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Semantic Scholar Open Access 2021 3594 sitasi

eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale

C. Cantalapiedra Ana Hernández-Plaza Ivica Letunic P. Bork J. Huerta-Cepas
Lihat Sumber DOI

Abstrak

Even though automated functional annotation of genes represents a fundamental step in most genomic and metagenomic workflows, it remains challenging at large scales. Here, we describe a major upgrade to eggNOG-mapper, a tool for functional annotation based on precomputed orthology assignments, now optimized for vast (meta)genomic data sets. Improvements in version 2 include a full update of both the genomes and functional databases to those from eggNOG v5, as well as several efficiency enhancements and new features. Most notably, eggNOG-mapper v2 now allows: (i) de novo gene prediction from raw contigs, (ii) built-in pairwise orthology prediction, (iii) fast protein domain discovery, and (iv) automated GFF decoration. eggNOG-mapper v2 is available as a standalone tool or as an online service at http://eggnog-mapper.embl.de.

Topik & Kata Kunci

Medicine Biology

Penulis (5)

C

C. Cantalapiedra

A

Ana Hernández-Plaza

I

Ivica Letunic

P

P. Bork

J

J. Huerta-Cepas

Format Sitasi

APA MLA BibTeX
Cantalapiedra, C., Hernández-Plaza, A., Letunic, I., Bork, P., Huerta-Cepas, J. (2021). eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale. https://doi.org/10.1101/2021.06.03.446934

Akses Cepat

Lihat di Sumber doi.org/10.1101/2021.06.03.446934
Informasi Jurnal
Tahun Terbit
2021
Bahasa
en
Total Sitasi
3594×
Sumber Database
Semantic Scholar
DOI
10.1101/2021.06.03.446934
Akses
Open Access ✓