Semantic Scholar Open Access 2021 116 sitasi

Neurological complications and infection mechanism of SARS-CoV-2

Dandan Wan Tingfu Du Weiqi Hong Li Chen H. Que +2 lainnya

Lihat Sumber DOI

Abstrak

Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.

Topik & Kata Kunci

Medicine

Penulis (7)

Dandan Wan

Tingfu Du

Weiqi Hong

Li Chen

H. Que

Shuaiyao Lu

Xiaozhong Peng

Format Sitasi

APA MLA BibTeX

Wan, D., Du, T., Hong, W., Chen, L., Que, H., Lu, S. et al. (2021). Neurological complications and infection mechanism of SARS-CoV-2. https://doi.org/10.1038/s41392-021-00818-7

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41392-021-00818-7

Informasi Jurnal

Tahun Terbit: 2021
Bahasa: en
Total Sitasi: 116×
Sumber Database: Semantic Scholar
DOI: 10.1038/s41392-021-00818-7
Akses: Open Access ✓