{"results":[{"id":"doaj_10.1186/s12989-025-00657-2","title":"Associations of prenatal fine particulate matter mixtures with neurodevelopmental outcomes in early childhood: component- and source-specific insights","authors":[{"name":"Haonan Li"},{"name":"Elizabeth A. Holzhausen"},{"name":"Devendra Paudel"},{"name":"Nathan D. Young"},{"name":"Jonatan Ottino-González"},{"name":"Frederick W. Lurmann"},{"name":"Douglas I. Walker"},{"name":"Howard H. Chang"},{"name":"Donghai Liang"},{"name":"Ravi Bansal"},{"name":"Michael I. Goran"},{"name":"Bradley S. Peterson"},{"name":"Tanya L. Alderete"}],"abstract":"Abstract This study investigates independent and joint effects of fine particulate matter (PM2.5) components on early childhood neurodevelopment and explores emission sources of key toxic components. We included 165 mother-infant dyads from Southern California. Annual average concentrations of 15 PM2.5 components, including carbonaceous components, secondary inorganic salts, and trace elements, were estimated for the birth year. Neurodevelopment across cognitive, language, motor, social-emotional, and adaptive behavior domains was assessed at age 2 using Bayley-III Scales. Mixture effects and key contributors were evaluated using weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR). Source inference was conducted through inter-component clustering and spatial analysis. Linear regression showed PM2.5, sulfate (SO4 2−), nitrate (NO3 −), ammonium (NH4 +), copper (Cu), nickel (Ni), lead (Pb), and vanadium (V) were inversely, while calcium (Ca) and zinc (Zn) were positively, associated with adaptive behavior scores (p \u003c 0.05). WQS showed negative associations between the mixture and adaptive behavior (p = 0.02–0.06), with Ni, Cu, V, and SO₄²⁻ as key contributors. BKMR showed similar trends. Ni, V, and SO4 2− likely originate from heavy oil combustion, and Cu from brake wear. Findings suggest that PM2.5 components, particularly from traffic and marine fuel combustion, may adversely affect adaptive behavior in early childhood.","source":"DOAJ","year":2026,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-025-00657-2","url":"https://doi.org/10.1186/s12989-025-00657-2","is_open_access":true,"published_at":"","score":70},{"id":"ss_aab607fa9822f540a2b1f06e5617ec676ee5dfea","title":"THE SCIENTIFIC ACTIVITIES OF ALL-RUSSIAN RESEARCH INSTITUTE OF VETERINARY SANITATION, HYGIENE AND ECOLOGY FOR STATE ASSIGNMENT FOR 2025","authors":[{"name":"Petr A. Popov"},{"name":"A. Smirnov"},{"name":"N. K. Gunenkova"},{"name":"N. I. Popov"}],"abstract":"The article presents the results of research for 2025 aimed at ensuring sustainable veterinary and sanitary welfare of livestock farming, biological and food safety of livestock products and feed, and environmental protection from pollution by ecotoxicants. The state task for 2025 has been fully completed. 8 technologies and instructions, 8 methodological recommendations, and technological scheme for disinfection of veterinary surveillance facilities have been developed and approved in accordance with the established procedure; 5 monographs, 3 textbooks for universities and one lecture have been published. They were awarded a Silver medal and a Diploma of the Russian Agro-industrial Exhibition “Golden Autumn 2025”.The monographs “On the 80th Anniversary of Victory in the Great Patriotic War” dedicated to the employees of the All-Russian Research Institute of Veterinary Sanitation, Hygiene, and Ecology, who contributed to the Great Victory,” “Biological Safety: Means and Methods of Protection against Pathogenic Biological Agents,” “Commodity Science and Standardization of Veterinary Medicines,” and “Veterinary and Sanitary Requirements and Measures to Ensure the Safety of Poultry Eggs for Food Purposes” were awarded the Silver Medal and Diploma of the Russian Agro-Industrial Exhibition “Golden Autumn 2025.” State Standard Samples (SSS) of mycotoxins were produced for 136 applications, and ELISA test systems were developed for 26 applications from various republics and regions of the Russian Federation. Feed was tested for four applications. In the reporting year, the institute’s staff published 145 scientific papers, including 112 within the framework of the State Contract, 9 in Scopus, 75 in RSCI, 93 in RINTS, 6 in AGRIS, 102 in the White List, and 84 in the VAK list. 4 issues of the Russian Journal “Problems of Veterinary Sanitation, Hygiene and Ecology” (included in RSCI, RSCI, RSCI core, AGRIS, White List, Metaphor System, HAC list) and the collection of scientific papers “Problems of Veterinary Sanitation, Hygiene and Ecology”, volume 123 (included in RSCI) have been published.","source":"Semantic Scholar","year":2026,"language":"en","subjects":null,"doi":"10.36871/vet.san.hyg.ecol.202601001","url":"https://www.semanticscholar.org/paper/aab607fa9822f540a2b1f06e5617ec676ee5dfea","is_open_access":true,"published_at":"","score":70},{"id":"doaj_10.1186/s12989-025-00633-w","title":"Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis","authors":[{"name":"Yinuo Chen"},{"name":"Yiyang Nan"},{"name":"Lang Xu"},{"name":"Anqi Dai"},{"name":"Rosa Maria Martinez Orteg"},{"name":"Mantong Ma"},{"name":"Yan Zeng"},{"name":"Jinquan Li"}],"abstract":"Abstract Background Recent studies emphasize the significance of copper dyshomeostasis in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, thereby highlighting the role of copper in neurotoxicity. Cuproptosis, a novel mechanism of copper-dependent cell death, remains underexplored, particularly concerning environmental pollutants like polystyrene nanoplastics (PS-NPs). While PS-NPs are recognized for inducing neurotoxicity through various forms of cell death, including apoptosis and ferroptosis, their potential to trigger neuronal cuproptosis has not yet been investigated. This study aims to determine whether exposure to PS-NPs induces neurotoxicity via cuproptosis and to explore the preliminary molecular mechanisms involved, thereby addressing this significant knowledge gap. Methods Seven-week-old male C57BL/6 mice were exposed to PS-NPs at dose of 12.5 mg/kg, and were co-treated with the antioxidant N-acetylcysteine (NAC). Complementary in vitro experiments were conducted using SH-SY5Y neuronal cells exposed to PS-NPs at a concentration of 0.75 