Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases
Abstrak
Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator β-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/β-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/β-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer’s disease, Parkinson’s disease, and depression.
Penulis (4)
Juanmei Gao
Yuan Liao
M. Qiu
Wanhua Shen
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Total Sitasi
- 103×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1177/1073858420914509
- Akses
- Open Access ✓