Semantic Scholar Open Access 2025 1 sitasi

The immune microenvironment in tumors: focus on canine and feline spontaneous neoplasms

M. Rizzi G. D’Annunzio Chiara Tugnoli G. Sarli L. V. Muscatello

Abstrak

Companion animals develop spontaneous tumors with biological and immunological features closely resembling human cancers. The tumor microenvironment (TME), particularly its immune infiltrates, plays a pivotal role in tumor progression and immune evasion. This review summarizes current knowledge on the composition and function of immune cells (including T cells, B cells, macrophages, dendritic cells, neutrophils, and mast cells) in the TME of canine and feline tumors. A better understanding of these mechanisms may aid in identifying prognostic biomarkers and novel immunotherapeutic targets in both veterinary and human oncology.

Topik & Kata Kunci

Medicine

Penulis (5)

M. Rizzi

G. D’Annunzio

Chiara Tugnoli

G. Sarli

L. V. Muscatello

Format Sitasi

APA MLA BibTeX

Rizzi, M., D’Annunzio, G., Tugnoli, C., Sarli, G., Muscatello, L.V. (2025). The immune microenvironment in tumors: focus on canine and feline spontaneous neoplasms. https://doi.org/10.3389/fvets.2025.1674694

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Informasi Jurnal

Tahun Terbit: 2025
Bahasa: en
Total Sitasi: 1×
Sumber Database: Semantic Scholar
DOI: 10.3389/fvets.2025.1674694
Akses: Open Access ✓