Semantic Scholar Open Access 2020 367 sitasi

PROTACs: An Emerging Therapeutic Modality in Precision Medicine.

Dhanusha A. Nalawansha C. Crews

Lihat Sumber DOI

Abstrak

Targeted protein degradation (TPD) has emerged as an exciting new era in chemical biology and drug discovery. PROteolysis TArgeting Chimera (PROTAC) technology targets cellular proteins for degradation by co-opting the ubiquitin-proteasome system. Over the last 5 years, numerous studies have expanded our understanding of the unique mode of action and advantages of PROTACs, which has in turn spurred interest in both academia and industry to explore PROTACs as a novel therapeutic strategy. In this review, we first highlight the key advantages of PROTACs and then discuss the spatiotemporal regulation of protein degradation. Next, we explore current chemically tractable E3 ligases focusing on expanding the existing repertoire with novel E3 ligases to uncover the full potential of TPD. Collectively, these studies are guiding the development of the PROTAC technology as it emerges as a new modality in precision medicine.

Topik & Kata Kunci

Biology Medicine

Penulis (2)

Dhanusha A. Nalawansha

C. Crews

Format Sitasi

APA MLA BibTeX

Nalawansha, D.A., Crews, C. (2020). PROTACs: An Emerging Therapeutic Modality in Precision Medicine.. https://doi.org/10.1016/j.chembiol.2020.07.020

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.chembiol.2020.07.020

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 367×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.chembiol.2020.07.020
Akses: Open Access ✓