Semantic Scholar Open Access 2014 256 sitasi

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

Xinpeng Ma Yiguang Wang Tian Zhao Yang Li Lee-Chun Su +4 lainnya

Lihat Sumber DOI

Abstrak

pH is an important physiological parameter that plays a critical role in cellular and tissue homeostasis. Conventional small molecular pH sensors (e.g., fluorescein, Lysosensor) are limited by broad pH response and restricted fluorescent emissions. Previously, we reported the development of ultra-pH-sensitive (UPS) nanoprobes with sharp pH response using fluorophores with small Stokes shifts (50-fold between on and off states). The UPS library provides a useful toolkit to study pH regulation in many pathophysiological indications (e.g., cancer, lysosome catabolism) as well as establishing tumor-activatable systems for cancer imaging and drug delivery.

Topik & Kata Kunci

Medicine Chemistry

Penulis (9)

Xinpeng Ma

Yiguang Wang

Tian Zhao

Yang Li

Lee-Chun Su

Zhaohui Wang

Gang Huang

B. Sumer

Jinming Gao

Format Sitasi

APA MLA BibTeX

Ma, X., Wang, Y., Zhao, T., Li, Y., Su, L., Wang, Z. et al. (2014). Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions. https://doi.org/10.1021/ja5053158

Akses Cepat

Lihat di Sumber doi.org/10.1021/ja5053158

Informasi Jurnal

Tahun Terbit: 2014
Bahasa: en
Total Sitasi: 256×
Sumber Database: Semantic Scholar
DOI: 10.1021/ja5053158
Akses: Open Access ✓