{"results":[{"id":"crossref_10.1016/b978-0-323-96014-4.00002-1","title":"Other Blood Group Systems, Collections, and Antigens","authors":[{"name":"Lynsi Rahorst"},{"name":"Michelle Lodermeier"}],"abstract":"","source":"CrossRef","year":2025,"language":"en","subjects":null,"doi":"10.1016/b978-0-323-96014-4.00002-1","url":"https://doi.org/10.1016/b978-0-323-96014-4.00002-1","is_open_access":true,"citations":1,"published_at":"","score":69.03},{"id":"doaj_Continuous+Glucose+Monitoring+During+Recreational+Diving+in+Type+1+Diabetes%3A+Navigating+Clinical+and+Technical+Uncertainties","title":"Continuous Glucose Monitoring During Recreational Diving in Type 1 Diabetes: Navigating Clinical and Technical Uncertainties","authors":[{"name":"Popovic DS"},{"name":"Koufakis T"},{"name":"Patoulias D"},{"name":"Stoian AP"},{"name":"Papanas N"}],"abstract":"Djordje S Popovic,1 Theocharis Koufakis,2 Dimitrios Patoulias,2 Anca Pantea Stoian,3 Nikolaos Papanas4 1Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Vojvodina, Medical Faculty, University of Novi Sad, Novi Sad, Serbia; 2Second Propaedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Department of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 4Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, GreeceCorrespondence: Djordje S Popovic, Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Vojvodina, Medical Faculty, University of Novi Sad, Hajduk Veljkova 1, Novi Sad, 21000, Serbia, Tel +38163551606, Email pitstop021@gmail.com; djordje.popovic@mf.uns.ac.rsAbstract: Recreational diving with self-contained underwater breathing devices is gaining popularity worldwide as a sport and leisure activity. People living with type 1 diabetes mellitus (PLT1D) are no exception, although historically diabetes mellitus, especially insulin-treated, has been described as an absolute contra-indication for diving. However, based on observational data collected by the Divers Alert Network, the presence of background diabetes mellitus became only a relative contraindication for those without significant co-morbidities or long-term complications. Regarding diving activities among PLT1D, the primary concern is the risk of hypoglycaemia, especially in those with impaired awareness. Furthermore, symptoms consistent with hypoglycaemia could be confused with those originating from other factors related to diving. Although avoidance of hypoglycaemia is imperative among PLT1D practicing diving, the risk of severe hyperglycaemia should also be minimised. Continuous glucose monitoring (CGM) nowadays represents the standard of care for PLT1D, but its accuracy during diving activities is still a matter of debate. This commentary aims to summarize the existing data on accuracy, durability, and underwater performance of different CGM devices among PLT1D who engage in diving, and to call for additional research in the field. Based on available results, the application of real-time CGM still requires extreme caution since none of the existing systems has so far met the standards for accurate use in underwater conditions. Further improvements of contemporary CGM devices, validated through large-scale trials, are necessary before their widespread implementation among PLT1D practicing diving. Such advances should further enhance safety during this popular activity.Keywords: continuous glucose monitoring, diving, type 1 diabetes mellitus","source":"DOAJ","year":2025,"language":"","subjects":["Specialties of internal medicine"],"url":"https://www.dovepress.com/continuous-glucose-monitoring-during-recreational-diving-in-type-1-dia-peer-reviewed-fulltext-article-DMSO","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.1177/26334895251389461","title":"Cascading Training Model to Promote Screening, Brief Intervention, and Referral to Treatment Across South Africa: Rollout in an HIV Service Organization","authors":[{"name":"Kira DiClemente-Bosco"},{"name":"Caroline Kuo"},{"name":"Goodman Sibeko"},{"name":"Shaheema Allie"},{"name":"Timothy Souza"},{"name":"Tim Janssen"},{"name":"Warren Cornelius"},{"name":"Ayanda Mkhize"},{"name":"Andrew Scheibe"},{"name":"Anje Pretorius"},{"name":"Tricia Sterling"},{"name":"Sara J. Becker"}],"abstract":"Background In South Africa, rates of HIV and alcohol use are among the highest globally, with a detrimental synergistic relationship. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based, cost-effective approach to identifying people at risk of alcohol-related problems to deliver early intervention. We developed and deployed a cascading train-the-trainer model to promote SBIRT implementation in a large nongovernmental organization offering HIV services across South Africa. Method Between 2021 and 2022, we completed preparatory activities including designing scalable training resources prior to rolling out the train-the-trainer model across two South African provinces. We conducted a comprehensive assessment of outcomes at the trainer- (knowledge, fidelity), provider- (attitudes, confidence, perceived implementation potential, adoption), and client-encounter (reach) levels over approximately one year. Results We trained 12 novice trainers who then trained 206 providers to implement SBIRT. Trainer SBIRT knowledge increased pre- to posttraining, and fidelity of training delivery was high (99.0% of elements covered across sessions). Provider attitudes, confidence, and perceived implementation potential increased over time, and 64% of providers adopted SBIRT. Reach of the model varied by component, with 41,793 clients screened by trained providers. Of those screening positive for risky alcohol use, 86% received brief intervention (BI) and 53% received referral to treatment (RT). Additionally, 15,353 clients who did not screen as having risky alcohol use received BI and 1,122 received RT. Conclusion Results indicated that the cascading training model was delivered with high fidelity, associated with improvements in all provider outcomes, and reached high numbers of clients for the screening component of the model. Rates of BI and RT delivery were moderate to high, though data suggested over-application of these elements with some clients, highlighting the tension between reach and fidelity. Lessons learned will inform future scale-out of this model in HIV service settings in low- and middle-income countries.","source":"DOAJ","year":2025,"language":"","subjects":["Mental healing","Psychiatry"],"doi":"10.1177/26334895251389461","url":"https://doi.org/10.1177/26334895251389461","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.1016/j.jaim.2024.100889","title":"Rapid improvement of oculomotor nerve function with ayurvedic treatment in traumatic diplopia - A case report","authors":[{"name":"K. Shanti"},{"name":"G. Gopinathan"}],"abstract":"Diplopia or double vision has many aetiologies and often presents to the ophthalmologist. The causes of diplopia may be ocular or neurogenic in origin. Any trauma to the eyes in the form of blow-out fractures causes diplopia by damaging the third nerve. The management by the practitioners of contemporary science depends upon the extent of the nerve or muscle injury. Entrapment of muscles requires surgical intervention, whereas others are managed conservatively. The recovery rate is the least for diplopia of traumatic origin.A 50-year-old male who sought Ayurvedic treatment for diplopia in the last three months was diagnosed with partial third nerve palsy after a fracture of the left orbit. He underwent Ayurvedic therapy in the form of internal medicines such as Danadanayanadi kashaya, Ksheerabala 101, Vaishwanara churna, and external treatments such as Pratimarsha Nasya, Siro abhyanga, and Tarpana.At the end of 2 months of Ayurvedic treatment, the patient completely recovered from diplopia.Ayurvedic treatment effectively resolved diplopia in a short time. Patients can benefit from the same if treated promptly in the early stage itself. However, more extensive studies with larger samples will yield more data to prove the potential of Ayurveda in such cases.","source":"DOAJ","year":2024,"language":"","subjects":["Miscellaneous systems and treatments"],"doi":"10.1016/j.jaim.2024.100889","url":"http://www.sciencedirect.com/science/article/pii/S0975947624000044","is_open_access":true,"published_at":"","score":68},{"id":"doaj_10.20473/brpkm.v4i2.58069","title":"Hubungan Grit dan Persepsi Dukungan Supervisor dengan Komitmen Karier pada Karyawan Milenial","authors":[{"name":"Hanna Tania Dwi  Crisanti"},{"name":"Rosatyani Puspita Adiati"}],"abstract":"Perubahan komitmen karyawan saat ini mengarah pada karier mereka daripada organisasi tempat mereka bekerja. Komitmen karier adalah sikap individu terhadap pekerjaan yang meliputi tujuan karier pribadi. Tujuan penelitian ini untuk mengetahui hubungan grit dan persepsi dukungan supervisor dengan komitmen karier karyawan. Partisipan penelitian ini sebanyak 87 partisipan merupakan karyawan/i berusia 24-35 tahun dan sedang bekerja penuh waktu di suatu perusahaan/organisasi. Penelitian ini menggunakan 3 skala, yakni skala Grit yang disusun oleh Duckworth, skala persepsi dukungan supervisor oleh Burns, dan skala komitmen karier oleh Carson dan Bedeian. Analisis data menggunakan bantuan software Jamovi 2.3.28. Hasil penelitian memperoleh terdapat hubungan grit dan persepsi dukungan supervisor dengan komitmen karier pada karyawan milenial. Dengan demikian, organisasi perlu mempertimbangkan