{"results":[{"id":"ss_3946c90c02822ba0b2a96031fa9b1f59089491a2","title":"Database resources of the national center for biotechnology information","authors":[{"name":"E. Sayers"},{"name":"Evan E. Bolton"},{"name":"J. R. Brister"},{"name":"Kathi Canese"},{"name":"Jessica Chan"},{"name":"Donald C. Comeau"},{"name":"Ryan Connor"},{"name":"Kathryn Funk"},{"name":"Christopher Kelly"},{"name":"Sunghwan Kim"},{"name":"T. Madej"},{"name":"Aron Marchler-Bauer"},{"name":"C. Lanczycki"},{"name":"S. Lathrop"},{"name":"Zhiyong Lu"},{"name":"F. Thibaud-Nissen"},{"name":"Terence D. Murphy"},{"name":"Lon Phan"},{"name":"Yuri Skripchenko"},{"name":"Tony Tse"},{"name":"Jiyao Wang"},{"name":"Rebecca J Williams"},{"name":"B. Trawick"},{"name":"K. Pruitt"},{"name":"S. Sherry"}],"abstract":"The National Center for Biotechnology Information (NCBI) produces a variety of online information resources for biology, including the GenBank® nucleic acid sequence database and the PubMed® database of citations and abstracts published in life science journals. NCBI provides search and retrieval operations for most of these data from 35 distinct databases. The E-utilities serve as the programming interface for the most of these databases. Resources receiving significant updates in the past year include PubMed, PMC, Bookshelf, RefSeq, SRA, Virus, dbSNP, dbVar, ClinicalTrials.gov, MMDB, iCn3D and PubChem. These resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2021,"language":"en","subjects":["Computer Science","Medicine"],"doi":"10.1093/nar/gkab1112","url":"https://www.semanticscholar.org/paper/3946c90c02822ba0b2a96031fa9b1f59089491a2","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D20/42058080/gkab1112.pdf","is_open_access":true,"citations":1442,"published_at":"","score":95},{"id":"ss_960e7494ef4ec5964407488080f249104cd218f0","title":"Database resources of the National Center for Biotechnology Information","authors":[{"name":"E. Sayers"},{"name":"J. Beck"},{"name":"Evan E. Bolton"},{"name":"Devon Bourexis"},{"name":"J. R. Brister"},{"name":"Kathi Canese"},{"name":"Donald C. Comeau"},{"name":"Kathryn Funk"},{"name":"Sunghwan Kim"},{"name":"W. Klimke"},{"name":"Aron Marchler-Bauer"},{"name":"M. Landrum"},{"name":"S. Lathrop"},{"name":"Zhiyong Lu"},{"name":"Thomas L. Madden"},{"name":"N. O'Leary"},{"name":"Lon Phan"},{"name":"S. Rangwala"},{"name":"Valerie A. Schneider"},{"name":"Yuri Skripchenko"},{"name":"Jiyao Wang"},{"name":"Jian Ye"},{"name":"B. Trawick"},{"name":"K. Pruitt"},{"name":"S. Sherry"}],"abstract":"The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed® database of citations and abstracts published in life science journals. The Entrez system provides search and retrieval operations for most of these data from 34 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Custom implementations of the BLAST program provide sequence-based searching of many specialized datasets. New resources released in the past year include a new PubMed interface and NCBI datasets. Additional resources that were updated in the past year include PMC, Bookshelf, Genome Data Viewer, SRA, ClinVar, dbSNP, dbVar, Pathogen Detection, BLAST, Primer-BLAST, IgBLAST, iCn3D and PubChem. All of these resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2020,"language":"en","subjects":["Computer Science","Medicine"],"doi":"10.1093/nar/gkaa892","url":"https://www.semanticscholar.org/paper/960e7494ef4ec5964407488080f249104cd218f0","pdf_url":"https://academic.oup.com/nar/article-pdf/49/D1/D10/35364804/gkaa892.pdf","is_open_access":true,"citations":1248,"published_at":"","score":94},{"id":"ss_e13a691b1ae74edcfad584b548f8fd127d4b6033","title":"National