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Semantic Scholar Open Access 2019 110 sitasi

miRNAs as Therapeutic Targets in Inflammatory Disease.

Q. Lu R. Wu Ming Zhao Antonio Garcia-Gomez E. Ballestar
Lihat Sumber DOI

Abstrak

In the past decade, we have witnessed considerable developments in understanding the roles and functions of miRNAs. In parallel, the identification of alterations in miRNA expression in inflammatory disease indicates their potential as therapeutic targets. Pharmacological treatments targeting abnormally expressed miRNAs for inflammatory diseases are not yet in clinical practice; however, some small compounds and nucleic acids targeting miRNAs have shown promise in preclinical development. Here, we focus on recent advances in understanding miRNA deregulation in inflammatory diseases and provide an overview of the current development of miRNA-based therapeutics in these diseases with an emphasis on newly discovered miRNA therapeutic targets.

Topik & Kata Kunci

Medicine

Penulis (5)

Q

Q. Lu

R

R. Wu

M

Ming Zhao

A

Antonio Garcia-Gomez

E

E. Ballestar

Format Sitasi

APA MLA BibTeX
Lu, Q., Wu, R., Zhao, M., Garcia-Gomez, A., Ballestar, E. (2019). miRNAs as Therapeutic Targets in Inflammatory Disease.. https://doi.org/10.1016/j.tips.2019.09.007

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Lihat di Sumber doi.org/10.1016/j.tips.2019.09.007
Informasi Jurnal
Tahun Terbit
2019
Bahasa
en
Total Sitasi
110×
Sumber Database
Semantic Scholar
DOI
10.1016/j.tips.2019.09.007
Akses
Open Access ✓