pendekatan yang memfokuskan pada pengembangan personal grit karyawan serta memperkuat kualitas hubungan antara supervisor dan karyawan untuk memastikan komitmen jangka panjang karyawan terhadap karier mereka dan kesuksesan organisasi.","source":"DOAJ","year":2024,"language":"","subjects":["Psychology","Mental healing"],"doi":"10.20473/brpkm.v4i2.58069","url":"https://e-journal.unair.ac.id/BRPKM/article/view/58069","is_open_access":true,"published_at":"","score":68},{"id":"doaj_10.1186/s12906-023-03838-8","title":"Prevalence, predictors and pregnancy outcomes of unprescribed and herbal medicine use in Ibadan, Nigeria","authors":[{"name":"Ikeola Adeoye"},{"name":"Victoria Etuk"}],"abstract":"Abstract Background Unprescribed and herbal medicines use among pregnant women is a public health concern in low and middle-income countries because of the potential teratogenic effects, insufficient safety and weak drug regulatory systems. Unprescribed and herbal medicines are common among pregnant women in Nigeria, and only a few researchers have documented the prevalence and the risk factors. However, evidence on the associated pregnancy outcomes is still lacking. We assessed the prevalence, predictors and pregnancy outcomes of unprescribed and herbal medicines use among pregnant women in Ibadan, Nigeria. Methods This study was a component of the Ibadan Pregnancy Cohort Study, a prospective cohort study, among pregnant women in Ibadan, Nigeria, who were enrolled at ≤ 20 weeks gestation at their first antenatal visit and followed up till delivery. In all, 571 women participated in the maternal drug use assessment during the third trimester using a pretested interviewer-administered questionnaire. The primary outcomes were unprescribed and herbal medicines use and pregnancy outcomes, secondary outcomes, were abstracted from medical records. The predictors assessed included sociodemographic, obstetric, antenatal care utilization, and lifestyle characteristics. Bi-variate logistic and Poisson regression analyses were used to evaluate the predictors and relative risk for the pregnancy outcomes of unprescribed and herbal medicines at 5% significance. Results The prevalence of unprescribed and herbal medicine use was 31.9% and 21.7%, respectively. On bivariate analysis, the significant predictors of unprescribed medicine (which were protective) were tertiary education, increasing income, adequate antenatal care (≥ 4 visits), and at least two doses of sulfadoxine-pyrimethamine. However, high parity and having an antenatal admission increased the risk. However, after adjusting for confounders, the significant factors associated with unprescribed medicines were; tertiary education (AOR) = 0.23; 95% CI: (0.06 – 0.95); p-value: 0.043] and obtaining at least two doses of sulfadoxine-pyrimethamine [AOR = 0.33; 95% CI: (0.29 – 3.60); p-value: 0.048]. For herbal medicines, the predictors were similar to unprescribed drugs. However, after adjusting for confounders, none was significant for herbal medicines. Unprescribed and herbal medicines were not significantly associated with pregnancy outcomes. Conclusions Unprescribed and herbal medicines use were common among pregnant women in Ibadan, Nigeria, particularly among women with low economic status and those with poor utilization of antenatal care services. These significant predictors can be targeted for public health intervention. Specifically, health education that discourages the use of unprescribed and herbal medications to pregnant women during antenatal care.","source":"DOAJ","year":2023,"language":"","subjects":["Other systems of medicine"],"doi":"10.1186/s12906-023-03838-8","url":"https://doi.org/10.1186/s12906-023-03838-8","is_open_access":true,"published_at":"","score":67},{"id":"doaj_10.1016/j.jaim.2022.100603","title":"8th International Congress of Society for Ethnopharmacology India – “Ethnopharmacology and Medicinal Plants – Approach towards product development”","authors":[{"name":"Sathiyanarayanan Lohidasan"},{"name":"K.R. Mahadik"},{"name":"Pulok K. Mukherjee"},{"name":"Subhash C. Mandal"},{"name":"Amit Kar"}],"abstract":"","source":"DOAJ","year":2023,"language":"","subjects":["Miscellaneous systems and treatments"],"doi":"10.1016/j.jaim.2022.100603","url":"http://www.sciencedirect.com/science/article/pii/S0975947622000626","is_open_access":true,"published_at":"","score":67},{"id":"doaj_10.54909/sp.v7i1.128242","title":"ELABORAÇÃO DE ROTEIRO PARA O DESENVOLVIMENTO DE  INFOGRÁFICO ANIMADO EDUCACIONAL SOBRE MÉTODO CANGURU","authors":[{"name":"Melissa Martins  Souto"},{"name":"Micael Doria de  Andrade"},{"name":"Rosangela Andrade Aukar de  Camargo"}],"abstract":"\nNascimento pré-termo é aquele que ocorre