Center for Biotechnology Information","authors":null,"abstract":"","source":"Semantic Scholar","year":2019,"language":"en","subjects":null,"doi":"10.1007/978-3-662-48986-4_301184","url":"https://www.semanticscholar.org/paper/e13a691b1ae74edcfad584b548f8fd127d4b6033","is_open_access":true,"citations":2350,"published_at":"","score":93},{"id":"ss_da692ee969d9c33986196372c3f7cb87fa6b6f8f","title":"Database resources of the National Center for Biotechnology Information","authors":[{"name":"Richa Tanya Jeff Dennis A Colleen Evan Devon J Rodney St Agarwala Barrett Beck Benson Bollin Bolton Bourexi"},{"name":"R. Agarwala"},{"name":"Tanya Barrett"},{"name":"J. Beck"},{"name":"Dennis A. Benson"},{"name":"Colleen J. Bollin"},{"name":"Evan E. Bolton"},{"name":"Devon Bourexis"},{"name":"J. R. Brister"},{"name":"S. Bryant"},{"name":"Kathi Canese"},{"name":"Mark Cavanaugh"},{"name":"Chad Charowhas"},{"name":"Karen Clark"},{"name":"I. Dondoshansky"},{"name":"M. Feolo"},{"name":"Lawrence Fitzpatrick"},{"name":"Kathryn Funk"},{"name":"Lewis Y. Geer"},{"name":"V. Gorelenkov"},{"name":"Alan Graeff"},{"name":"W. Hlavina"},{"name":"Brad Holmes"},{"name":"Mark Johnson"},{"name":"B. Kattman"},{"name":"Viatcheslav Khotomlianski"},{"name":"Avi Kimchi"},{"name":"Michael Kimelman"},{"name":"Masato Kimura"},{"name":"P. Kitts"},{"name":"W. Klimke"},{"name":"A. Kotliarov"},{"name":"S. Krasnov"},{"name":"A. Kuznetsov"},{"name":"M. Landrum"},{"name":"D. Landsman"},{"name":"S. Lathrop"},{"name":"Jennifer M. Lee"},{"name":"Carl Leubsdorf"},{"name":"Zhiyong Lu"},{"name":"Thomas L. Madden"},{"name":"Aron Marchler-Bauer"},{"name":"Adriana Malheiro"},{"name":"Peter A. Meric"},{"name":"I. Karsch-Mizrachi"},{"name":"Anatoly Mnev"},{"name":"Terence D. Murphy"},{"name":"R. Orris"},{"name":"J. Ostell"},{"name":"Christopher O'Sullivan"},{"name":"Vasuki Palanigobu"},{"name":"A. Panchenko"},{"name":"Lon Phan"},{"name":"Borys Pierov"},{"name":"K. Pruitt"},{"name":"K. Rodarmer"},{"name":"E. Sayers"},{"name":"Valerie A. Schneider"},{"name":"C. Schoch"},{"name":"G. Schuler"},{"name":"S. Sherry"},{"name":"Karanjit Siyan"},{"name":"Alexandra Soboleva"},{"name":"Vladimir Soussov"},{"name":"G. Starchenko"},{"name":"T. Tatusova"},{"name":"F. Thibaud-Nissen"},{"name":"K. Todorov"},{"name":"B. Trawick"},{"name":"D. Vakatov"},{"name":"Minghong Ward"},{"name":"E. Yaschenko"},{"name":"A. Zasypkin"},{"name":"Kerry Zbicz"}],"abstract":"Abstract The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. The Entrez system provides search and retrieval operations for most of these data from 39 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. New resources released in the past year include PubMed Data Management, RefSeq Functional Elements, genome data download, variation services API, Magic-BLAST, QuickBLASTp, and Identical Protein Groups. Resources that were updated in the past year include the genome data viewer, a human genome resources page, Gene, virus variation, OSIRIS, and PubChem. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2017,"language":"en","subjects":["Medicine","Computer Science"],"doi":"10.1093/nar/gkx1095","url":"https://www.semanticscholar.org/paper/da692ee969d9c33986196372c3f7cb87fa6b6f8f","pdf_url":"https://academic.oup.com/nar/article-pdf/46/D1/D8/23162308/gkx1095.pdf","is_open_access":true,"citations":5770,"published_at":"","score":91},{"id":"ss_3f376a9b2d659e52c98d911a1fb3aa3a834f66e5","title":"Database resources of the National Center for Biotechnology Information","authors":[{"name":"David L. Wheeler"},{"name":"Tanya Barrett"},{"name":"Dennis A. Benson"},{"name":"Stephen H. Bryant"},{"name":"Kathi