{"results":[{"id":"ss_5efae2551eb22bdcb7e06cf4499d72e0248a4a4f","title":"Role of ROS and Nutritional Antioxidants in Human Diseases","authors":[{"name":"Zewen Liu"},{"name":"Zhangpin Ren"},{"name":"Jun Zhang"},{"name":"Chia-Chen Chuang"},{"name":"Eswar Kandaswamy"},{"name":"Tingyang Zhou"},{"name":"L. Zuo"}],"abstract":"The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages.","source":"Semantic Scholar","year":2018,"language":"en","subjects":["Medicine"],"doi":"10.3389/fphys.2018.00477","url":"https://www.semanticscholar.org/paper/5efae2551eb22bdcb7e06cf4499d72e0248a4a4f","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00477/pdf","is_open_access":true,"citations":737,"published_at":"","score":84.11},{"id":"ss_595e6f03f165403c1102c5468b70b8eb8c25d075","title":"American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients.","authors":[{"name":"J. Parrott"},{"name":"L. Frank"},{"name":"Rebecca Rabena"},{"name":"Lillian Craggs-Dino"},{"name":"K. Isom"},{"name":"Laura Greiman"}],"abstract":"","source":"Semantic Scholar","year":2017,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.soard.2016.12.018","url":"https://www.semanticscholar.org/paper/595e6f03f165403c1102c5468b70b8eb8c25d075","is_open_access":true,"citations":627,"published_at":"","score":79.81},{"id":"ss_cb3b0556d2cc4c0991e7b74bb5594f523a64494d","title":"Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies","authors":[{"name":"S. Kumar"},{"name":"Shanvanth R Arnipalli"},{"name":"P. Mehta"},{"name":"Silvia Carrau"},{"name":"O. Ziouzenkova"}],"abstract":"Iron deficiency anemia (IDA) has reached epidemic proportions in developing countries and has become a major global public health problem, affecting mainly 0–5-year-old children and young women of childbearing age, especially during pregnancy. Iron deficiency can lead to life-threatening loss of red blood cells, muscle function, and energy production. Therefore, the pathogenic features associated with IDA are weakness and impaired growth, motor, and cognitive performance. IDA affects the well-being of the young generation and the economic advancement of developing countries, such as India. The imbalance between iron intake/absorption/storage and iron utilization/loss culminates into IDA. However, numerous strategic programs aimed to increase iron intake have shown that improvement of iron intake alone has not been sufficient to mitigate IDA. Emerging critical risk factors for IDA include a composition of cultural diets, infections, genetics, inflammatory conditions, metabolic diseases, dysbiosis, and socioeconomic parameters. In this review, we discuss numerous IDA mitigation programs in India and their limitations. The new multifactorial mechanism of IDA pathogenesis opens perspectives for the improvement of mitigation programs and relief of IDA in India and worldwide.","source":"Semantic Scholar","year":2022,"language":"en","subjects":["Medicine"],"doi":"10.3390/nu14142976","url":"https://www.semanticscholar.org/paper/cb3b0556d2cc4c0991e7b74bb5594f523a64494d","pdf_url":"https://www.mdpi.com/2072-6643/14/14/2976/pdf?version=1658432938","is_open_access":true,"citations":208,"published_at":"","score":72.24000000000001},{"id":"ss_f6c3865b587ee26c77dd3df6fa31bd0dad3f8a43","title":"Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review","authors":[{"name":"P. Bhattacharya"},{"name":"S. Misra"},{"name":"Mohsina Hussain"}],"abstract":"Human body requires certain essential elements in small quantities and their absence or excess may result in severe malfunctioning of the body and even death in extreme cases because these essential trace elements directly influence the metabolic and physiologic processes of the organism. Rapid urbanization and economic development have resulted in drastic changes in diets with developing preference towards refined diet and nutritionally deprived junk food. Poor nutrition can lead to reduced immunity, augmented vulnerability to various oral and systemic diseases, impaired physical and mental growth, and reduced efficiency. Diet and nutrition affect oral health in a variety of ways with influence on craniofacial development and growth and maintenance of dental and oral soft tissues. Oral potentially malignant disorders (OPMD) are treated with antioxidants containing essential trace elements like selenium but even increased dietary intake of trace elements like copper could lead to oral submucous fibrosis. The deficiency or excess of other trace elements like iodine, iron, zinc, and so forth has a profound effect on the body and such conditions are often diagnosed through their early oral manifestations. This review appraises the biological functions of significant trace elements and their role in preservation of oral health and progression of various oral diseases.","source":"Semantic