com menos de 37 semanas de idade gestacional. Considera-se com baixo peso o bebê que nasce com menos de 2.500 gramas. Ambos são fatores de risco para o desenvolvimento de afecções perinatais. Embora existam estigmas envolvidos no nascimento de um bebê com essas condições – tais como falta de informações dos familiares –, o Método Canguru, como parte da educação em saúde, pode contribuir para mitigar mortalidades nesses recém-nascidos. Tais estratégias educativas podem ser realizadas pela utilização de tecnologias educacionais, como infográficos animados norteados por roteiros. O presente estudo objetivou a concepção e a execução da elaboração do conteúdo (roteiro) para o desenvolvimento de infográfico animado sobre o Método Canguru. Trata-se de um estudo metodológico. No roteiro, após análise documental e de similares (vídeos semelhantes na rede), delimitou-se o tema Método Canguru, com descrição de suas etapas e vantagens, focado em famílias de recém-nascidos pré-termo e/ou com baixo peso, hospitalizados em Unidades de Terapia Intensiva. Articulou-se a criação da identidade dos personagens com a locução e auxílios visuais, possibilitando explorar diferentes formas de aprendizagens e melhorar a capacidade de recepção das informações. Totalizaram-se 22 cenas que abordam a apresentação das personagens e dos conceitos, a descrição de etapas, as atribuições do enfermeiro neste contexto, as vantagens da realização da posição canguru e a importância do acompanhamento do bebê e da família pela Atenção Primária à Saúde. Apesar da complexidade que envolve a elaboração de recursos educacionais, foi possível construir um roteiro para o desenvolvimento do infográfico animado sobre o Método Canguru com informações que buscam atender às necessidades do público-alvo. Espera-se que este estudo possa fomentar e ampliar a prática da utilização de recursos educacionais para o cuidado qualificado do recém-nascido pré-termo e promover a reflexão de profissionais da saúde-gestores-comunidade sobre o tema. \n","source":"DOAJ","year":2023,"language":"","subjects":["Miscellaneous systems and treatments","Public aspects of medicine"],"doi":"10.54909/sp.v7i1.128242","url":"https://seer.ufrgs.br/index.php/saberesplurais/article/view/128242","is_open_access":true,"published_at":"","score":67},{"id":"doaj_10.51335/organoid.2022.2.e30","title":"Generation of proximal tubule spheroids for nephrotoxicity assessment","authors":[{"name":"Dae Hun Kim"},{"name":"Jung Hwa Lim"},{"name":"Cho-Rok Jung"},{"name":"Hyun Mi Kang"}],"abstract":"Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in preclinical studies were withdrawn from clinical trials due to nephrotoxicity, which means the current renal cell lines used in preclinical trials have limitations for the accurate detection of nephrotoxicity. Methods and Results Here, we established proximal tubule cell lines from immortalized mixed primary renal cells and generated functional proximal tubule cell spheroids, which expressed all apical basolateral transporters and showed epithelial polarity. Moreover, they showed a more sensitive drug response than hPTECs, which have been commonly used as in vitro kidney models. Conclusion Taken together, the proximal tubule cells described in this study provide a more stable, reproducible, and accurate in vitro kidney model for predicting nephrotoxicity, which could help early compound development.","source":"DOAJ","year":2022,"language":"","subjects":["Biotechnology","Miscellaneous systems and treatments"],"doi":"10.51335/organoid.2022.2.e30","url":"http://j-organoid.org/upload/pdf/organoid-2022-2-e30.pdf","pdf_url":"http://j-organoid.org/upload/pdf/organoid-2022-2-e30.pdf","is_open_access":true,"published_at":"","score":66},{"id":"doaj_10.1016/j.phyplu.2022.100351","title":"Efficacy of integrative medicine using Yinhua-based herbal granules on herpangina: A Bayesian network meta-analysis of randomized controlled trials","authors":[{"name":"Yongcheng Sheng"},{"name":"Yuhui Zhang"},{"name":"Qin Wang"},{"name":"Qi Hong"},{"name":"Deying Kang"}],"abstract":"Background: Different Traditional Chinese Medicine (TCM) in the format of granules, such as Kanggan Granules (KangGs), Kouyanqing Granules (KouGs), Lianhua Qingwen Granules (LQGs), Qingkailing Granules (QGs) and Xiao'er Qingjie Granules (XQJGs), collectively named Yinhua-based herbal granules (YH-HGs) have been widely used in the management of pediatric outpatients with herpangina. Few head-to-head randomized controlled trials (RCTs) have compared the efficacy of these agents. This network meta-analysis (NMA) was conducted to indirectly compare the efficacy of YH-HGs. Methods: This systematic review and fixed-effect NMA