Cavity optomechanical spring sensing of single molecules
Abstrak
Label-free bio-sensing is a critical functionality underlying a variety of health- and security-related applications. Micro-/nano-photonic devices are well suited for this purpose and have emerged as promising platforms in recent years. Here we propose and demonstrate an approach that utilizes the optical spring effect in a high-Q coherent optomechanical oscillator to dramatically enhance the sensing resolution by orders of magnitude compared with conventional approaches, allowing us to detect single bovine serum albumin proteins with a molecular weight of 66 kDa at a signal-to-noise ratio of 16.8. The unique optical spring sensing approach opens up a distinctive avenue that not only enables biomolecule sensing and recognition at individual level, but is also of great promise for broad physical sensing applications that rely on sensitive detection of optical cavity resonance shift to probe external physical parameters. Detection of a single nanoparticle or molecule is essential for many applications. Here, Yu et al.demonstrate the use of an optical cavity with optomechanical oscillation to detect single bovine serum albumin proteins, with potential for studying mechanical properties and interactions of individual molecules.
Penulis (4)
Wenyan Yu
Wei C. Jiang
Q. Lin
T. Lu
Akses Cepat
- Tahun Terbit
- 2015
- Bahasa
- en
- Total Sitasi
- 213×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1038/ncomms12311
- Akses
- Open Access ✓