mg/mL, with interventions that included the copper chelator tetrathiomolybdate (TTM), NAC, and the MAPK inhibitor PD98059. Results Exposure to PS-NPs significantly increased cerebral copper accumulation (P \u003c 0.05) and induced cuproptosis, characterized by lipid-acylated DLAT oligomerization, dysregulation of cuproptosis regulators (FDX1, LIAS, HSP70), and mitochondrial damage. In murine models, PS-NPs elicited neurotoxicity, as evidenced by neuronal loss, decreased Nissl body density, impaired synaptic plasticity, and suppressed oxidative stress markers (GSH, SOD, Nrf2), alongside activation of the ERK-MAPK pathway, ultimately resulting in deficits in learning and memory. Treatment with NAC alleviated these adverse effects. In SH-SY5Y cells, exposure to PS-NPs resulted in reduced cell viability (p \u003c 0.01), an effect that was mitigated by TTM. Furthermore, NAC and PD98059 were found to reverse elevated copper levels, cuproptosis markers, and mitochondrial anomalies (p \u003c 0.05). Conclusion This study presents preliminary evidence indicating that PS-NPs may induce neuronal cuproptosis, potentially through the oxidative stress-mediated activation of the ERK-MAPK pathway, which contributes to cognitive dysfunction in mice. These findings provide insights into the potential mechanisms underlying PS-NPs neurotoxicity and highlight possible therapeutic targets, such as copper chelation or MAPK inhibition, for mitigating the neurological risks associated with nanoplastic exposure, pending further validation in human-relevant models.","source":"DOAJ","year":2025,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-025-00633-w","url":"https://doi.org/10.1186/s12989-025-00633-w","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.1186/s12989-024-00616-3","title":"Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis","authors":[{"name":"Jiayu Cao"},{"name":"Yuhui Yang"},{"name":"Xi Liu"},{"name":"Yang Huang"},{"name":"Qianqian Xie"},{"name":"Aliaksei Kadushkin"},{"name":"Mikhail Nedelko"},{"name":"Di Wu"},{"name":"Noel J. Aquilina"},{"name":"Xuehua Li"},{"name":"Xiaoming Cai"},{"name":"Ruibin Li"}],"abstract":"Abstract Background The advancement of nanotechnology underscores the imperative need for establishing in silico predictive models to assess safety, particularly in the context of chronic respiratory afflictions such as lung fibrosis, a pathogenic transformation that is irreversible. While the compilation of predictive descriptors is pivotal for in silico model development, key features specifically tailored for predicting lung fibrosis remain elusive. This study aimed to uncover the essential predictive descriptors governing nanoparticle-induced pulmonary fibrosis. Methods We conducted a comprehensive analysis of the trajectory of metal oxide nanoparticles (MeONPs) within pulmonary systems. Two biological media (simulated lung fluid and phagolysosomal simulated fluid) and two cell lines (macrophages and epithelial cells) were meticulously chosen to scrutinize MeONP behaviors. Their interactions with MeONPs, also referred to as nano-bio interactions, can lead to alterations in the properties of the MeONPs as well as specific cellular responses. Physicochemical properties of MeONPs were assessed in biological media. The impact of MeONPs on cell membranes, lysosomes, mitochondria, and cytoplasmic components was evaluated using fluorescent probes, colorimetric enzyme substrates, and ELISA. The fibrogenic potential of MeONPs in mouse lungs was assessed by examining collagen deposition and growth factor release. Random forest classification was employed for analyzing in chemico, in vitro and in vivo data to identify predictive descriptors. Results The nano-bio interactions induced diverse changes in the 4 characteristics of MeONPs and had variable effects on the 14 cellular functions, which were quantitatively evaluated in chemico and in vitro. Among these 18 quantitative features, seven features were found to play key roles in predicting the pro-fibrogenic potential of MeONPs. Notably, IL-1β was identified as the most important feature, contributing 27.8% to the model’s prediction. Mitochondrial activity (specifically NADH levels) in macrophages followed closely with a contribution of 17.6%. The remaining five key features include TGF-β1 release and NADH levels in epithelial cells, dissolution in lysosomal simulated fluids, zeta potential, and the hydrodynamic size of MeONPs. Conclusions The pro-fibrogenic potential of MeONPs can be predicted by combination of key features at nano-bio interfaces, simulating their behavior and interactions within the lung environment. Among the 18 quantitative features, a combination of seven in chemico and in vitro descriptors could be leveraged to predict lung fibrosis in animals. Our findings offer crucial insights for developing in silico predictive models for nano-induced pulmonary fibrosis.","source":"DOAJ","year":2025,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-024-00616-3","url":"https://doi.org/10.1186/s12989-024-00616-3","is_open_access":true,"published_at":"","score":69},{"id":"ss_e31d52d35f24934dc7c1fc17ea5fb2129fa77f49","title":"Human amenities and post-colonial welfares: An Indian coalfield, 1946–1972","authors":[{"name":"Debasree Dhar"}],"abstract":"This article elaborates on the new wellbeing discourse developed from the mid-1940s that concerned itself with providing human amenities to mineworkers to improve their health, morale, and, in turn, efficiency on the Indian coal mines. This wellbeing practice brought about new institutional machinery, called Coal Mines Labour Welfare Organisation, which was jointly managed by the representatives of the state, organised labour and colliery management since 1946. The wellbeing practice prioritised the issue of housing, drinking water, sanitation and hygiene, crèche, canteen, education and awareness campaign. Some of these measures registered impressive advancement while others remained more on paper with actual provision of the above taking much longer. Mineworkers saw that the record of human amenities as a whole was insufficient, unsatisfactory and half-hearted during 1946 to 1972. The financial anxiety and unfavourable social priority of labour-intensive colliery firms, on one side, and the humane desire of