was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) extension statement for NMA. RCTs assessing the efficacy and safety of YH-HGs in children that were also receiving ribavirin as the conventional therapy were searched from eight databases and two trial registers up to Jan 13, 2022. The primary outcome was total effectiveness rate (TER). The secondary outcomes were total adverse events (TAEs) and the time to symptom improvement of fever, vesicles, pain and salivation. Relative risk (RR) and weighted mean difference with 95% confidence intervals (CIs) were estimated by direct pairwise meta-analysis (MA) and NMA. Results: A total of 10 RCTs, enrolling 1 017 pediatric patients, were included. YH-HGs were better than no medication (NM) in TER (RR = 1.22, 95%CIs, 1.16 – 1.28) by direct pairwise MA, in which KangGs (RR = 1.24, 95%CIs, 1.05 – 1.47), KouGs (RR = 1.17, 95%CIs, 1.08 – 1.27), LQGs (RR = 1.24, 95%CIs, 1.14 – 1.35), QGs (RR = 1.33, 95%CIs, 1.11 – 1.58) and XQJGs (RR = 1.18, 95%CIs, 1.00 – 1.40) were also more efficient than NM. As for secondary outcomes, YH-HGs was associated with a 103% increased risk of TAEs compared to NM, but no significant differences were found. YH-HGs has a more positive symptom improvement effect than NM in fever, vesicles, pain and salivation. The ranking results showed that QGs (79.2%) had the highest probability ranking first in TER and KangGs (63.6%) ranked as the second, followed by LQGs (52.4%), XQJGs (50.3%), KouGs (49.7%), and NM (4.9%) at last. Conclusions: Our findings support the better efficacy of YH-HGs than NM as regards TER. QGs, KangGs, LQGs, XQJGs, KouGs remain superior to NM and their clinical choice should depend on the patient's conditions to improve symptoms better for the different effects. Given the limitations of NMA, head-to-head RCTs with high-quality are needed.","source":"DOAJ","year":2022,"language":"","subjects":["Other systems of medicine"],"doi":"10.1016/j.phyplu.2022.100351","url":"http://www.sciencedirect.com/science/article/pii/S2667031322001312","is_open_access":true,"published_at":"","score":66},{"id":"doaj_10.52692/1857-0011.2022.3-74.40","title":"HIPOTIROIDISMUL INDUS DE PREPRATELE ANTITUBERCULOASE","authors":[{"name":"Nicolae BACINSCHI"},{"name":"Lorina VUDU"},{"name":"Stela BACINSCHI-GHEORGHITA"},{"name":"Aurelia BACINSCHI"}],"abstract":"Туберкулез — инфекционное заболевание, поражающее практически все органы, в том числе и щитовидную железу. Одновременно изменение функции щитовидной железы может повысить восприимчивость к инфекции Mycobacterium tuberculosis. Лечение туберкулеза, особенно препаратами второго ряда, может обуславливать раз- витие гипотиреоза. Установлено, что рифампицин, этионамид, протионамид и парааминосалициловая кислота являются одними из наиболее распространенных противотуберкулезных препаратов, ответственных за развитие гипотиреоза. Эти препараты могут вызывать дисфункцию щитовидной железы путем увеличения метаболизма и клиренса тиреоидных гормонов за счет индукции ферментов цитохрома Р-450, нарушения регуляции поглощения йода и синтеза тиреоидных гормонов, изменения действия гормонов на уровне рецепторов и передачи внутрикле- точного сигнала. Лечение этими препаратами требует контроля функции щитовидной железы во время лечения, особенно в первые 3 месяцa, а также в пост-лечебный период. Развитие клинического и/или субклинического гипотиреоза потребует применения адекватных доз левотироксина на фоне противотуберкулезного лечения.","source":"DOAJ","year":2022,"language":"","subjects":["Medicine (General)","Internal medicine","Other systems of medicine","Public aspects of medicine"],"doi":"10.52692/1857-0011.2022.3-74.40","url":"https://bulmed.md/bulmed/article/view/3498","is_open_access":true,"published_at":"","score":66},{"id":"doaj_10.55225/hppa.445","title":"Relationships between sacral, lumbar and thoracic spine position and trunk mobility in the sagittal plane in young adults","authors":[{"name":"Katarzyna Wódka"},{"name":"Alicja Michalczyk"},{"name":"Agnieszka Jankowicz-Szymańska"}],"abstract":"Aim of the study: The aim of the study was to assess the relationship between the position of the sacrum, lumbar and thoracic spine and the mobility of the trunk in the sagittal plane in young women and men.\nMaterial and methods: 64 students (33 women and 31 men) were studied. The mean age in the study group was 22.94 ± 1.51 years. The following tests were performed on each subject once: measurement of height and weight, assessment of spinal alignment and mobility in the sagittal plane using Zebris Pointer.