},{"name":"M. Tsujimoto"},{"name":"H. Tsunemi"},{"name":"T. Tsuru"},{"name":"H. Uchida"},{"name":"H. Uchiyama"},{"name":"Yasunobu Uchiyama"},{"name":"S. Ueda"},{"name":"Y. Ueda"},{"name":"S. Ueno"},{"name":"S. Uno"},{"name":"C. M. Urry"},{"name":"E. Ursino"},{"name":"C. D. de Vries"},{"name":"A. Wada"},{"name":"S. Watanabe"},{"name":"Tomomi Watanabe"},{"name":"N. Werner"},{"name":"D. Wik"},{"name":"D. Wilkins"},{"name":"B. Williams"},{"name":"S. Yamada"},{"name":"Takahiro Yamada"},{"name":"H. Yamaguchi"},{"name":"K. Yamaoka"},{"name":"N. Yamasaki"},{"name":"M. Yamauchi"},{"name":"S. Yamauchi"},{"name":"T. Yaqoob"},{"name":"Y. Yatsu"},{"name":"D. Yonetoku"},{"name":"A. Yoshida"},{"name":"T. Yuasa"},{"name":"I. Zhuravleva"},{"name":"A. Zoghbi"}],"abstract":"Abstract. The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E  \u003e  2  keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month.","source":"Semantic Scholar","year":2018,"language":"en","subjects":["Engineering"],"doi":"10.1117/1.JATIS.4.2.021402","url":"https://www.semanticscholar.org/paper/a7d1ec91c524af1adfdb652c431a67834f159a54","pdf_url":"https://www.spiedigitallibrary.org/journals/Journal-of-Astronomical-Telescopes-Instruments-and-Systems/volume-4/issue-2/021402/Hitomi-ASTRO-H-X-ray-Astronomy-Satellite/10.1117/1.JATIS.4.2.021402.pdf","is_open_access":true,"citations":100,"published_at":"","score":65},{"id":"ss_5d87d5364c645b7fc95ab25156c622387c3107f6","title":"The Astro-H high resolution soft x-ray spectrometer","authors":[{"name":"R. Kelley"},{"name":"H. Akamatsu"},{"name":"P. Azzarello"},{"name":"T. Bialas"},{"name":"K. Boyce"},{"name":"G. Brown"},{"name":"E. Canavan"},{"name":"M. Chiao"},{"name":"E. Costantini"},{"name":"M. Dipirro"},{"name":"M. Eckart"},{"name":"Y. Ezoe"},{"name":"R. Fujimoto"},{"name":"D. Haas"},{"name":"J. D. den Herder"},{"name":"A. Hoshino"},{"name":"K. Ishikawa"},{"name":"Y. Ishisaki"},{"name":"N. Iyomoto"},{"name":"C. Kilbourne"},{"name":"M. Kimball"},{"name":"S. Kitamoto"},{"name":"S. Konami"},{"name":"S. Koyama"},{"name":"M. Leutenegger"},{"name":"D. McCammon"},{"name":"K. Mitsuda"},{"name":"I. Mitsuishi"},{"name":"H. Moseley"},{"name":"H. Murakami"},{"name":"M. Murakami"},{"name":"H. Noda"},{"name":"M. Ogawa"},{"name":"T. Ohashi"},{"name":"A. Okamoto"},{"name":"N. Ota"},{"name":"S. Paltani"},{"name":"F. Porter"},{"name":"K. Sakai"},{"name":"Kosuke Sato"},{"name":"Yohichi Sato"},{"name":"M. Sawada"},{"name":"H. Seta"},{"name":"K. Shinozaki"},{"name":"P. Shirron"},{"name":"G. Sneiderman"},{"name":"H. Sugita"},{"name":"A. Szymkowiak"},{"name":"Y. Takei"},{"name":"T. Tamagawa"},{"name":"M. Tashiro"},{"name":"Y. Terada"},{"name":"M. Tsujimoto"},{"name":"C. D. de Vries"},{"name":"S. Yamada"},{"name":"N. Yamasaki"},{"name":"Y. Yatsu"}],"abstract":"","source":"Semantic Scholar","year":2016,"language":"en","subjects":["Physics","Engineering"],"doi":"10.1117/12.2232509","url":"https://www.semanticscholar.org/paper/5d87d5364c645b7fc95ab25156c622387c3107f6","is_open_access":true,"citations":115,"published_at":"","score":63.45}],"total":1163083,"page":1,"page_size":20,"sources":["CrossRef","arXiv","Semantic Scholar"],"query":"astro-ph.IM"}