workers and the promise of state welfare were at loggerheads. This manifested in the problem of allocation of funds and its improper utilisation, anxiety-related to the material cost, and the very loophole in the ‘protective’ labour laws.","source":"Semantic Scholar","year":2025,"language":"en","subjects":null,"doi":"10.1177/00221856251326680","url":"https://www.semanticscholar.org/paper/e31d52d35f24934dc7c1fc17ea5fb2129fa77f49","is_open_access":true,"published_at":"","score":69},{"id":"doaj_10.20473/ijosh.v13i1.2024.53-64","title":"Safety Perceptions among Ship-to-Shore (STS) Crane Operators at PT Terminal Teluk Lamong","authors":[{"name":"Sentagi Sesotya  Utami"},{"name":"Winny  Setyonugroho"},{"name":"Moch Zihad  Islami"},{"name":"Iman  Permana"},{"name":"Janatarum  Srihandono"},{"name":"Tipung  Muljoko"}],"abstract":"Introduction: Ship-to-shore (STS) crane operators strive for efficiency in their work, but they must take a hard look at their high-risk jobs. It is necessary to learn how to improve occupational safety and health. This study aims to investigate the problems faced by STS crane operators working in container ports and to understand the importance of fit-for-work monitoring procedures, particularly for individuals working in high-risk industries such as STS operators. Methods: This study used a qualitative approach, and data were collected through interviews and observations of STS operators and in-house clinic staff. Nine STS operators, two in-house clinic staff, and two safety, health, and environment (SHE) staff were interviewed. Results: This study found that container terminal companies emphasise two critical aspects for STS operators: productivity and occupational safety and health. STS operators face health problems, including physical and psychological problems, due to the fast-paced work system, sleep patterns, daily activities, and thoughts that are difficult to control. Employees have coping mechanisms to deal with fatigue, and stakeholders have effectively communicated the company's safety and health culture. Most stakeholders in a container terminal company want a fit-for-work monitoring system to make the business efficient and sustainable. Conclusion: The STS industry faces a significant problem with operator fatigue, which can negatively impact safety and productivity. This issue requires a comprehensive strategy, including legislation to regulate working hours and shift patterns, technology to combat fatigue, and operator education and training.","source":"DOAJ","year":2024,"language":"","subjects":["Industrial safety. Industrial accident prevention","Industrial hygiene. Industrial welfare"],"doi":"10.20473/ijosh.v13i1.2024.53-64","url":"https://e-journal.unair.ac.id/IJOSH/article/view/44369","is_open_access":true,"published_at":"","score":68},{"id":"doaj_10.20473/ijosh.v13i2.2024.222-228","title":"Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of  Covid-19 among Health-Care Workers","authors":[{"name":"Alka  Verma"},{"name":"Amit Goel"},{"name":"Priyank Yadav"},{"name":"Awale Rupali  Bhalchandra"},{"name":"Dheeraj Khetan"},{"name":"Om P Sanjeev"},{"name":"Mallikarjun Gunjiganvi"}],"abstract":"Introduction: Limited information is available regarding effect of vaccination on protection against Covid-19 infections and their severity as well. Objectives: In the present study, we assessed the effect of Covid-19 vaccination on incidences and severity of break through Covid-19 infections. Method: This retrospective study was conducted at a tertiary care center in Northern India during one calendar year, 1st August 2021 to 31st July 2022. The study population included Health-care workers (HCWs) who were treated for Covid 19 infection and had already received at least 1 dose of Covishield TM (AZD1222) Covid-19 vaccine. Results: Out of 1868 health care workers enrolled for the study, 513 contracted Covid-19 infections. Amongst infected HCWs, number of single and double doses of CovishieldTM (AZD1222) recipients were 112 and 401 respectively. Out of the 513 covid positive HCWs, 459 (89.4%) had mild disease, whereas 54 (10.6%) had moderate disease. None of the HCWs developed severe disease and no mortality was noted in either group. Conclusion: In this study, we found that immunization with two doses of CovishieldTM (AZD1222) vaccine was associated with decline in number of cases with moderate or severe Covid-19. Moreover, immunization with even single dose of CovishieldTM (AZD1222) vaccine prevented development of severe disease. Henceforth, it is concluded that although, immunization with CovishieldTM (AZD1222) could not protect all recipients from SARS-Cov-2 infection, it did prevent the progress of disease to severe grades.","source":"DOAJ","year":2024,"language":"","subjects":["Industrial safety. Industrial accident prevention","Industrial hygiene. Industrial welfare"],"doi":"10.20473/ijosh.v13i2.2024.222-228","url":"https://e-journal.unair.ac.id/IJOSH/article/view/45637","is_open_access":true,"published_at":"","score":68},{"id":"doaj_Gesti%C3%B3n+estrat%C3%A9gica+de+los+riesgos+de+Seguridad+y+Salud+en+el+Trabajo+Strategic+management+of+Occupational+Health+and+Safety+risks","title":"Gestión estratégica de los riesgos de Seguridad y Salud en el Trabajo Strategic management of Occupational Health and Safety risks","authors":[{"name":"Idalmis Acosta Pérez "},{"name":"Fernando Marrero Delgado  "},{"name":"José Ángel Espinosa Acosta  "},{"name":"Luis Darién Rivero Rodríguez "},{"name":"Dayana Ramírez Lara "}],"abstract":"Introducción: La inclusión de la gestión de riesgos de Seguridad y Salud en el Trabajo en la planificación estratégica constituye una herramienta necesaria para que la organización pueda anticiparse y mitigar posibles amenazas e identificar oportunidades para el crecimiento y la mejora continua.\r\nObjetivo: Diseñar un procedimiento, científicamente fundamentado, que permita la inclusión de la gestión de riesgos de Seguridad y Salud dentro de la proyección estratégica, en aras de mejorar el sistema de gestión y por ende, el entorno laboral y las condiciones de trabajo.