\nResults: The results obtained were analyzed using appropriate statistical tools. Statistically significant correlations were obtained: in the alignment of the sacrum in relation to the lumbar spine (strong correlation), in the alignment of the lumbar spine in relation to the thoracic spine and, in the male group only, between the alignment of the thoracic spine and mobility in the direction of flexion in the thoracic segment (moderate correlation).\nConclusions: In women, horizontal sacral alignment coexisting with deepened lordosis was most frequently observed. In addition, women were more likely to have a deepened thoracic kyphosis, less range of motion in the direction of thoracic flexion and extension, and greater mobility in the direction of lumbar flexion and extension than men. In men, the vertical alignment of the sacrum was accompanied by a shallowing of the physiological lordosis. In addition, in this group, a decrease in lordosis influenced an increase in movement to flexion in the thoracic spine. When planning a physiotherapy exercise program for a person in whom abnormalities in the alignment of the lumbopelvic complex have been noted, an individual exercise program should be selected. The study should take into account not only the evaluation of the alignment of the lumbosacral spine, but also the mobility of the segments above and below the examined area taking into account intergender differences.","source":"DOAJ","year":2022,"language":"","subjects":["Medicine (General)","Other systems of medicine","Sports medicine"],"doi":"10.55225/hppa.445","url":"https://journals.anstar.edu.pl/index.php/hppa/article/view/445","is_open_access":true,"published_at":"","score":66},{"id":"doaj_10.4103/jacr.jacr_1_21","title":"Add on effect of Somavalkala kashaya siddha basti in the management of diabetes mellitus: A case report","authors":[{"name":"Nakul Vishwanathji Khode"},{"name":"Maya V. Gokhale"},{"name":"Rashmi Prakash Gurao"}],"abstract":"Diabetes mellitus is a major health problem for the world in the 21st century. The side effects of medicines and persistent complaints make diabetic patients seek alternative therapy. Basti (~therapeutic enema) acclaimed as Ardha chikitsa, is an important Shodhana (~detoxification) procedure in Panchakarma. In general, Basti is contraindicated in Prameha, but many special types of Basti are described in the literature that can be used in distinct cases. This study aims to explore the prospects of Basti chikitsa in the treatment of Prameha. A 56-year-old male suffering from diabetes taking metformin 500 mg tablet twice daily for five years presented with the complaints of polyuria, burning sensation in both upper and lower limbs, weakness and cramps aggravating gradually. HbA1C level (11.6) revealed an uncontrolled blood sugar levels. He was treated with Somavalkala kashaya siddha basti regimen for three months. The patient had significant relief in symptoms such as Prabhuta mutrata, Pipasa, Karapada daha, Karapada supti, Avil mutrata, Klaibya, and Daurbalya after complete course of therapy. The HbA1C level of patient which was 11.5 at the time of registration which lowered to the 6.9, i.e. nearly normal range. Fasting blood sugar and postprandial blood sugar levels were 121 mg/dl and 232 mg/dl, respectively, at the time of registration which reduced after Basti regimen. Thus, Somvalkala kashaya siddha basti appears to be useful in the treatment of diabetes mellitus.","source":"DOAJ","year":2021,"language":"","subjects":["Other systems of medicine"],"doi":"10.4103/jacr.jacr_1_21","url":"https://journals.lww.com/10.4103/jacr.jacr_1_21","is_open_access":true,"published_at":"","score":65},{"id":"doaj_10.1016/j.imu.2020.100452","title":"Bone fracture detection through the two-stage system of Crack-Sensitive Convolutional Neural Network","authors":[{"name":"Yangling Ma"},{"name":"Yixin Luo"}],"abstract":"Automated fracture detection is an essential part in a computer-aided tele-medicine system. Fractures often occur in human's arbitrary bone due to accidental injuries such as slipping. In fact, many hospitals lack experienced surgeons to diagnose fractures. Therefore, computer-aided diagnosis (CAD) reduces the burden on doctors and identifies fracture. We present a new classification network, Crack-Sensitive Convolutional Neural Network (CrackNet), which is sensitive to fracture lines. In this paper, we propose a new two-stage system to detect fracture. Firstly, we use Faster Region with Convolutional Neutral Network (Faster R-CNN) to detect 20 different types of bone regions in X-ray images, and then we recognize whether each bone region is fractured by using CrackNet. Total of 1052 images are used to test our system, of which 526 are fractured images and the rest are non-fractured images. We assess the performance of our proposed system with X-ray images from Haikou People's