Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine
Abstrak
Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1–11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein. Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases).
Penulis (8)
N. Bruni
M. Capucchio
E. Biasibetti
E. Pessione
S. Cirrincione
L. Giraudo
A. Corona
F. Dosio
Akses Cepat
- Tahun Terbit
- 2016
- Bahasa
- en
- Total Sitasi
- 199×
- Sumber Database
- Semantic Scholar
- DOI
- 10.3390/molecules21060752
- Akses
- Open Access ✓