Scholar","year":2016,"language":"en","subjects":["Biology","Medicine"],"doi":"10.1155/2016/5464373","url":"https://www.semanticscholar.org/paper/f6c3865b587ee26c77dd3df6fa31bd0dad3f8a43","pdf_url":"http://downloads.hindawi.com/journals/scientifica/2016/5464373.pdf","is_open_access":true,"citations":406,"published_at":"","score":72.18},{"id":"ss_a8ba1342d52de232cb214b15db8755e83abc096a","title":"Millets: a solution to agrarian and nutritional challenges","authors":[{"name":"Ashwani Kumar"},{"name":"Vidisha Tomer"},{"name":"A. Kaur"},{"name":"Vikas Kumar"},{"name":"Kritika Gupta"}],"abstract":"World is facing agrarian as well as nutritional challenges. Agricultural lands with irrigation facilities have been exploited to maximum, and hence we need to focus on dry lands to further increase grain production. Owing to low fertility, utilization of dry lands to produce sufficient quality grains is a big challenge. Millets as climate change compliant crops score highly over other grains like wheat and rice in terms of marginal growing conditions and high nutritional value. These nutri-cereals abode vitamins, minerals, essential fatty acids, phyto-chemicals and antioxidants that can help to eradicate the plethora of nutritional deficiency diseases. Millets cultivation can keep dry lands productive and ensure future food and nutritional security.","source":"Semantic Scholar","year":2018,"language":"en","subjects":["Biology"],"doi":"10.1186/S40066-018-0183-3","url":"https://www.semanticscholar.org/paper/a8ba1342d52de232cb214b15db8755e83abc096a","pdf_url":"https://agricultureandfoodsecurity.biomedcentral.com/track/pdf/10.1186/s40066-018-0183-3","is_open_access":true,"citations":307,"published_at":"","score":71.21000000000001},{"id":"ss_fac85b3ac922176bca9820c310734a9023aa2c7a","title":"Nutritional status of patients with COVID-19","authors":[{"name":"J. Im"},{"name":"Y. Je"},{"name":"J. Baek"},{"name":"M. Chung"},{"name":"H. Kwon"},{"name":"Jin-soo Lee"}],"abstract":"The relationship between immunity and nutrition is well known and its role in coronavirus disease 2019 (COVID-19) is also being paid great attention. However, the nutritional status of COVID-19 patients is unknown. Vitamin B1, B6, B12, vitamin D (25-hydroxyvitamin D), folate, selenium, and zinc levels were measured in 50 hospitalized patients with COVID-19. Overall, 76% of the patients were vitamin D deficient and 42% were selenium deficient. No significant increase in the incidence of deficiency was found for vitamins B1, B6, and B12, folate, and zinc in patients with COVID-19. The COVID-19 group showed significantly lower vitamin D values than the healthy control group (150 people, matched by age/sex). Severe vitamin D deficiency (based on a cut-off of ≤10 ng/dl) was found in 24.0% of the patients in the COVID-19 group and 7.3% in the control group. Among 12 patients with respiratory distress, 11 (91.7%) were deficient in at least one nutrient. However, patients without respiratory distress showed a deficiency in 30/38 cases (78.9%; p =  0.425). These results suggest that a deficiency of vitamin D or selenium may decrease the immune defenses against COVID-19 and cause progression to severe disease. However, more precise and large-scale studies are needed.","source":"Semantic Scholar","year":2020,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.ijid.2020.08.018","url":"https://www.semanticscholar.org/paper/fac85b3ac922176bca9820c310734a9023aa2c7a","pdf_url":"https://doi.org/10.1016/j.ijid.2020.08.018","is_open_access":true,"citations":226,"published_at":"","score":70.78},{"id":"ss_b02d55e1c874717bb135b0f6431f02156bb809e4","title":"Main nutritional deficiencies","authors":[{"name":"A. K. Kiani"},{"name":"K. Dhuli"},{"name":"Kevin Donato"},{"name":"B. Aquilanti"},{"name":"V. Velluti"},{"name":"G. Matera"},{"name":"A. Iaconelli"},{"name":"S. Connelly"},{"name":"F. Bellinato"},{"name":"P. Gisondi"},{"name":"M. Bertelli"}],"abstract":"Summary Nutrition is the source of energy that is required to carry out all the processes of human body. A balanced diet is a combination of both macro- and micronutrients. “Nutritional inadequacy” involves an intake of nutrients that is lower than the estimated average requirement, whereas “nutritional deficiency” consists of severely reduced levels of one or more nutrients, making the body unable to normally perform its functions and thus leading to an increased risk of several diseases like cancer, diabetes, and heart disease. Malnutrition could be caused by environmental factors, like food scarcity, as well as disease conditions, like anorexia nervosa, fasting, swallowing inability, persistent vomiting, impaired digestion, intestinal malabsorption, or other chronic diseases. Nutritional biomarkers – like serum or plasma levels of nutrients such as folate, vitamin C, B vitamins, vitamin D, selenium, copper, zinc – could be used for the evaluation of nutrient intake and dietary exposure. Macronutrients deficiencies could cause kwashiorkor, marasmus, ketosis, growth retardation, wound healing, and increased infection susceptibility, whereas micronutrient – like iron, folate, zinc, iodine, and vitamin A – deficiencies lead to intellectual impairment, poor growth, perinatal complications, degenerative diseases associated with aging and higher morbidity and mortality. Preventing macro- and micronutrient deficiency is crucial and this could be achieved through supplementation and food-based approaches.","source":"Semantic Scholar","year":2022,"language":"en","subjects":["Medicine"],"doi":"10.15167/2421-4248/jpmh2022.63.2S3.2752","url":"https://www.semanticscholar.org/paper/b02d55e1c874717bb135b0f6431f02156bb809e4","is_open_access":true,"citations":152,"published_at":"","score":70.56},{"id":"doaj_10.1016/j.cdnut.2025.107230","title":"A 70 Amino Acid Fragment of Insparin Retains Its Potential to Upregulate Distal Insulin Signaling","authors":[{"name":"Tanvi Kale"},{"name":"Vijay Hegde"},{"name":"Nikhil V Dhurandhar"}],"abstract":"","source":"DOAJ","year":2025,"language":"","subjects":["Nutrition. Foods and food supply","Nutritional diseases. Deficiency diseases"],"doi":"10.1016/j.cdnut.2025.107230","url":"http://www.sciencedirect.com/science/article/pii/S2475299125026903","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.1186/s13098-025-01719-3","title":"The non-linear association between remnant cholesterol/high-density lipoprotein cholesterol ratio and diabetic retinopathy: a cross-sectional study in type 2 diabetic patients","authors":[{"name":"Cuimei Wei"},{"name":"Yaohui Huang"},{"name":"Ping Xi"},{"name":"Zhilan Shen"},{"name":"Wenjing Liu"},{"name":"Tong Li"},{"name":"Gang Chen"},{"name":"Xiaohua Xiao"},{"name":"Haofei Hu"}],"abstract":"Abstract Objective The strong correlation between the ratio of residual cholesterol to high-density lipoprotein cholesterol (RC/HDL-c) and major cardiovascular events has been extensively studied. However, the role of this ratio in diabetic retinopathy (DR) has not been investigated. Hence, this present study aims to examine the association between the RC/HDL-c ratio and DR in patients diagnosed with type 2 diabetes mellitus (T2DM). Methods This study conducted a cross-sectional analysis involving a total of 1942 patients diagnosed with T2DM in two Taiwanese hospitals, spanning from April 2002 to November 2004. The primary objective was to explore the independent association between the RC/HDL-c ratio and the presence of DR, as well as proliferative diabetic retinopathy (PDR), using a binary logistic regression model. To accurately determine the shape of the association between these variables, we utilized a generalized additive model (GAM) and employed smooth curve fitting techniques. The data was downloaded from the website: https://journals.plos.org/plosone . Results Our study comprised participants with an average age of 64.06 ± 11.32 years, with males accounting for 43.05% of the total. Among the patients, 35.12% were found to have DR, while PDR was present in 18.23% of cases. The average RC/HDL-c ratio was calculated as 0.67 ± 0.39. Utilizing a fully adjusted logistic regression model, we investigated the potential association between the TC/HDL-c ratio and both DR and PDR. However, no statistically significant association was observed (DR: OR 1.060; 95% CI 0.707, 1.588; PDR: OR 1.258; 95% CI 0.773, 2.047). Interestingly, we did discover a non-linear association between the RC/HDL-c ratio and DR. Employing a two-piece logistic regression model and a recursive algorithm, we identified an inflection point at 0.460. When the RC/HDL-c ratio fell below 0.460, each 1-unit increase in the ratio was associated with an 11.8-fold increase in the adjusted odds of developing DR (OR = 12.824; 95% CI 3.583, 45.897). Moreover, a non-linear association between the RC/HDL-c ratio and PDR was observed, with an inflection point occurring at 0.90. When the RC/HDL-c ratio was below 0.90, a one-unit increase in the ratio was linked to a 1.46-fold increase in the adjusted odds of PDR (OR = 2.459; 95% CI: 1.245, 4.857). Conclusion This study contributes valuable insights into the intricate association between the RC/HDL-c ratio and both DR and PDR in individuals diagnosed with T2DM. By identifying a non-linear association, our findings enhance the existing knowledge surrounding the link between the RC/HDL-c ratio and the development of DR and PDR.","source":"DOAJ","year":2025,"language":"","subjects":["Nutritional diseases. Deficiency diseases"],"doi":"10.1186/s13098-025-01719-3","url":"https://doi.org/10.1186/s13098-025-01719-3","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.3390/beverages11050129","title":"Correction: Abdi et al. Formulation