\r\nMétodos: Incluyó el diseño de un procedimiento para la gestión estratégica de los riesgos de Seguridad y Salud, con una secuencia lógica de cuatro fases, que incluye métodos empíricos como el criterio de expertos y revisión de la documentación legal en materia de gestión de riesgo. Además, el procedimiento contiene pasos para la realización de un diagnostico estratégico donde se definen la política y la filosofía en materia de gestión de riesgos, se identifican los riesgos y se evalúan según la severidad, ocurrencia y detectatibilidad, para luego calcular el Nivel del Prioridad del Riesgo (NPR).\r\nResultados: Se logró la inclusión de los riesgos de Seguridad y Salud desde la planificación estratégica, además, se conoce el Nivel de Percepción de Convergencia Estratégica en la Gestión de Riesgos de SST (NCERSST).\r\nConclusiones: El procedimiento diseñado permitirá identificar las principales debilidades que presenta la organización relacionada con la gestión estratégica de sus riesgos\r\n\r\nIntroduction: The inclusion of Occupational Health and Safety risk management in strategic planning constitutes a necessary tool so that the organization can anticipate and mitigate possible threats and identify opportunities for growth and continuous improvement.\r\nObjective: To design a scientifically based procedure, which allows the inclusion of Health and Safety risk management within the strategic projection, in order to improve the management system and therefore, the work environment and the working conditions.\r\nMethods: Included the design of a procedure for the strategic management of Health and Safety risks, with a logical sequence of four phases, which includes empirical methods such as expert judgment and review of legal documentation on risk management. In addition, the procedure includes steps to carry out a strategic diagnosis where the policy and philosophy regarding risk management are defined, risks are identified and evaluated according to severity, occurrence and detectability, and then calculate the Priority Level of Risk (PLR).\r\nResults: The inclusion of Health and Safety risks is achieved from the strategic planning, in addition, the Level of Perception of Strategic Convergence in (Security and health at work) Risk Management (NCERSST) is known.\r\nConclusions: The designed procedure will allow identifying the main weaknesses that the organization presents related to the strategic management of its risks","source":"DOAJ","year":2024,"language":"","subjects":["Medicine (General)","Industrial hygiene. Industrial welfare"],"url":"http://revsaludtrabajo.sld.cu/index.php/revsyt/article/view/627","is_open_access":true,"published_at":"","score":68},{"id":"doaj_10.1186/s12989-024-00582-w","title":"Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes","authors":[{"name":"Yunyi Wang"},{"name":"Ke Xu"},{"name":"Xiao Gao"},{"name":"Zhaolan Wei"},{"name":"Qi Han"},{"name":"Shuxin Wang"},{"name":"Wanting Du"},{"name":"Mingqing Chen"}],"abstract":"Abstract Background Increasing attention is being paid to the environmental and health impacts of nanoplastics (NPs) pollution. Exposure to nanoplastics (NPs) with different charges and functional groups may have different adverse effects after ingestion by organisms, yet the potential ramifications on mammalian blood glucose levels, and the risk of diabetes remain unexplored. Results Mice were exposed to PS-NPs/COOH/NH2 at a dose of 5 mg/kg/day for nine weeks, either alone or in a T2DM model. The findings demonstrated that exposure to PS-NPs modified by different functional groups caused a notable rise in fasting blood glucose (FBG) levels, glucose intolerance, and insulin resistance in a mouse model of T2DM. Exposure to PS-NPs-NH2 alone can also lead the above effects to a certain degree. PS-NPs exposure could induce glycogen accumulation and hepatocellular edema, as well as injury to the pancreas. Comparing the effect of different functional groups or charges on T2DM, the PS-NPs-NH2 group exhibited the most significant FBG elevation, glycogen accumulation, and insulin resistance. The phosphorylation of AKT and FoxO1 was found to be inhibited by PS-NPs exposure. Treatment with SC79, the selective AKT activator was shown to effectively rescue this process and attenuate T2DM like lesions. Conclusions Exposure to PS-NPs with different functional groups (charges) induced T2DM-like lesions. Amino-modified PS-NPs cause more serious T2DM-like lesions than pristine PS-NPs or carboxyl functionalized PS-NPs. The underlying mechanisms involved the inhibition of P-AKT/P-FoxO1. This study highlights the potential risk of NPs pollution on T2DM, and provides a new perspective for evaluating the impact of plastics aging.","source":"DOAJ","year":2024,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-024-00582-w","url":"https://doi.org/10.1186/s12989-024-00582-w","is_open_access":true,"published_at":"","score":68},{"id":"doaj_10.1186/s12989-023-00555-5","title":"Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life","authors":[{"name":"Caroline Carlé"},{"name":"Delphine Boucher"},{"name":"Luisa Morelli"},{"name":"Camille Larue"},{"name":"Ekaterina Ovtchinnikova"},{"name":"Louise Battut"},{"name":"Kawthar Boumessid"},{"name":"Melvin Airaud"},{"name":"Muriel Quaranta-Nicaise"},{"name":"Jean-Luc Ravanat"},{"name":"Gilles Dietrich"},{"name":"Sandrine Menard"},{"name":"Gérard Eberl"},{"name":"Nicolas Barnich"},{"name":"Emmanuel Mas"},{"name":"Marie Carriere"},{"name":"Ziad Al Nabhani"},{"name":"Frédérick Barreau"}],"abstract":"Abstract Background Perinatal exposure to titanium dioxide (TiO2), as a foodborne particle, may influence the intestinal barrier function and the susceptibility to develop inflammatory bowel diseases (IBD) later in life. Here, we investigate the impact of perinatal foodborne TiO2 exposure on the intestinal mucosal function and the susceptibility to develop IBD-associated colitis. Pregnant and lactating mother mice were exposed to TiO2 until pups weaning and the gut microbiota and intestinal barrier function of their offspring was assessed at day 30 post-birth (weaning) and at adult age (50 days). Epigenetic marks was studied by DNA methylation profile measuring the level of 5-methyl-2′-deoxycytosine (5-Me-dC) in DNA from colic epithelial cells. The susceptibility to develop IBD has been monitored using dextran-sulfate sodium (DSS)-induced colitis model. Germ-free mice were used to define whether microbial transfer influence the mucosal homeostasis and subsequent