Semantic Scholar Open Access 2021 11 sitasi

Role of clusterin in the regulation of trophoblast development and preeclampsia.

Shanshui Zeng Yue Pan Fei Liu Ji-peng Yin Min Jiang +4 lainnya

Abstrak

Preeclampsia (PE) threatens the safety of mothers and fetuses, and its pathogenesis is still unclear. Our previous study has found the relationship between PE and serum Clusterin (CLU). This study aimed to investigate the role of CLU on PE. Firstly, levels of CLU in serum and placental tissue from PE patients and healthy pregnancies were compared. Then, RNA sequencing, cell counting kit-8, matrigel invasion, cell apoptosis, and angiogenesis assay were performed to evaluate the role of CLU on primary isolation trophoblast cells. We found the expression of CLU was increased before the clinical syndrome occurred, whereas its level was positively related to the severity of PE. CLU significantly inhibited the expression of matrix metalloproteinase-9 and Vimentin and enhanced E-cadherin to inhibit epithelial-mesenchymal transition of trophoblast cells, further reducing its migration and invasion. Our results suggested that CLU may play a role in regulating trophoblast invasion and migration during placental development, which may be one of the risk factors for PE.

Topik & Kata Kunci

Medicine

Penulis (9)

Shanshui Zeng

Yue Pan

Fei Liu

Ji-peng Yin

Min Jiang

Yan Long

Xueqin Zhao

G. Lash

Hongling Yang

Format Sitasi

APA MLA BibTeX

Zeng, S., Pan, Y., Liu, F., Yin, J., Jiang, M., Long, Y. et al. (2021). Role of clusterin in the regulation of trophoblast development and preeclampsia.. https://doi.org/10.1016/j.bbrc.2021.10.064

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Informasi Jurnal

Tahun Terbit: 2021
Bahasa: en
Total Sitasi: 11×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.bbrc.2021.10.064
Akses: Open Access ✓