Semantic Scholar Open Access 2019 406 sitasi

pH-Responsive Polymer Nanoparticles for Drug Delivery.

Nayeleh Deirram Changhe Zhang Sarah S. Kermaniyan A. Johnston Georgina K. Such

Lihat Sumber DOI

Abstrak

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.

Topik & Kata Kunci

Chemistry Medicine

Penulis (5)

Nayeleh Deirram

Changhe Zhang

Sarah S. Kermaniyan

A. Johnston

Georgina K. Such

Format Sitasi

APA MLA BibTeX

Deirram, N., Zhang, C., Kermaniyan, S.S., Johnston, A., Such, G.K. (2019). pH-Responsive Polymer Nanoparticles for Drug Delivery.. https://doi.org/10.1002/marc.201800917

Akses Cepat

Lihat di Sumber doi.org/10.1002/marc.201800917

Informasi Jurnal

Tahun Terbit: 2019
Bahasa: en
Total Sitasi: 406×
Sumber Database: Semantic Scholar
DOI: 10.1002/marc.201800917
Akses: Open Access ✓