exacerbation of DSS-induced colitis. Results In pregnant and lactating mice, foodborne TiO2 was able to translocate across the host barriers including gut, placenta and mammary gland to reach embryos and pups, respectively. This passage modified the chemical element composition of foetus, and spleen and liver of mothers and their offspring. We showed that perinatal exposure to TiO2 early in life alters the gut microbiota composition, increases the intestinal epithelial permeability and enhances the colonic cytokines and myosin light chain kinase expression. Moreover, perinatal exposure to TiO2 also modifies the abilities of intestinal stem cells to survive, grow and generate a functional epithelium. Maternal TiO2 exposure increases the susceptibility of offspring mice to develop severe DSS-induced colitis later in life. Finally, transfer of TiO2-induced microbiota dysbiosis to pregnant germ-free mice affects the homeostasis of the intestinal mucosal barrier early in life and confers an increased susceptibility to develop colitis in adult offspring. Conclusions Our findings indicate that foodborne TiO2 consumption during the perinatal period has negative long-lasting consequences on the development of the intestinal mucosal barrier toward higher colitis susceptibility. This demonstrates to which extent environmental factors influence the microbial-host interplay and impact the long-term mucosal homeostasis.","source":"DOAJ","year":2023,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-023-00555-5","url":"https://doi.org/10.1186/s12989-023-00555-5","is_open_access":true,"published_at":"","score":67},{"id":"ss_434d4d57c2ef3c194e79649d95ecf95834407938","title":"Industrial Hygiene and Safety","authors":[{"name":"S. Sowmiya"}],"abstract":"Industrial safety and hygiene is an area concerning the safety, health and welfare of people engaged in work or employment in industries and companies. It is to forecast, to assess, to identify and to control hazards. The unsafe working conditions affect worker’s health and productivity. The industrial safety and hygiene improve people life, improve their work condition and increase productivity where they work. The care for each other is the right to do protecting every family’s health, safety and environment. The workers have to be protected from the chemical, biological, physical, ergonomic and psychosocial hazards. This study provides the necessary information and facts about industrial hygiene and safety.","source":"Semantic Scholar","year":2023,"language":"en","subjects":null,"doi":"10.21839/lsdjmr.2023.v2.36","url":"https://www.semanticscholar.org/paper/434d4d57c2ef3c194e79649d95ecf95834407938","pdf_url":"https://www.lsdjmr.com/index.php/journal/article/download/36/59","is_open_access":true,"published_at":"","score":67},{"id":"ss_369d1dc401b0868e4d488446e31a26dee0ef2a8a","title":"The Implementation of Sanitary Personal Hygiene and the Amount of Liquid and Solid Waste on the Production of North Cibuntu Tofu Factory Sumedang","authors":[{"name":"Gita Arisara"},{"name":"Tetin Nur Andriani"},{"name":"Nabilah Nabilah"},{"name":"Siti Nurhasanah"},{"name":"Yulia Siti Fathonah"}],"abstract":"Hygiene is a public health action that specifically covers all efforts to protect, maintain and enhance the degree of physical and mental health, both for the public and for individuals with the aim of the basics of continuing a healthy life and enhancing welfare and energy. Sanitation is a public health effort that focuses on monitoring various environmental factors that can affect human health status. Tofu industrial waste water is one type of industry that disposes of its liquid and solid waste processing either directly or indirectly into water bodies, where in the tofu production process a lot of water is needed for the production process. The purpose of this study was to increase knowledge and change the behavior of employees at the Cibuntu tofu factory in order to understand personal hygiene and to find out how the process of processing liquid and solid waste from the production of the Cibuntu tofu factory in North Sumedang District. This study used descriptive qualitative method. Data collection techniques were carried out by interviews, observation, and documentation with informants. Results: Based on the observations of 25 employees, 19 (84%) of the tofu factory employees did not apply personal hygiene at work, most did not use company standard clothing, even 4 employees did not wear clothes, 16 employees (70%) did not use masks and did not use gloves, even the soy bean filter was not washed, while the waste treatment was carried out according to a predetermined WWTP procedure. There is a filtering process in wastewater treatment and a large tub is available for the filtering process so that the wastewater discharged into the river is quite safe. The conclusions from this study need to be improved and reapplied regarding personal hygiene for employees of the Cibuntu tofu factory.","source":"Semantic Scholar","year":2023,"language":"en","subjects":null,"doi":"10.35568/abdimas.v6i2.3110","url":"https://www.semanticscholar.org/paper/369d1dc401b0868e4d488446e31a26dee0ef2a8a","is_open_access":true,"published_at":"","score":67},{"id":"doaj_10.1186/s12989-022-00471-0","title":"Exposure to lead-free frangible firing emissions containing copper and ultrafine particulates leads to increased oxidative stress in firing range instructors","authors":[{"name":"Ryan J. McNeilly"},{"name":"Jennifer A. Schwanekamp"},{"name":"Logan S. Hyder"},{"name":"John P. Hatch"},{"name":"Brett T. Edwards"},{"name":"Jacob A. Kirsh"},{"name":"Jerimiah M. Jackson"},{"name":"Thomas Jaworek"},{"name":"Mark M. Methner"},{"name":"Christin M. Duran"}],"abstract":"Abstract Background Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms including chest tightness, respiratory irritation, and metallic taste. These symptoms have been reported despite measurements determining that instructor exposure does not exceed established occupational exposure limits (OELs). The disconnect between reported symptoms and exposure limits may be due to a limited understanding of LFF firing byproducts and subsequent health effects. A comprehensive characterization of exposure to instructors was completed, including ventilation system evaluation, personal