Design and Functional Characterization of a Novel Fermented Beverage with Antioxidant, Anti-Inflammatory and Antibacterial Properties. \u003ci\u003eBeverages\u003c/i\u003e 2025, \u003ci\u003e11\u003c/i\u003e, 27","authors":[{"name":"Ameni Abdi"},{"name":"Emna Gatri"},{"name":"Pasquale Filannino"},{"name":"Sana M’Hir"},{"name":"Lamia Ayed"}],"abstract":"In the original publication [...]","source":"DOAJ","year":2025,"language":"","subjects":["Nutrition. Foods and food supply","Nutritional diseases. Deficiency diseases"],"doi":"10.3390/beverages11050129","url":"https://www.mdpi.com/2306-5710/11/5/129","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.1186/s41043-025-01084-x","title":"Analysis of TORCH screening and prenatal risk assessment for childbearing-age women in different regions of China","authors":[{"name":"Yuan Zhang"},{"name":"Ya Zhang"},{"name":"Jing Wang"},{"name":"Li Lin"},{"name":"Jian Chai"},{"name":"Jinmei Liu"},{"name":"Junxi Zhang"},{"name":"Yongmei Gao"},{"name":"Panpan Sun"},{"name":"Chenglong Wang"},{"name":"Lifang Jiang"},{"name":"Daoxia Li"},{"name":"Yingwu Zhang"},{"name":"Xiaofen Gu"},{"name":"Chaoyu Zhang"},{"name":"Yuanyuan Wang"},{"name":"Xu Ma"}],"abstract":"Abstract Objective By conducting TORCH screening and risk assessment analysis on childbearing-age women in different regions of China, the aim is to provide reference for reducing adverse pregnancy outcomes and improving the health status of childbearing-age women. Methods Between February and May 2021, in the eastern, central, and western regions of China (Beijing, Henan, Gansu), a total of 1,942 couples aged 18 to 49, from both urban and rural areas, were included in this cross-sectional study. TORCH screening was conducted on all these women of childbearing-age, and risk assessment was performed based on the examination results. Result In this study, toxoplasmosis, rubella, CMV, HSV, IgM positive rate were 0.2%, 0.4%, 0.3%, 0.3%, respectively, and CT, TP, HBsAg, HCV, HIV, positive rate were 0.1%, 0.2%, 2.1%, 0.3%, 0.0%, respectively. The total TORCH screening identified 63.4% of women as having potential risks, compared to 15.5% of routine ToRCH screening. The distribution of the risk population shows significant differences among provinces, ethnicities, education levels, and age groups (p ≤ 0.001). Trend chi-square tests revealed that as the level of education increased, the proportion of the risk population decreased. Conclusions The TORCH screening utilized in this study demonstrates advantages over ToRCH, as it can identify more women of childbearing age with potential risks before pregnancy, allowing for early interventions. Simultaneously, these findings underscore the necessity for targeted health education, especially for young women in economically underdeveloped areas and those with relatively lower education levels.","source":"DOAJ","year":2025,"language":"","subjects":["Nutritional diseases. Deficiency diseases","Public aspects of medicine"],"doi":"10.1186/s41043-025-01084-x","url":"https://doi.org/10.1186/s41043-025-01084-x","is_open_access":true,"published_at":"","score":69},{"id":"ss_a81259906d2414ac4604fb8fd34c481e3178dd8f","title":"Nutritional Aspects of Iron in Health and Disease","authors":[{"name":"Edouard Charlebois"},{"name":"K. Pantopoulos"}],"abstract":"Dietary iron assimilation is critical for health and essential to prevent iron-deficient states and related comorbidities, such as anemia. The bioavailability of iron is generally low, while its absorption and metabolism are tightly controlled to satisfy metabolic needs and prevent toxicity of excessive iron accumulation. Iron entry into the bloodstream is limited by hepcidin, the iron regulatory hormone. Hepcidin deficiency due to loss-of-function mutations in upstream gene regulators causes hereditary hemochromatosis, an endocrine disorder of iron overload characterized by chronic hyperabsorption of dietary iron, with deleterious clinical complications if untreated. The impact of high dietary iron intake and elevated body iron stores in the general population is not well understood. Herein, we summarize epidemiological data suggesting that a high intake of heme iron, which is abundant in meat products, poses a risk factor for metabolic syndrome pathologies, cardiovascular diseases, and some cancers. We discuss the clinical relevance and potential limitations of data from cohort studies, as well as the need to establish causality and elucidate molecular mechanisms.","source":"Semantic Scholar","year":2023,"language":"en","subjects":["Medicine"],"doi":"10.3390/nu15112441","url":"https://www.semanticscholar.org/paper/a81259906d2414ac4604fb8fd34c481e3178dd8f","pdf_url":"https://www.mdpi.com/2072-6643/15/11/2441/pdf?version=1684920948","is_open_access":true,"citations":61,"published_at":"","score":68.83},{"id":"ss_37c730c092fb29060278df9f42363fde834cbc4c","title":"Iron