Semantic Scholar
Open Access
2015
940 sitasi
The Economics of Reproducibility in Preclinical Research
L. Freedman
I. Cockburn
Timothy S. Simcoe
Abstrak
Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B)/year spent on preclinical research that is not reproducible—in the United States alone. We outline a framework for solutions and a plan for long-term improvements in reproducibility rates that will help to accelerate the discovery of life-saving therapies and cures.
Penulis (3)
L
L. Freedman
I
I. Cockburn
T
Timothy S. Simcoe
Akses Cepat
Informasi Jurnal
- Tahun Terbit
- 2015
- Bahasa
- en
- Total Sitasi
- 940×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1371/journal.pbio.1002165
- Akses
- Open Access ✓