Semantic Scholar Open Access 2020 254 sitasi

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

P. Norat Sauson Soldozy J. Sokolowski C. Gorick J. Kumar +8 lainnya

Lihat Sumber DOI

Abstrak

Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to establish appropriate electrochemical gradients and reliable synaptic transmission. Notably, several mitochondrial defects have been identified in central nervous system disorders. Membrane leakage and electrolyte imbalances, pro-apoptotic pathway activation, and mitophagy are among the mechanisms implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s disease, as well as ischemic stroke. In this review, we summarize mitochondrial pathways that contribute to disease progression. Further, we discuss pathological states that damaged mitochondria impose on normal nervous system processes and explore new therapeutic approaches to mitochondrial diseases.

Topik & Kata Kunci

Medicine

Penulis (13)

P. Norat

Sauson Soldozy

J. Sokolowski

C. Gorick

J. Kumar

Youngrok Chae

Kaan Yağmurlu

Francesco Prada

M. Walker

M. Levitt

R. Price

P. Tvrdik

M. Kalani

Format Sitasi

APA MLA BibTeX

Norat, P., Soldozy, S., Sokolowski, J., Gorick, C., Kumar, J., Chae, Y. et al. (2020). Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation. https://doi.org/10.1038/s41536-020-00107-x

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41536-020-00107-x

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 254×
Sumber Database: Semantic Scholar
DOI: 10.1038/s41536-020-00107-x
Akses: Open Access ✓