Deficiency Anemia in Children Residing in High and Low-Income Countries: Risk Factors, Prevention, Diagnosis and Therapy","authors":[{"name":"E. Mantadakis"}],"abstract":"Iron deficiency and iron-deficiency anemia (IDA) affects approximately two billion people worldwide, and most of them reside in low- and middle-income countries. In these nations, additional causes of anemia include parasitic infections like malaria, other nutritional deficiencies, chronic diseases, hemoglobinopathies, and lead poisoning. Maternal anemia in resource-poor nations is associated with low birth weight, increased perinatal mortality, and decreased work productivity. Maintaining a normal iron balance in these settings is challenging, as iron-rich foods with good bioavailability are of animal origin and either expensive and/or available in short supply. Apart from infrequent consumption of meat, inadequate vitamin C intake, and diets rich in inhibitors of iron absorption are additional important risk factors for IDA in low-income countries. In-home iron fortification of complementary foods with micronutrient powders has been shown to effectively reduce the risk of iron deficiency and IDA in infants and young children in developing countries but is associated with unfavorable changes in gut flora and induction of intestinal inflammation that may lead to diarrhea and hospitalization. In developed countries, iron deficiency is the only frequent micronutrient deficiency. In the industrialized world, IDA is more common in infants beyond the sixth month of life, in adolescent females with heavy menstrual bleeding, in women of childbearing age and older people. Other special at-risk populations for IDA in developed countries are regular blood donors, endurance athletes, and vegetarians. Several medicinal ferrous or ferric oral iron products exist, and their use is not associated with harmful effects on the overall incidence of infectious illnesses in sideropenic and/or anemic subjects. However, further research is needed to clarify the risks and benefits of supplemental iron for children exposed to parasitic infections in low-income countries, and for children genetically predisposed to iron overload.","source":"Semantic Scholar","year":2020,"language":"en","subjects":["Medicine"],"doi":"10.4084/MJHID.2020.041","url":"https://www.semanticscholar.org/paper/37c730c092fb29060278df9f42363fde834cbc4c","pdf_url":"https://www.mjhid.org/index.php/mjhid/article/download/2020.041/3791","is_open_access":true,"citations":152,"published_at":"","score":68.56},{"id":"doaj_10.1016/j.cdnut.2024.104444","title":"Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes","authors":[{"name":"Magdalena Sevilla-González"},{"name":"Maria Fernanda Garibay-Gutiérrez"},{"name":"Arsenio Vargas-Vázquez"},{"name":"Andrea Celeste Medina-García"},{"name":"Maria Luisa Ordoñez-Sánchez"},{"name":"Clary B Clish"},{"name":"Paloma Almeda-Valdes"},{"name":"Teresa Tusie-Luna"}],"abstract":"Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment responses is not well understood. Objectives: We aimed to determine the impact of the risk haplotype on the metabolomic profile during a lifestyle intervention (LSI). Methods: We recruited Mexican-mestizo individuals with ≥1 prediabetes criteria according to the American Diabetes Association with a body mass index between 25 and 45 kg/m2. We conducted a 24-wk quasiexperimental LSI study for diabetes prevention. Here, we compared longitudinal plasma liquid chromatography/mass spectrometry metabolomic changes between carriers and noncarriers. We analyzed the association of risk haplotype with metabolites leveraging repeated assessments using multivariable-adjusted linear mixed models. Results: Before the intervention, carriers (N = 21) showed higher concentrations of hippurate, C16 carnitine, glycine, and cinnamoylglycine. After 24 wk of LSI, carriers exhibited a deleterious metabolomic profile. This profile was characterized by increased concentrations of hippurate, cinnamoglycine, xanthosine, N-acetylputrescine, L-acetylcarnitine, ceramide (d18:1/24:1), and decreased concentrations of citrulline and phosphatidylethanolamine. These metabolites were associated with higher concentrations of total cholesterol, triglycerides, and low density lipoprotein cholesterol. The effect of LSI on the risk haplotype was notably more pronounced in its impact on 2 metabolites: methylmalonylcarnitine (β: −0.56; P-interaction = 0.014) and betaine (β: −0.64; P-interaction = 0.017). Interestingly, lower consumption across visits of polyunsaturated (β: −0.038; P = 0.017) fatty acids were associated with higher concentrations of methylmalonylcarnitine. Covariates for adjustment across models included age, sex, genetic ancestry principal components, and body