Semantic Scholar Open Access 2014 484 sitasi

The Genetics of Major Depression

J. Flint K. Kendler

Lihat Sumber DOI

Abstrak

Major depression is the commonest psychiatric disorder and in the U.S. has the greatest impact of all biomedical diseases on disability. Here we review evidence of the genetic contribution to disease susceptibility and the current state of molecular approaches. Genome-wide association and linkage results provide constraints on the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the voluminous candidate gene literature. We consider evidence for the genetic heterogeneity of the disorder and the likelihood that subtypes exist that represent more genetically homogenous conditions than have hitherto been analyzed.

Topik & Kata Kunci

Biology Medicine

Penulis (2)

J. Flint

K. Kendler

Format Sitasi

APA MLA BibTeX

Flint, J., Kendler, K. (2014). The Genetics of Major Depression. https://doi.org/10.1016/j.neuron.2014.01.027

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.neuron.2014.01.027

Informasi Jurnal

Tahun Terbit: 2014
Bahasa: en
Total Sitasi: 484×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.neuron.2014.01.027
Akses: Open Access ✓