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Semantic Scholar Open Access 1996 432 sitasi

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

H. Sluss Z. Han T. Barrett D. Goberdhan C. Wilson +2 lainnya
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Abstrak

The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and join at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.

Topik & Kata Kunci

Medicine Biology

Penulis (7)

H

H. Sluss

Z

Z. Han

T

T. Barrett

D

D. Goberdhan

C

C. Wilson

R

R. Davis

Y

Y. Ip

Format Sitasi

APA MLA BibTeX
Sluss, H., Han, Z., Barrett, T., Goberdhan, D., Wilson, C., Davis, R. et al. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.. https://doi.org/10.1101/GAD.10.21.2745

Akses Cepat

Lihat di Sumber doi.org/10.1101/GAD.10.21.2745
Informasi Jurnal
Tahun Terbit
1996
Bahasa
en
Total Sitasi
432×
Sumber Database
Semantic Scholar
DOI
10.1101/GAD.10.21.2745
Akses
Open Access ✓