mass index. Conclusions: Our study highlights the persistence of deleterious metabolomic patterns associated with the risk haplotype before and during a 24-wk LSI. We also emphasize the potential regulatory role of polyunsaturated fatty acids on methylmalonylcarnitine concentrations suggesting a route for improving interventions for individuals with high-genetic risk.","source":"DOAJ","year":2024,"language":"","subjects":["Nutrition. Foods and food supply","Nutritional diseases. Deficiency diseases"],"doi":"10.1016/j.cdnut.2024.104444","url":"http://www.sciencedirect.com/science/article/pii/S2475299124023783","is_open_access":true,"published_at":"","score":68},{"id":"ss_4ff3995464e3d94442648a98764c8c10a0a8ae5c","title":"Hybrid models based on genetic algorithm and deep learning algorithms for nutritional Anemia disease classification","authors":[{"name":"Serhat Kılıçarslan"},{"name":"Mete Çelik"},{"name":"Ş. Şahin"}],"abstract":"Abstract Deep learning algorithms are an important part of disease prediction and diagnosis by analyzing health data. If not diagnosed and treated early, symptoms of nutritional anemia can be seen as a common laboratory finding of dyspnea, dizziness, lack of concentration, pale skin color, and life-threatening diseases. In the literature, several data mining techniques have been used for the prediction of nutritional anemia, especially, for the iron deficiency anemia. However, each algorithm does not perform well for every data, and therefore new techniques need to be developed. It is because the characteristics of each dataset are different and their dataset sizes, that is, the number of records and the number of parameters are different. In this study, we propose two hybrid models using genetic algorithm (GA) and deep learning algorithms of Stacked Autoencoder (SAE) and Convolutional Neural Network (CNN) for the prediction of HGB-anemia, nutritional anemia, (iron deficiency anemia, B12 deficiency anemia, and folate deficiency anemia), and patients without anemia. In the proposed GA-SAE and GA-CNN models, the hyperparameters of SAE and CNN algorithms are optimized using GA since it is not easy to determine suitable values of deep learning algorithms. Accuracy, F-score, precision, and sensitivity criteria were used to evaluate the prediction and classification performances of the proposed algorithms. As a result of the experimental evaluations using the dataset, the performance of the proposed GA-CNN algorithm whose layers trained separately and sequentially was found to be better than the performance of the studies proposed in the literature, by a 98.50% accuracy.","source":"Semantic Scholar","year":2021,"language":"en","subjects":["Computer Science"],"doi":"10.1016/j.bspc.2020.102231","url":"https://www.semanticscholar.org/paper/4ff3995464e3d94442648a98764c8c10a0a8ae5c","is_open_access":true,"citations":98,"published_at":"","score":67.94},{"id":"ss_e10bd997e9090e165b58d65298d8d3b69e9eac27","title":"Deep Learning Based Disease, Pest Pattern and Nutritional Deficiency Detection System for “Zingiberaceae” Crop","authors":[{"name":"Hamna Waheed"},{"name":"Noureen Zafar"},{"name":"Waseem Akram"},{"name":"Awais Manzoor"},{"name":"Abdullah Gani"},{"name":"S. M. Fakhrul Islam"}],"abstract":"Plants’ diseases cannot be avoided because of unpredictable climate patterns and environmental changes. The plants like ginger get affected by various pests, conditions, and nutritional deficiencies. Therefore, it is essential to identify such causes early and perform the cure to get the desired production rate. Deep learning-based methods are helpful for the identification and classification of problems in this domain. This paper presents deep artificial neural network and deep learning-based methods for the early detection of diseases, pest patterns, and nutritional deficiencies. We have used a real-field dataset consisting of healthy and affected ginger plant leaves. The results show that the convolutional neural network (CNN) has achieved the highest accuracy of 99% for disease rhizomes detection. For pest pattern leaves, VGG-16 models showed the highest accuracy of 96%. For nutritional deficiency-affected leaves, ANN has achieved the highest accuracy (96%). The experimental results achieved are comparable with other existing techniques in the literature. In addition, the results demonstrated the potential in improving the yield of ginger using the proposed disease detection methods and an essential consideration for the design of real-time disease detection applications. However, the results are specific to the dataset used in this work and may yield different results for the other datasets.","source":"Semantic