Semantic Scholar Open Access 2012 59 sitasi

Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system

S. Sirohi G. Bakalkin B. Walker

Lihat Sumber DOI

Abstrak

Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system (EOS) has been strongly implicated in the positive and negative reinforcing effects of alcohol. Traditionally recognized as dysphoric/anhedonic in nature, the dynorphin/kappa-opioid receptor (DYN/KOR) system has recently received considerable attention due to evidence suggesting that an upregulated DYN/KOR system may be a critical contributor to the complex factors that result in escalated alcohol consumption once dependent. The present review will discuss alcohol-induced plasticity in the DYN/KOR system and how these neuroadaptations could contribute to excessive alcohol seeking and consumption.

Topik & Kata Kunci

Psychology Medicine

Penulis (3)

S. Sirohi

G. Bakalkin

B. Walker

Format Sitasi

APA MLA BibTeX

Sirohi, S., Bakalkin, G., Walker, B. (2012). Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. https://doi.org/10.3389/fnmol.2012.00095

Akses Cepat

Lihat di Sumber doi.org/10.3389/fnmol.2012.00095

Informasi Jurnal

Tahun Terbit: 2012
Bahasa: en
Total Sitasi: 59×
Sumber Database: Semantic Scholar
DOI: 10.3389/fnmol.2012.00095
Akses: Open Access ✓