monitoring, symptom tracking, and biomarker analysis, at both a partially enclosed and fully enclosed range. Results Instructors reported symptoms more frequently after M4 rifle classes compared to classes firing only the M9 pistol. Ventilation measurements demonstrated that airflow velocities at the firing line were highly variable and often outside established standards at both ranges. Personal breathing zone air monitoring showed exposure to carbon monoxide, ultrafine particulate, and metals. In general, exposure to instructors was higher at the partially enclosed range compared to the fully enclosed range. Copper measured in the breathing zone of instructors, on rare occasions, approached OELs for copper fume (0.1 mg/m3). Peak carbon monoxide concentrations were 4–5 times higher at the partially enclosed range compared to the enclosed range and occasionally exceeded the ceiling limit (125 ppm). Biological monitoring showed that lung function was maintained in instructors despite respiratory symptoms. However, urinary oxidative stress biomarkers and urinary copper measurements were increased in instructors compared to control groups. Conclusions Consistent with prior work, this study demonstrates that symptoms still occurred despite exposures below OELs. Routine monitoring of symptoms, urinary metals, and oxidative stress biomarkers can help identify instructors who are particularly affected by exposures. These results can assist in guiding protective measures to reduce exposure and protect instructor health. Further, a longitudinal study is needed to determine the long-term health consequences of LFF firing emissions exposure.","source":"DOAJ","year":2022,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-022-00471-0","url":"https://doi.org/10.1186/s12989-022-00471-0","is_open_access":true,"published_at":"","score":66},{"id":"ss_45e22673a175d9697d5174323af1f13b1d86d4f0","title":"The Intrinsic and Extrinsic Work Values according to Characteristics of Dental Hygiene Students","authors":[{"name":"B. Park"},{"name":"Mi-Suk Yoon"}],"abstract":"This study identifies the differences in intrinsic and extrinsic work values when considering general characteristics. Totally, 194 dental hygiene students were surveyed from February to May 2022. We examined the importance of each factor pertaining to general characteristics and intrinsic and extrinsic work values. Frequency analysis, descriptive statistics, t-test, and one-way ANOVA were performed. Our results revealed that the most important factors were aptitudes and interests for intrinsic work values, and work atmosphere was the leading factor in extrinsic work values. The importance of extrinsic work values was relatively higher than intrinsic work values. Subjects with part-time dental experience recognized the future prospects of their profession as critical, whereas those awaiting employment in dentistry recognized the possibility of demonstrating the competency of a dental hygienist as important. Moreover, crucial factors recognized by female students were welfare benefits for rest support and safety of employment; differences were also obtained in extrinsic work values when dentistry was considered as a future career. Based on our study results, we propose that dental clinics looking to hire new dental hygienists need to consider and give importance to the work values recognized by prospective dental hygienists and make efforts to create a working environment that reflects their needs.","source":"Semantic Scholar","year":2022,"language":"en","subjects":null,"doi":"10.5762/kais.2022.23.12.125","url":"https://www.semanticscholar.org/paper/45e22673a175d9697d5174323af1f13b1d86d4f0","pdf_url":"https://doi.org/10.5762/kais.2022.23.12.125","is_open_access":true,"published_at":"","score":66},{"id":"doaj_10.20473/ijosh.v10i3.2021.309-315","title":"Psychosocial Risk Factors on Mining Workers Processing Copper and Gold Minerals during Covid-19 Pandemic","authors":[{"name":"Khaerani Suci Lestari"},{"name":"Aditya Fadilah Muhamad"},{"name":"Arif Susanto"},{"name":"Edi Karyono Putro"},{"name":"John Charles Wilmot"},{"name":"Yenni Miranda Savira"},{"name":"Aprilia Listiarini"},{"name":"Donny Zulfakar"},{"name":"Stevan Deby Anbiya Muhamad Sunarno"}],"abstract":"Introduction: In the era of the Covid-19 pandemic, psychosocial issues as part of health and safety have become a popular mental health issue, particularly among gold and copper miners. This situation has led some companies to fire their unskilled and unproductive workers to minimize the production costs. However, there is no specific regulation for the workers that could be a barrier of this unpredicted situation. This condition mostly becomes a negative stressor for the workers at the jobsite. At some point, it develops to a critical health and safety condition known as risky and unhealthy behavior that brings to fatality. The aim of this research is to analyze the psychosocial risk factors that adversely affect the psychology of copper and gold mining workers during the pandemic. Method: This is a cross-sectional study with COPSOQ III, used to identify factors contributing to workers’ psychology, while Dolan \u0026 Arsenault’s questionnaire was used to analyze stress symptoms, with a Cronbach α value of 0.83-0.84. Results: Multivariate tests were conducted on the variables of work experience, body mass index, marital status, emotional demands, vertical trust, and organizational justice. Significance values were obtained for the variables of work experience (0.590 body mass index (0.517), marital status (0.122), emotional demands (0.187), vertical trust (0.000), and organizational justice (0.119). Of the six variables, only vertical trusthad a significant value. Conclusion: Psychological risk factors on copper and gold mining workers during the pandemic are only influenced by a vertical trust.