Hospital, achieving 90.11% accuracy and 90.14% F-measure. And our system is better than other two-stage systems.","source":"DOAJ","year":2021,"language":"","subjects":["Computer applications to medicine. Medical informatics"],"doi":"10.1016/j.imu.2020.100452","url":"http://www.sciencedirect.com/science/article/pii/S235291482030602X","is_open_access":true,"published_at":"","score":65},{"id":"doaj_10.20473/brpkm.v1i1.26783","title":"Pengaruh Efikasi Diri dan Penyesuaian Diri terhadap Stres Akademik pada Mahasiswa Masa Pandemi COVID-19","authors":[{"name":"Ifan Maulana"},{"name":"Ilham Nur Alfian"}],"abstract":"Penelitian ini bertujuan untuk mengetahui pengaruh efikasi diri dan penyesuaian diri terhadap stres akademik pada mahasiswa masa pandemi. Perubahan saat pendemi tersebut menyebabkan mahasiswa mengalami stres akademik dan peneliti ingin mengetahui ada tidaknya pengaruh antara efikasi diri dan penyesuaian diri terhadap stress akademik. Stres akademik yang dikembangkan dari Sarafino and Smith dan faktor yang mempengaruhi stres akademik adalah salah satunya efikasi diri yang disusun oleh Bandura dan penyesuian diri menggunakan teori Baker. Partisipan dalam penelitian ini adalah mahasiswa yang sedang menjalani perkuliahan secara daring/online. Metode penelitian menggunakan tipe penelitian kuantitatif dengan alat pengumpulan data menggunakan survei melalui Google Form. Dalam menganalisis data menggunakan SPSS 25 for windows. Hasil analisis menunjukkan regresi menyebutkan bahwa terdapat 18,1% pengaruh secara bersamaan antara efikasi diri dan penyesuaian diri terhadap stres akademik. Sedangkan pengaruh antara efikasi diri terhadap stress akademik sebesar 68% dan penyesuaian diri terhadap stress akademik sebesar 10,8%.","source":"DOAJ","year":2021,"language":"","subjects":["Psychology","Mental healing"],"doi":"10.20473/brpkm.v1i1.26783","url":"https://e-journal.unair.ac.id/BRPKM/article/view/26783","is_open_access":true,"published_at":"","score":65},{"id":"doaj_10.3390/idr12030022","title":"Spontaneous Pathologic Splenic Rupture in a Patient with \u003ci\u003ePlasmodium falciparum\u003c/i\u003e Infection, First Case Reported in Israel","authors":[{"name":"Yves Weinberg"},{"name":"Arie Feldman"},{"name":"Daniel J. Jakobson"},{"name":"Joseph Mishal"}],"abstract":"Travelers exposed to malaria may develop severe disease and complications. A less well-known complication is spontaneous pathologic splenic rupture, which is still under-reported and has never been reported in Israel. In this paper, we report a 23 years old healthy young man presenting in the emergency department, two weeks after coming back from Sierra Leone, with intermittent fever, mild tachycardia and mild left upper quadrant abdominal pain. The patient was diagnosed with \u003ci\u003ePlasmodium falciparum\u003c/i\u003e infection and developed rapidly after hospital admission spleen rupture. He was managed conservatively at first but ultimately underwent splenectomy after being hemodynamically unstable. In the recovery period, the patient developed acute respiratory distress syndrome and was reintubated. A high level of suspicion is recommended in every malaria patient presenting with left upper quadrant abdominal pain, even if minimal. Ultrasonography availability in the internal medicine department may be a critical diagnostic tool, especially in non-endemic areas.","source":"DOAJ","year":2020,"language":"","subjects":["Other systems of medicine"],"doi":"10.3390/idr12030022","url":"https://www.mdpi.com/2036-7449/12/3/22","is_open_access":true,"published_at":"","score":64},{"id":"doaj_10.1016/j.imr.2020.100611","title":"The root of Scutellaria baicalensis overcomes resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in H1975 cells","authors":[{"name":"Hyun-Ji Park"},{"name":"Shin-Hyung Park"}],"abstract":"","source":"DOAJ","year":2020,"language":"","subjects":["Miscellaneous systems and treatments"],"doi":"10.1016/j.imr.2020.100611","url":"http://www.sciencedirect.com/science/article/pii/S2213422020302432","is_open_access":true,"published_at":"","score":64},{"id":"crossref_10.1016/b978-0-12-813726-0.00030-1","title":"Other Blood Group Systems, Collections, and Series","authors":[{"name":"Debra Jo Bailey"},{"name":"Connie M. Westhoff"}],"abstract":"","source":"CrossRef","year":2019,"language":"en","subjects":null,"doi":"10.1016/b978-0-12-813726-0.00030-1","url":"https://doi.org/10.1016/b978-0-12-813726-0.00030-1","is_open_access":true,"citations":3,"published_at":"","score":63.09},{"id":"doaj_10.1108/JHR-01-2019-0013","title":"Cutting-edge technology and nocturnal headaches in adolescent smart phone users in Chiang Mai, Thailand: A time series study","authors":[{"name":"Wanna