Semantic Scholar Open Access 2016 700 sitasi

Molecular Evolution of Human Coronavirus Genomes

D. Forni R. Cagliani M. Clerici M. Sironi

Lihat Sumber DOI

Abstrak

Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. Video Abstract

Topik & Kata Kunci

Medicine Biology

Penulis (4)

D. Forni

R. Cagliani

M. Clerici

M. Sironi

Format Sitasi

APA MLA BibTeX

Forni, D., Cagliani, R., Clerici, M., Sironi, M. (2016). Molecular Evolution of Human Coronavirus Genomes. https://doi.org/10.1016/j.tim.2016.09.001

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.tim.2016.09.001

Informasi Jurnal

Tahun Terbit: 2016
Bahasa: en
Total Sitasi: 700×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.tim.2016.09.001
Akses: Open Access ✓