Semantic Scholar Open Access 2020 207 sitasi

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

A. Molinaro Pierre Bel Lassen Marcus Henricsson Hao Wu S. Adriouch +106 lainnya

Lihat Sumber DOI

Abstrak

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

Topik & Kata Kunci

Medicine Chemistry

Penulis (111)

A. Molinaro

Pierre Bel Lassen

Marcus Henricsson

Hao Wu

S. Adriouch

Eugeni Belda

R. Chakaroun

T. Nielsen

Per-Olof Bergh

C. Rouault

S. André

Florian Marquet

F. Andreelli

J. Salem

K. Assmann

J. Bastard

Sofia K. Forslund

E. Le Chatelier

G. Falony

N. Pons

Edi Prifti

B. Quinquis

H. Roume

S. Vieira-Silva

T. Hansen

H. Pedersen

C. Lewinter

Nadja B Sønderskov

Renato Chloe Ehm Astrid Andersson Olivier Jean-Paul Magal Alves Amouyal Galijatovic Barthelemy Batisse Berla

Renato J Alves

C. Amouyal

Ehm Astrid Andersson Galijatovic

O. Barthelemy

J. Batisse

M. Berland

R. Bittar

H. Blottière

Frédéric Bosquet

Rachid Boubrit

O. Bourron

M. Camus

D. Cassuto

J. Chilloux

C. Ciangura

Luis Pedro Coelho

J. Collet

M. Dao

M. Djebbar

A. Doré

L. Engelbrechtsen

S. Fellahi

L. Fezeu

S. Fromentin

P. Giral

J. Gøtze

A. Hartemann

J. Holst

S. Hercberg

G. Helft

M. Hornbak

J. Hulot

R. Isnard

Sophie Jaqueminet

N. Jørgensen

Hanna Julienne

J. Justesen

J. Kammer

N. Krarup

M. Kerneis

J. Khemis

N. B. Kristensen

Michael Kuhn

V. Léjard

F. Levenez

Léa Lucas-Martini

Robin Massey

N. Maziers

Jonathan Medina-Stamminger

G. Montalescot

S. Moutel

Laetitia Pasero Le Pavin

C. Poitou

F. Pousset

Laurence Pouzoulet

Sebastien Schmidt

L. Moitinho-Silva

J. Silvain

Nataliya Sokolovska

Sothea Touch

Mathilde Svendstrup

Timothy Swartz

Thierry Vanduyvenboden

C. Vatier

Stefan Walther

L. Køber

H. Vestergaard

T. Hansen

Jean-Daniel Zucker

P. Galan

M. Dumas

J. Raes

J. Oppert

Ivica Letunic

J. Nielsen

P. Bork

S. Ehrlich

M. Stumvoll

O. Pedersen

J. Aron‐Wisnewsky

K. Clément

F. Bäckhed

Format Sitasi

APA MLA BibTeX

Molinaro, A., Lassen, P.B., Henricsson, M., Wu, H., Adriouch, S., Belda, E. et al. (2020). Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. https://doi.org/10.1038/s41467-020-19589-w

@article{molinaro2020, author = {A. Molinaro and Pierre Bel Lassen and Marcus Henricsson and Hao Wu and S. Adriouch and Eugeni Belda and R. Chakaroun and T. Nielsen and Per-Olof Bergh and C. Rouault and S. André and Florian Marquet and F. Andreelli and J. Salem and K. Assmann and J. Bastard and Sofia K. Forslund and E. Le Chatelier and G. Falony and N. Pons and Edi Prifti and B. Quinquis and H. Roume and S. Vieira-Silva and T. Hansen and H. Pedersen and C. Lewinter and Nadja B Sønderskov and Renato Chloe Ehm Astrid Andersson Olivier Jean-Paul Magal Alves Amouyal Galijatovic Barthelemy Batisse Berla and Renato J Alves and C. Amouyal and Ehm Astrid Andersson Galijatovic and O. Barthelemy and J. Batisse and M. Berland and R. Bittar and H. Blottière and Frédéric Bosquet and Rachid Boubrit and O. Bourron and M. Camus and D. Cassuto and J. Chilloux and C. Ciangura and Luis Pedro Coelho and J. Collet and M. Dao and M. Djebbar and A. Doré and L. Engelbrechtsen and S. Fellahi and L. Fezeu and S. Fromentin and P. Giral and J. Gøtze and A. Hartemann and J. Holst and S. Hercberg and G. Helft and M. Hornbak and J. Hulot and R. Isnard and Sophie Jaqueminet and N. Jørgensen and Hanna Julienne and J. Justesen and J. Kammer and N. Krarup and M. Kerneis and J. Khemis and N. B. Kristensen and Michael Kuhn and V. Léjard and F. Levenez and Léa Lucas-Martini and Robin Massey and N. Maziers and Jonathan Medina-Stamminger and G. Montalescot and S. Moutel and Laetitia Pasero Le Pavin and C. Poitou and F. Pousset and Laurence Pouzoulet and Sebastien Schmidt and L. Moitinho-Silva and J. Silvain and Nataliya Sokolovska and Sothea Touch and Mathilde Svendstrup and Timothy Swartz and Thierry Vanduyvenboden and C. Vatier and Stefan Walther and L. Køber and H. Vestergaard and T. Hansen and Jean-Daniel Zucker and P. Galan and M. Dumas and J. Raes and J. Oppert and Ivica Letunic and J. Nielsen and P. Bork and S. Ehrlich and M. Stumvoll and O. Pedersen and J. Aron‐Wisnewsky and K. Clément and F. Bäckhed}, title = {Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology}, year = {2020}, journal = {Semantic Scholar}, doi = {10.1038/s41467-020-19589-w}, url = {https://www.semanticscholar.org/paper/d9ddc753e2b80a0283205e5fb10e5d9f9147befe}, }

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41467-020-19589-w

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 207×
Sumber Database: Semantic Scholar
DOI: 10.1038/s41467-020-19589-w
Akses: Open Access ✓