Chongchitpaisan"},{"name":"Phongtape Wiwatanadate"},{"name":"Surat Tanprawate"},{"name":"Assawin Narkpongphun"},{"name":"Nipapon Siripon"}],"abstract":"Purpose - Nocturnal headaches among adolescents were reported to be increased with the development of modern technology. The purpose of this paper is to investigate the smartphone electromagnetic radiation related to nocturnal headaches among high school students. Design/methodology/approach - The time series study of all 12,969 records from 145 high school students Chiang Mai Province was selected from the population in the first phase by setting criteria. The samples completed a headache diary utilizing a smartphone application. The smartphone output power (SOP) was measured and recorded by the smartphone application and transmitted by e-mail to a researcher. The smartphone use, sleep quality, anxiety and depression also were assessed. Data were analyzed using Generalized Estimating Equation adjusting for demographic data, smartphone use, and sleep quality and otherwise. Findings - The resulted showed the prevalence of repeated headaches to be 13.4 percent, nocturnal headache only 5.3 percent and the strongest effect of day time SOP at a 1.80–1.99×10−5 mW range on nocturnal headaches (ORadj5.18; 95% CI: 3.44–7.81). Meanwhile, Lag_6 of daily SOP exposure produced a nocturnal headache effect in a reverse dose-response manner. Furthermore, the nocturnal headache also had the strongest association with age, internet use and device brand (ORadj2.33; 95% CI: 1.08–5.05, ORadj2.14; 95% CI: 1.07–4.2 and ORadj1.68; 95% CI: 1.1–2.4). Originality/value - The electromagnetic radiation from a smartphone is the environmental variables influences on headache. The results suggested that there should be limited times for smartphone use and older age to start using a smartphone to prevent headache attacks at night.","source":"DOAJ","year":2019,"language":"","subjects":["Other systems of medicine","Public aspects of medicine"],"doi":"10.1108/JHR-01-2019-0013","url":"https://www.emerald.com/insight/content/doi/10.1108/JHR-01-2019-0013/full/pdf?title=cutting-edge-technology-and-nocturnal-headaches-in-adolescent-smart-phone-users-in-chiang-mai-thailand","pdf_url":"https://www.emerald.com/insight/content/doi/10.1108/JHR-01-2019-0013/full/pdf?title=cutting-edge-technology-and-nocturnal-headaches-in-adolescent-smart-phone-users-in-chiang-mai-thailand","is_open_access":true,"published_at":"","score":63},{"id":"doaj_10.1186/s12906-017-2010-y","title":"Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves","authors":[{"name":"Md. Mahedi Hasan"},{"name":"Amir Hossain"},{"name":"Abdullah Shamim"},{"name":"Md. Mustafizur Rahman"}],"abstract":"Abstract Background The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different experimental models. Methods Quantitative and qualitative analysis were done by TLC (thin layer chromatography) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay. Analgesic, antihyperglycemic and antidiarrheal activities were evaluated using acetic acid induced writhing in mice, oral glucose tolerance test and castor oil induced diarrhea, respectively. Neuropharmacological activity was investigated in mice using both Open Field and Hole Board methods. Results TLC analysis indicated the presence of antioxidant compounds in the extract we used. The extract showed IC50 value was 31.62 μg/mL whereas the standard ascorbic acid showed 12.02 μg/mL. In acetic acid induced writhing assay, the extract showed 46.07% and 58.43% writhing inhibition at the doses of 250 mg/kg and 500 mg/kg body weight, respectively whereas standard diclofenac-Na (25 mg/kg) showed 86.52% writhing inhibition. The plant extract showed significant (p \u003c 0.05) antihyperglycemic activity on mice as compared to control groups. In neuropharmacological activity assay the experimental animal showed a noticeable decrease in locomotion by showing a decrease in number of square crossed and head dipping at both doses (250 mg/kg \u0026 500 mg/kg). In antidiarrheal activity test, the plant extract at the doses of 250 mg/kg and 500 mg/kg showed percent inhibition of defecation 57.89 and 77.19 respectively, whereas standard loperamide (3 mg/kg) showed percent inhibition of defecation 88.59. Conclusion The results demonstrated that the extract has potential antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activity.","source":"DOAJ","year":2017,"language":"","subjects":["Other systems of medicine"],"doi":"10.1186/s12906-017-2010-y","url":"http://link.springer.com/article/10.1186/s12906-017-2010-y","is_open_access":true,"published_at":"","score":61}],"total":9014162,"page":1,"page_size":20,"sources":["DOAJ","CrossRef"],"query":"Other systems of medicine"}