MORPHOFUNCTIONAL REMODELING OF THE GASTRIC WALL UNDER THE INFLUENCE OF ENDOGENOUS AND EXOGENOUS FACTORS

Morphological changes in the gastric wall under the influence of various pathological factors represent one of the most pressing problems in modern gastroenterology and morphology. The stomach, as one of the central organs of the digestive system, is characterized by high plasticity and adaptive properties in response to various endogenous and exogenous factors. Understanding the processes of structural remodeling of the gastric mucosa is essential for developing effective therapeutic agents for gastrointestinal tract diseases. Despite significant progress in studying the features of gastric wall remodeling, many factors of this process remain insufficiently studied. In particular, the relationships between different types of pathogenic influences and characteristic morphological changes require more detailed investigation. The aim of the study is to systematize and analyze current scientific data on morphofunctional changes in the gastric wall under the influence of the following exogenous and endogenous factors: radiation damage, compressive loading, electron ionization, bariatric surgery, heavy metals, toxic effects of cadmium and copper, tetrabromobisphenol A, indomethacin, acetylsalicylic acid, ibuprofen, food additives, as well as dehydration, diabetes mellitus, inflammatory processes, chronic alcoholic hepatitis, concomitant thyroid pathology with atrophic gastritis, autoimmune atrophic gastritis in systemic scleroderma, and cancer diseases. The results of the analysis will contribute to the development of scientifically-based approaches for the prevention and treatment of gastroenterological diseases.