Canese"},{"name":"V. Chetvernin"},{"name":"Deanna M. Church"},{"name":"Michael DiCuccio"},{"name":"Ron Edgar"},{"name":"S. Federhen"},{"name":"Lewis Y. Geer"},{"name":"Wolfgang Helmberg"},{"name":"Yuri Kapustin"},{"name":"D. L. Kenton"},{"name":"Oleg Khovayko"},{"name":"D. Lipman"},{"name":"Thomas L. Madden"},{"name":"D. Maglott"},{"name":"J. Ostell"},{"name":"K. Pruitt"},{"name":"Gregory D. Schuler"},{"name":"L. M. Schriml"},{"name":"E. Sequeira"},{"name":"Stephen T. Sherry"},{"name":"K. Sirotkin"},{"name":"A. Souvorov"},{"name":"G. Starchenko"},{"name":"Tugba Onal Suzek"},{"name":"R. Tatusov"},{"name":"T. Tatusova"},{"name":"Lukas Wagner"},{"name":"E. Yaschenko"}],"abstract":"The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2014,"language":"en","subjects":["Computer Science","Medicine"],"doi":"10.1093/nar/gku1130","url":"https://www.semanticscholar.org/paper/3f376a9b2d659e52c98d911a1fb3aa3a834f66e5","pdf_url":"https://academic.oup.com/nar/article-pdf/43/D1/D6/7320708/gku1130.pdf","is_open_access":true,"citations":2711,"published_at":"","score":88},{"id":"ss_6e3d8390a0129602e4680baeb9a87ff2b89b7db4","title":"Biodiesel Production by Microalgal Biotechnology","authors":[{"name":"Guanhua Huang"},{"name":"Feng Chen"},{"name":"D. Wei"},{"name":"Xuewu Zhang"},{"name":"Gu Chen"}],"abstract":"Biodiesel has received much attention in recent years. Although numerous reports are available on the production of biodiesel from vegetable oils of terraneous oil-plants, such as soybean, sunflower and palm oils, the production of biodiesel from microalgae is a newly emerging field. Microalgal biotechnology appears to possess high potential for biodiesel production because a significant increase in lipid content of microalgae is now possible through heterotrophic cultivation and genetic engineering approaches. This paper provides an overview of the technologies in the production of biodiesel from microalgae, including the various modes of cultivation for the production of oil-rich microalgal biomass, as well as the subsequent downstream processing for biodiesel production. The advances and prospects of using microalgal biotechnology for biodiesel production are discussed.","source":"Semantic Scholar","year":2018,"language":"en","subjects":["Biology"],"doi":"10.1016/J.APENERGY.2009.06.016","url":"https://www.semanticscholar.org/paper/6e3d8390a0129602e4680baeb9a87ff2b89b7db4","is_open_access":true,"citations":785,"published_at":"","score":85.55},{"id":"ss_db5f84455643fba576ef79f59a3141d25c428ad8","title":"Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine","authors":[{"name":"D. Lombardo"},{"name":"M. Kiselev"},{"name":"M. T. Caccamo"}],"abstract":"The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.","source":"Semantic Scholar","year":2019,"language":"en","subjects":["Materials Science"],"doi":"10.1155/2019/3702518","url":"https://www.semanticscholar.org/paper/db5f84455643fba576ef79f59a3141d25c428ad8","pdf_url":"http://downloads.hindawi.com/journals/jnm/2019/3702518.pdf","is_open_access":true,"citations":672,"published_at":"","score":83.16},{"id":"ss_ea35cd7fd2c46f86232f21ef73239f34f2d180a6","title":"Database resources of the National Center for Biotechnology Information.","authors":[{"name":"E. Sayers"},{"name":"J. Beck"},{"name":"J. R. Brister"},{"name":"Evan E. Bolton"},{"name":"Kathi Canese"},{"name":"Donald C. Comeau"},{"name":"Kathryn Funk"},{"name":"A. Ketter"},{"name":"Sunghwan Kim"},{"name":"Avi Kimchi"},{"name":"P. Kitts"},{"name":"A. Kuznetsov"},{"name":"S. Lathrop"},{"name":"Zhiyong Lu"},{"name":"Kelly M. McGarvey"},{"name":"Thomas L. Madden"},{"name":"Terence D. Murphy"},{"name":"N. O'Leary"},{"name":"Lon