\n\n\nKeywords: COPSOQ III, leadership, pandemic, psychosocial, vertical trust","source":"DOAJ","year":2021,"language":"","subjects":["Industrial safety. Industrial accident prevention","Industrial hygiene. Industrial welfare"],"doi":"10.20473/ijosh.v10i3.2021.309-315","url":"https://e-journal.unair.ac.id/IJOSH/article/view/26075","is_open_access":true,"published_at":"","score":65},{"id":"doaj_10.1186/s12989-020-00357-z","title":"Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice","authors":[{"name":"Christine Coméra"},{"name":"Christel Cartier"},{"name":"Eric Gaultier"},{"name":"Olivier Catrice"},{"name":"Quentin Panouille"},{"name":"Sarah El Hamdi"},{"name":"Kristof Tirez"},{"name":"Inge Nelissen"},{"name":"Vassilia Théodorou"},{"name":"Eric Houdeau"}],"abstract":"Abstract Background Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to induce and promote preneoplastic lesions in the rodent gut. Characterization of intestinal TiO2 uptake is essential for assessing the health risk in humans. We studied in vivo the gut absorption kinetics of TiO2 in fasted mice orally given a single dose (40 mg/kg) to assess the ability of intestinal apical surfaces to absorb particles when available without entrapment in the bolus. The epithelial translocation pathways were also identified ex vivo using intestinal loops in anesthetized mice. Results The absorption of TiO2 particles was analyzed in gut tissues by laser-reflective confocal microscopy and ICP-MS at 4 and 8 h following oral administration. A bimodal pattern was detected in the small intestine: TiO2 absorption peaked at 4 h in jejunal and ileal villi before returning to basal levels at 8 h, while being undetectable at 4 h but significantly present at 8 h in the jejunal Peyer’s patches (PP). Lower absorption occurred in the colon, while TiO2 particles were clearly detectable by confocal microscopy in the blood at 4 and 8 h after treatment. Ex vivo, jejunal loops were exposed to the food additive in the presence and absence of pharmacological inhibitors of paracellular tight junction (TJ) permeability or of transcellular (endocytic) passage. Thirty minutes after E171 addition, TiO2 absorption by the jejunal villi was decreased by 66% (p \u003c 0.001 vs. control) in the presence of the paracellular permeability blocker triaminopyrimidine; the other inhibitors had no significant effect. Substantial absorption through a goblet cell (GC)-associated pathway, insensitive to TJ blockade, was also detected. Conclusions After a single E171 dose in mice, early intestinal uptake of TiO2 particles mainly occurred through the villi of the small intestine, which, in contrast to the PP, represent the main absorption surface in the small intestine. A GC-associated passage and passive diffusion through paracellular TJ spaces between enterocytes appeared to be major absorption routes for transepithelial uptake of dietary TiO2.","source":"DOAJ","year":2020,"language":"","subjects":["Toxicology. Poisons","Industrial hygiene. Industrial welfare"],"doi":"10.1186/s12989-020-00357-z","url":"http://link.springer.com/article/10.1186/s12989-020-00357-z","is_open_access":true,"published_at":"","score":64},{"id":"doaj_10.20473/ijosh.v9i3.2020.239-247","title":"Respondent’s Characteristic and Noise Intensity as Predicting Factors of Noise Induced Hearing Loss","authors":[{"name":"Decy Situngkir"},{"name":"Ira Marti Ayu"},{"name":"Laosma Sipahutar"}],"abstract":"Introduction: Sensorineural hearing loss caused by loud noise exposure for a long time is known as the risk ofexperiencing Noise-Induced Hearing Loss. PT. Multi Karya Asia Pacific Raya (PT. MKAPR) is a company that provides products and services to the oil and gas industry in Indonesia. Based on its medical check-up, workshop workers at PT MKAPR have the risk of experiencing Noise-Induced Hearing Loss. The Lodan-9 Workshop area was known to have different noise levels, 88-91 dB in the fabrication, pump and engineering areas, and 90-102 dB in the function test area. The purpose of this study was to identify predicting factors of Noise-Induced Hearing Loss at PT. MKAPR. Method: This study used a case-control design. The population in this study were 26 cases and 48 control. Sample size in this study consisted of 26 cases and 26 control. We used a purposive technique sampling. Data were collected through questionnaire, and then were analyzed by using Chi-Square Test. Result: There were association between noise intensity (P-value: 0.035 OR: 4.714; 95% CI: 1.266-17.561), and work period (P-value: 0.029; OR 5.622; 95% CI: 1.342-23.55) with the incidence of Noise-Induced Hearing Loss. Meanwhile age of workers (P-value: 1; OR: 1.547; 95% CI: 0.336-2.976) and smoking habits (P-value: 0.465; OR: 0.435; 95% CI: 0.096-1.168) have no relationship with the incidence of Noise-Induced Hearing Loss. Conclusion: Noise intensity and work period were predictors of Noise-Induced Hearing Loss on PT.MKAPR’ workers. The longer the workers work in high noise intensity area, the more they are at risk of experiencing Noise-Induced Hearing Loss.\n\n\nKeywords: ear, noise-induced hearing loss, noise, noise intensity","source":"DOAJ","year":2020,"language":"","subjects":["Industrial safety. Industrial accident prevention","Industrial hygiene. Industrial welfare"],"doi":"10.20473/ijosh.v9i3.2020.239-247","url":"https://e-journal.unair.ac.id/IJOSH/article/view/16934","is_open_access":true,"published_at":"","score":64},{"id":"ss_b41962664b5cbae9eb4fefa6b45800ea70243197","title":"INDUSTRIAL ENTERPRISES AND HEALTH RISK CATEGORIES","authors":[{"name":"D. V. Goryaev"},{"name":"I. Tikhonova"},{"name":"D. Kiryanov"}],"abstract":"In order to ensure the sanitary and epidemiological welfare of the population in the Russian Federation, measures are being taken to improve control and supervisory activities through the introduction of a risk-based approach to the organization of control and surveillance activities. At the base of the risk-based supervision, there is a differentiated approach to control and supervisory activities concentrating efforts on enterprises that pose Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeingeptable health risks. The potential danger of the facilities subject to federal state sanitary and epidemiological supervision in the Krasnoyarsk Territory was assessed with regard to the health risk criteria. In the Krasnoyarsk Territory, with taking into account types of economic activity, 40.83% of the industrial enterprises fall under the category of those involving extremely high, high and significant public health risk. 1.6% of the economic entities pose an extremely high health risk in the Krasnoyarsk Territory as a whole and, with bearing in mind their activities, the