Scholar","year":2022,"language":"en","subjects":null,"doi":"10.3390/agriculture12060742","url":"https://www.semanticscholar.org/paper/e10bd997e9090e165b58d65298d8d3b69e9eac27","pdf_url":"https://www.mdpi.com/2077-0472/12/6/742/pdf?version=1653540889","is_open_access":true,"citations":40,"published_at":"","score":67.2},{"id":"doaj_10.47320/rasbran.2023.2956","title":"Risco de síndrome de realimentação e desfechos clínicos em pacientes de prontos socorros do Distrito Federal ","authors":[{"name":"Nathália Leal Dominguez"},{"name":"Thaís Amaral Ferreira Baracho"},{"name":"Bruna de Abreu Toscano Souza"},{"name":"Maíra  Silveira Coelho"},{"name":"Luana Clemente de Oliveira Mota"},{"name":"Michelle Estefany de Conceição de Pádua"},{"name":"Davi Domineo Moreira de Araújo"},{"name":"Pedro de Lima Ramos"}],"abstract":"\nObjetivo: Avaliar a relação do risco de síndrome de realimentação com desfechos clínicos (tempo de internação e óbito) em pacientes admitidos nos prontos socorros de dois hospitais públicos do Distrito Federal (DF). Método: Trata-se de um estudo com caráter longitudinal, prospectivo, observacional e analítico, o qual foi realizado em dois hospitais públicos do DF no período de agosto de 2018 a agosto de 2019. Resultados: A amostra foi composta por 478 pacientes admitidos nos prontos-socorros dos dois hospitais. Observou-se que 45,60% da amostra apresentou risco nutricional e 32,22% algum grau de desnutrição. A frequência do risco para síndrome de realimentação foi de 23,65%. Os pacientes que apresentaram risco para síndrome de realimentação apresentaram 83% mais risco de permanecerem internados por mais de 7 dias e 58% mais risco de óbito em relação aos pacientes que não apresentaram risco para SR. Conclusão: Pacientes que apresentam risco para síndrome de realimentação permaneceram mais tempo internados e possuem mais risco de irem a óbito.\n","source":"DOAJ","year":2023,"language":"","subjects":["Nutritional diseases. Deficiency diseases","Nutrition. Foods and food supply","Food processing and manufacture"],"doi":"10.47320/rasbran.2023.2956","url":"https://www.rasbran.com.br/rasbran/article/view/2956","is_open_access":true,"published_at":"","score":67},{"id":"doaj_10.1186/s12944-023-01808-0","title":"Development and validation of an online dynamic nomogram based on the atherogenic index of plasma to screen nonalcoholic fatty liver disease","authors":[{"name":"Hewei Peng"},{"name":"Junchao Zhang"},{"name":"Xianhua Huang"},{"name":"Miao Xu"},{"name":"Jingru Huang"},{"name":"Yunli Wu"},{"name":"Xian-E. Peng"}],"abstract":"Abstract Background Nonalcoholic fatty liver disease (NAFLD), a common liver disease worldwide, can be reversed early in life with lifestyle and medical interventions. This study aimed to develop a noninvasive tool to screen NAFLD accurately. Methods Risk factors for NAFLD were identified using multivariate logistic regression analysis, and an online NAFLD screening nomogram was developed. The nomogram was compared with reported models (fatty liver index (FLI), atherogenic index of plasma (AIP), and hepatic steatosis index (HSI)). Nomogram performance was evaluated through internal and external validation (National Health and Nutrition Examination Survey (NHANES) database). Results The nomogram was developed based on six variables. The diagnostic performance of the present nomogram for NAFLD (area under the receiver operator characteristic curve (AUROC): 0.863, 0.864, and 0.833, respectively) was superior to that of the HSI (AUROC: 0.835, 0.833, and 0.810, respectively) and AIP (AUROC: 0.782, 0.773, and 0.728, respectively) in the training, validation, and NHANES sets. Decision curve analysis and clinical impact curve analysis presented good clinical utility. Conclusion This study establishes a new online dynamic nomogram with excellent diagnostic and clinical performance. It has the potential to be a noninvasive and convenient method for screening individuals at high risk for NAFLD.","source":"DOAJ","year":2023,"language":"","subjects":["Nutritional diseases. Deficiency diseases"],"doi":"10.1186/s12944-023-01808-0","url":"https://doi.org/10.1186/s12944-023-01808-0","is_open_access":true,"published_at":"","score":67},{"id":"ss_512d40dd6765de3fb466059b04777ee271d88caa","title":"Nutritional Deficiency Disease Secondary to ARFID Symptoms Associated with Autism and the Broad Autism Phenotype: A Qualitative Systematic Review of Case Reports and Case Series.","authors":[{"name":"S. Yule"},{"name":"J. Wanik"},{"name":"Elizabeth Holm"},{"name":"M. Bruder"},{"name":"E. Shanley"},{"name":"Christina Sherman"},{"name":"Megan Fitterman"},{"name":"J. Lerner"},{"name":"M. Marcello"},{"name":"Nicole Parenchuck"},{"name":"Corinne Roman-White"},{"name":"Madeline Ziff"}],"abstract":"BACKGROUND The demographics, weight statuses, and dietary patterns of people with autism or the broad autism phenotype who experience a severe nutrient deficiency disease due to symptoms of avoidant/restrictive food intake disorder