Semantic Scholar Open Access 2015 948 sitasi

The cell biology of disease: Recent insights into the cellular biology of atherosclerosis

I. Tabas G. Garcı́a-Cardeña G. Owens

Lihat Sumber DOI

Abstrak

Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein retention. Over time, this process stimulates a nonresolving inflammatory response that can cause intimal destruction, arterial thrombosis, and end-organ ischemia. Recent advances highlight important cell biological atherogenic processes, including mechanotransduction and inflammatory processes in endothelial cells, origins and contributions of lesional macrophages, and origins and phenotypic switching of lesional smooth muscle cells. These advances illustrate how in-depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas for therapy.

Topik & Kata Kunci

Biology

Penulis (3)

I. Tabas

G. Garcı́a-Cardeña

G. Owens

Format Sitasi

APA MLA BibTeX

Tabas, I., Garcı́a-Cardeña, G., Owens, G. (2015). The cell biology of disease: Recent insights into the cellular biology of atherosclerosis. https://doi.org/10.1083/JCB.201412052

Akses Cepat

Lihat di Sumber doi.org/10.1083/JCB.201412052

Informasi Jurnal

Tahun Terbit: 2015
Bahasa: en
Total Sitasi: 948×
Sumber Database: Semantic Scholar
DOI: 10.1083/JCB.201412052
Akses: Open Access ✓