percentage of such entities is slightly lower (1.48%). In terms of industrial enterprises’ activity, compared to other economic entities, the percentage of the enterprises posing extremely high risk is the highest and amounts to 4.37%. Such a prevailing ratio is typical for high-risk enterprises - 7.05%; 6.7% and 12.65% respectively, with approximately the same ratio of the enterprises posing a significant risk - 23.14%; 22.79% and 23.81% respectively. When assessing the total risk created by the economic entities of the Krasnoyarsk Territory with the consideration of their types of activity, the contribution of the enterprises posing extremely high risk was found to be 80.11%, and when considering risks related to the activities of industrial enterprises, the share of such facilities increases to 92.6%. In the Krasnoyarsk Territory, industrial enterprises are the main factor affecting the environmental quality, and therefore it becomes important to actively use the social and hygienic monitoring system as part of state control over the activities of industrial enterprises, the system that provides data on environmental factors and health status to be applied by the system of environmental management and public health.","source":"Semantic Scholar","year":2019,"language":"en","subjects":["Business"],"doi":"10.18821/0016-9900-2017-96-12-1155-1158","url":"https://www.semanticscholar.org/paper/b41962664b5cbae9eb4fefa6b45800ea70243197","pdf_url":"https://doi.org/10.18821/0016-9900-2017-96-12-1155-1158","is_open_access":true,"citations":6,"published_at":"","score":63.18},{"id":"ss_67b0cce94d19c63f62a667397cf00d61d2b29bf7","title":"G650 A nineteenth century medical officer of health and child welfare","authors":[{"name":"P. Brennan"}],"abstract":"In 1873 a Medical Officer of Health (MOH) was first appointed in a rapidly enlarging industrial northern city. This was 3 years after the 1870 Education Act which introduced 5 years primary education for all children, usually between the ages of 5 and 10 years. Once children were gathered together in the classroom, the condition of the poor, their clothes and hygiene, and above all, their health was realised. The impact of the MOH on local children’s health was studied using local sources including Council and Health Committee minutes, MOH annual reports, school records and newspaper articles. The MOH had a wide ranging remit from sewage disposal to the health of all children. He was guided by laws such as the Vaccination Acts and the 1889 Children Act, by a national network of MOHs and in addition he introduced his own local procedures. He oversaw general measures to set up the infrastructure of a modern city, such as a clean water supply, a sewerage system, and monitored air pollution and adulteration of food and took legal action to enforce compliance with guidelines. All this improved the welfare of the population, including children. Illnesses and deaths of children and infants received particular attention when MOH undertook a huge audit by introducing a local notification system for illness. This was limited in quality as diagnoses were not always accurate. Nevertheless, they were sufficient to focus treatment and preventative measures for common infectious diseases such as measles, scarlet fever, diphtheria and tuberculosis. This resulted in amngst other things, contact tracing and vaccinations for smallpox, disinfection centres for household goods and advice to school staff. The MOH also monitored and influenced services for specific groups of children, such as the deaf, blind and migratory children in canal boat families. This paper will illustrate the work of the MOH in detail, including the raw data, interpretation and measures put in place to improve the health and welfare of children in this industrial city.","source":"Semantic Scholar","year":2019,"language":"en","subjects":["Medicine"],"doi":"10.1136/archdischild-2019-rcpch.629","url":"https://www.semanticscholar.org/paper/67b0cce94d19c63f62a667397cf00d61d2b29bf7","is_open_access":true,"published_at":"","score":63},{"id":"doaj_10.20473/ijosh.v7i1.2018.112-121","title":"PERBEDAAN KADAR PM2,5 DI TEMPAT PEMBAKARAN BATU BATA DAN KEJADIAN SINDROMA MATA KERING","authors":[{"name":"Nur Rohmawati"},{"name":"Retno Andriyani"}],"abstract":"Brick cumbustion in Kaloran Village uses firewood and corncob as main fuel. Combustion using firewood and corncobs in  burning bricks produce PM2.5 pollutants that can cause health problem including the eyes. Dry eye is a multifactorial disease of ocular surface in symptoms that include discomfort, visual disturbance and tear film instability with potential damage to the ocular surface. This study aims to describe PM2.5 levels in brick combustion and dry eye syndrome events in brick workers in Kaloran Village Ngronggot Nganjuk District in 2017. This research was an observational study with cross sectional design, conducted in May 2017, Using questionnaires, interviews and observations with a large sample of 42 respondents. The PM2.5 measurements use the Haz-Dust EPAM 5000 model for 30 minutes, which is performed three times a day at each point of location. Data collection on the incidence of dry eye syndrome was diagnosed using an OSDI questionnaire. All measurements of PM2.5 exceed the ambient air quality standard of government regulation number 41 of 1999 of (0.065 mg/m3) and There are three measurement result of PM2.5 that exceed the Threshold Limit No 13 of 2011 about Threshold Value of Physical Factors and Chemical Factors in the Work Environment. There are 71.6% workers experience dry eye syndrome. In the results of this study, PM2.5 levels are in place. The advantages and disadvantages of some places that exceed the Threshold Limit and there are workers who experience dry eye syndrome.\n\n Keywords: burning bricks, dry eye syndrome, level of  PM2,5","source":"DOAJ","year":2018,"language":"","subjects":["Industrial safety. Industrial accident prevention","Industrial hygiene. Industrial welfare"],"doi":"10.20473/ijosh.v7i1.2018.112-121","url":"https://e-journal.unair.ac.id/IJOSH/article/view/5233","is_open_access":true,"published_at":"","score":62}],"total":1515828,"page":1,"page_size":20,"sources":["CrossRef","DOAJ","Semantic Scholar"],"query":"Industrial hygiene. Industrial welfare"}