have not been well established. OBJECTIVE The primary objective of this review was to examine the relationship between the demographics, weight statuses, dietary patterns, and nutrient deficiency diseases that characterize the most severe manifestations of avoidant/restrictive food intake disorder symptomology associated with autism or the broad autism phenotype. METHODS A systematic review of English and non-English articles published up to August 29, 2019, on the Scopus, PubMed, and Cumulative Index to Nursing and Allied Health Literature Plus electronic databases was conducted. Additional cases were identified through the reference list of all included articles. The search terms used were \"autis∗ AND (deficiency OR scurvy)\". Only case reports or case series in which a person of any age who had been identified as having a formal diagnosis of autism or autism symptoms and a disease of nutritional deficiency due to self-imposed dietary restrictions were included. Data were independently extracted by 8 authors using predefined data fields. RESULTS A total of 76 cases (patients were aged 2.5 to 17 years) from 63 articles that were published from 1993 through 2019 were found. More than 85% cases (65 of 76 patients) were from articles published in the past 10 years. The largest percentage of published cases (69.7% [53 of 76]) involved scurvy, a vitamin C deficiency. The second-largest percentage of published cases (17.1% [13 of 76]) involved eye disorders secondary to vitamin A deficiency. Other primary nutrient deficiencies reported were thiamin, vitamin B-12, and vitamin D. In 62.9% (22 of 35) of the patients for which a body mass index or a weight percentile for age was provided, the patient was within normal weight parameters, per Centers for Disease Control weight status categories. CONCLUSIONS Based on the 63 articles extracted for this systematic review, nutritional deficiency diseases related to inadequate intakes of vitamin A, thiamin, vitamin B-12, vitamin C, and vitamin D were found in individuals with autism and the broad autism phenotype who had severe self-imposed dietary restrictions. When weight information was provided, most of the youth in these cases were not reported to be underweight. Individuals of any weight who present with symptoms of avoidant/restrictive food intake disorder can benefit from early and frequent screening for adequacy of micronutrient intake, regardless of whether they have a clinical diagnosis of autism.","source":"Semantic Scholar","year":2020,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.jand.2020.10.017","url":"https://www.semanticscholar.org/paper/512d40dd6765de3fb466059b04777ee271d88caa","is_open_access":true,"citations":72,"published_at":"","score":66.16},{"id":"doaj_10.3390/dietetics2010001","title":"Diet Quality, Nutritional Adequacy and Anthropometric Status among Indigenous Women of Reproductive Age Group (15–49 Years) in India: A Narrative Review","authors":[{"name":"Ridhima Kapoor"},{"name":"Manisha Sabharwal"},{"name":"Suparna Ghosh-Jerath"}],"abstract":"In India, indigenous communities are nutritionally vulnerable, with indigenous women suffering the greater burden. Studies and surveys have reported poor nutritional outcomes among indigenous women in India, yet systematic documentation of community-specific nutrition data is lacking. We conducted a narrative review of 42 studies to summarise the nutritional profile of indigenous women of India, with details on their food and nutrient intakes, dietary diversity, traditional food consumption and anthropometric status. Percentage deficits were observed in intake of pulses, green leafy vegetables, fruits, vegetables, flesh foods and dairy products when compared with recommended dietary intakes for moderately active Indian women. Indices of diet quality in indigenous women were documented in limited studies, which revealed poor dietary diversity as well as low consumption of diverse traditional foods. A high risk of nutritional inadequacy was reported in all communities, especially for iron, calcium, and vitamin A. Prevalence of chronic energy deficiency was high in most communities, with dual burden of malnutrition in indigenous women of north-eastern region. Findings from this review can thus help guide future research and provide valuable insights for policymakers and program implementers on potential interventions for addressing specific nutritional issues among indigenous women of India.","source":"DOAJ","year":2022,"language":"","subjects":["Nutritional diseases. Deficiency diseases"],"doi":"10.3390/dietetics2010001","url":"https://www.mdpi.com/2674-0311/2/1/1","is_open_access":true,"published_at":"","score":66}],"total":2022728,"page":1,"page_size":20,"sources":["CrossRef","DOAJ","Semantic Scholar"],"query":"Nutritional diseases. Deficiency diseases"}