Phan"},{"name":"Valerie A. Schneider"},{"name":"F. Thibaud-Nissen"},{"name":"B. Trawick"},{"name":"K. Pruitt"},{"name":"J. Ostell"}],"abstract":"The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts published in life science journals. The Entrez system provides search and retrieval operations for most of these data from 35 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Custom implementations of the BLAST program provide sequence-based searching of many specialized datasets. New resources released in the past year include a new PubMed interface, a sequence database search and a gene orthologs page. Additional resources that were updated in the past year include PMC, Bookshelf, My Bibliography, Assembly, RefSeq, viral genomes, the prokaryotic genome annotation pipeline, Genome Workbench, dbSNP, BLAST, Primer-BLAST, IgBLAST and PubChem. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2019,"language":"en","subjects":["Medicine"],"doi":"10.1093/nar/gkz899","url":"https://www.semanticscholar.org/paper/ea35cd7fd2c46f86232f21ef73239f34f2d180a6","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D9/31697986/gkz899.pdf","is_open_access":true,"citations":645,"published_at":"","score":82.35},{"id":"ss_c3cc6d656df9ac30dbc6ce845ed8443a3c6f1e10","title":"The ecology and biotechnology of sulphate-reducing bacteria","authors":[{"name":"G. Muyzer"},{"name":"A. Stams"}],"abstract":"","source":"Semantic Scholar","year":2008,"language":"en","subjects":["Biology","Medicine"],"doi":"10.1038/nrmicro1892","url":"https://www.semanticscholar.org/paper/c3cc6d656df9ac30dbc6ce845ed8443a3c6f1e10","is_open_access":true,"citations":2184,"published_at":"","score":82},{"id":"ss_679b77f9c63fefa0d1e9039eb72d6844c1d02fc2","title":"Applications of CRISPR–Cas in agriculture and plant biotechnology","authors":[{"name":"Haocheng Zhu"},{"name":"Chao Li"},{"name":"Caixia Gao"}],"abstract":"","source":"Semantic Scholar","year":2020,"language":"en","subjects":["Medicine","Computer Science"],"doi":"10.1038/s41580-020-00288-9","url":"https://www.semanticscholar.org/paper/679b77f9c63fefa0d1e9039eb72d6844c1d02fc2","is_open_access":true,"citations":580,"published_at":"","score":81.4},{"id":"ss_ebf8c07cc82b7bfae8d22c7791c5907bdb0d7881","title":"Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology.","authors":[{"name":"W. Powell"},{"name":"K. Koput"},{"name":"Laurel Smith‐Doerr"}],"abstract":"","source":"Semantic Scholar","year":1996,"language":"en","subjects":["Sociology"],"doi":"10.2307/2393988","url":"https://www.semanticscholar.org/paper/ebf8c07cc82b7bfae8d22c7791c5907bdb0d7881","is_open_access":true,"citations":8888,"published_at":"","score":80},{"id":"ss_bb173bbe6cdc72ccace40d0d265facccb0f17f44","title":"Microbial Cellulose Utilization: Fundamentals and Biotechnology","authors":[{"name":"L. Lynd"},{"name":"P. Weimer"},{"name":"W. V. van Zyl"},{"name":"I. S. Pretorius"}],"abstract":"","source":"Semantic Scholar","year":2002,"language":"en","subjects":["Biology","Medicine"],"doi":"10.1128/MMBR.66.3.506-577.2002","url":"https://www.semanticscholar.org/paper/bb173bbe6cdc72ccace40d0d265facccb0f17f44","pdf_url":"https://europepmc.org/articles/pmc120791?pdf=render","is_open_access":true,"citations":4851,"published_at":"","score":80},{"id":"ss_43ccbe838183defbcd1bf4af8a1590346c8beea1","title":"Don't go it alone: alliance network composition and startups' performance in Canadian biotechnology","authors":[{"name":"Joel A. C. Baum"},{"name":"Tony Calabrese"},{"name":"B. Silverman"}],"abstract":"","source":"Semantic Scholar","year":2000,"language":"en","subjects":["Business"],"doi":"10.1002/(SICI)1097-0266(200003)21:3\u003c267::AID-SMJ89\u003e3.0.CO;2-8","url":"https://www.semanticscholar.org/paper/43ccbe838183defbcd1bf4af8a1590346c8beea1","is_open_access":true,"citations":2808,"published_at":"","score":80},{"id":"ss_f37e3fdb418ff81affd25b2b9971c45359b46053","title":"Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.","authors":[{"name":"Brenda Winkel-Shirley"}],"abstract":"","source":"Semantic Scholar","year":2001,"language":"en","subjects":["Biology","Medicine"],"doi":"10.1104/PP.126.2.485","url":"https://www.semanticscholar.org/paper/f37e3fdb418ff81affd25b2b9971c45359b46053","pdf_url":"https://academic.oup.com/plphys/article-pdf/126/2/485/38680729/plphys_v126_2_485.pdf","is_open_access":true,"citations":3326,"published_at":"","score":80},{"id":"ss_2e520ea6aee7cc2bd96726eff7c726915521a295","title":"Tissue engineering : Frontiers in biotechnology","authors":[{"name":"R. Langer"},{"name":"J. Vacanti"}],"abstract":"","source":"Semantic Scholar","year":1993,"language":"en","subjects":["Materials Science"],"url":"https://www.semanticscholar.org/paper/2e520ea6aee7cc2bd96726eff7c726915521a295","is_open_access":true,"citations":5519,"published_at":"","score":80},{"id":"ss_00bc156bac2b39fab1689fe047b23c9f216d7f29","title":"Database resources of the National Center for Biotechnology Information: update","authors":[{"name":"David L. Wheeler"},{"name":"D. Church"},{"name":"Ron Edgar"},{"name":"S. Federhen"},{"name":"W. Helmberg"},{"name":"Thomas L. Madden"},{"name":"J. Pontius"},{"name":"G. Schuler"},{"name":"L. Schriml"},{"name":"Edwin Sequeira"},{"name":"Tugba Onal Suzek"},{"name":"T. Tatusova"},{"name":"L. Wagner"}],"abstract":"In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI’s website. NCBI resources include Entrez, PubMed, PubMed Central, LocusLink, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SARS Coronavirus Resource, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov.","source":"Semantic Scholar","year":2004,"language":"en","subjects":["Biology","Medicine"],"doi":"10.1093/nar/gkh073","url":"https://www.semanticscholar.org/paper/00bc156bac2b39fab1689fe047b23c9f216d7f29","pdf_url":"https://europepmc.org/articles/pmc308807","is_open_access":true,"citations":2668,"published_at":"","score":80},{"id":"ss_211a8365e94d10d34249eb41d22efcd76263b607","title":"Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community","authors":[{"name":"Jason Owen-Smith"},{"name":"W. Powell"}],"abstract":"","source":"Semantic Scholar","year":2004,"language":"en","subjects":["Economics","Computer Science"],"doi":"10.1287/orsc.1030.0054","url":"https://www.semanticscholar.org/paper/211a8365e94d10d34249eb41d22efcd76263b607","is_open_access":true,"citations":2316,"published_at":"","score":80},{"id":"ss_2e47a884fd55ab8ae1b244cae60129bba18e56c6","title":"Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology","authors":[{"name":"Nicholas S. McCarty"},{"name":"R. Ledesma‐Amaro"}],"abstract":"Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioproduction of medicines, biofuels, and biomaterials from inexpensive carbon sources. An improved understanding of natural microbial ecosystems, and the development of new tools to construct synthetic consortia and program their behaviors, will vastly expand the functions that can be performed by communities of interacting microorganisms. Here, we review recent advancements in synthetic biology tools and approaches to engineer synthetic microbial consortia, discuss ongoing and emerging efforts to apply consortia for various biotechnological applications, and suggest future applications.","source":"Semantic Scholar","year":2019,"language":"en","subjects":["Engineering","Medicine"],"doi":"10.1016/j.tibtech.2018.11.002","url":"https://www.semanticscholar.org/paper/2e47a884fd55ab8ae1b244cae60129bba18e56c6","pdf_url":"https://www.cell.com/trends/biotechnology/pdf/S0167-7799(18)30312-3.pdf","is_open_access":true,"citations":447,"published_at":"","score":76.41},{"id":"ss_099c799b0114b981747f7692fe962172e3727d4a","title":"AI for Life: Trends in Artificial Intelligence for Biotechnology.","authors":[{"name":"Andreas Holzinger"},{"name":"K. Keiblinger"},{"name":"P. Holub"},{"name":"K. Zatloukal"},{"name":"Heimo Müller"}],"abstract":"Due to popular successes (e.g., ChatGPT) Artificial Intelligence (AI) is on everyone's lips today. When advances in biotechnology are combined with advances in AI unprecedented new potential solutions become available. This can help with many global problems and contribute to important Sustainability Development Goals. Current examples include Food Security, Health and Well-being, Clean Water, Clean Energy, Responsible Consumption and Production, Climate Action, Life below Water, or protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss. AI is ubiquitous in the life sciences today. Topics include a wide range from machine learning and Big Data analytics, knowledge discovery and data mining, biomedical ontologies, knowledge-based reasoning, natural language processing, decision support and reasoning under uncertainty, temporal and spatial representation and inference, and methodological aspects of explainable AI (XAI) with applications of biotechnology. In this pre-Editorial paper, we provide an overview of open research issues and challenges for each of the topics addressed in this special issue. Potential authors can directly use this as a guideline for developing their paper.","source":"Semantic Scholar","year":2023,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.nbt.2023.02.001","url":"https://www.semanticscholar.org/paper/099c799b0114b981747f7692fe962172e3727d4a","pdf_url":"https://doi.org/10.1016/j.nbt.2023.02.001","is_open_access":true,"citations":299,"published_at":"","score":75.97},{"id":"ss_3f797f4d269eee20608fae3f32bb2f8d14387658","title":"Hypes, hopes, and the way forward for microalgal biotechnology.","authors":[{"name":"M. Barbosa"},{"name":"M. Janssen"},{"name":"Christian Südfeld"},{"name":"Sarah D’Adamo"},{"name":"R. Wijffels"}],"abstract":"The urge for food security and sustainability has advanced the field of microalgal biotechnology. Microalgae are microorganisms able to grow using (sun)light, fertilizers, sugars, CO2, and seawater. They have high potential as a feedstock for food, feed, energy, and chemicals. Microalgae grow faster and have higher areal productivity than plant crops, without competing for agricultural land and with 100% efficiency uptake of fertilizers. In comparison with bacterial, fungal, and yeast single-cell protein production, based on hydrogen or sugar, microalgae show higher land-use efficiency. New insights are provided regarding the potential of microalgae replacing soy protein, fish oil, and palm oil and being used as cell factories in modern industrial biotechnology to produce designer feed, recombinant proteins, biopharmaceuticals, and vaccines.","source":"Semantic Scholar","year":2023,"language":"en","subjects":["Medicine"],"doi":"10.1016/j.tibtech.2022.12.017","url":"https://www.semanticscholar.org/paper/3f797f4d269eee20608fae3f32bb2f8d14387658","pdf_url":"https://doi.org/10.1016/j.tibtech.2022.12.017","is_open_access":true,"citations":134,"published_at":"","score":71.02000000000001}],"total":1000430,"page":1,"page_size":20,"sources":["CrossRef","arXiv","DOAJ","Semantic Scholar"],"query":"Biotechnology"}