Semantic Scholar Open Access 2018 273 sitasi

Recent advances in metabolic engineering of Saccharomyces cerevisiae: New tools and their applications.

J. Lian Shekhar Mishra Huimin Zhao

Lihat Sumber DOI

Abstrak

Metabolic engineering aims to develop efficient cell factories by rewiring cellular metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae has been extensively engineered to produce a wide variety of products at high levels from various feedstocks. In this review, we summarize the recent development of metabolic engineering approaches to modulate yeast metabolism with representative examples. Particularly, we highlight new tools for biosynthetic pathway optimization (i.e. combinatorial transcriptional engineering and dynamic metabolic flux control) and genome engineering (i.e. clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) system based genome engineering and RNA interference assisted genome evolution) to advance metabolic engineering in yeast. We also discuss the challenges and perspectives for high throughput metabolic engineering.

Topik & Kata Kunci

Biology Medicine

Penulis (3)

J. Lian

Shekhar Mishra

Huimin Zhao

Format Sitasi

APA MLA BibTeX

Lian, J., Mishra, S., Zhao, H. (2018). Recent advances in metabolic engineering of Saccharomyces cerevisiae: New tools and their applications.. https://doi.org/10.1016/j.ymben.2018.04.011

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.ymben.2018.04.011

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 273×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.ymben.2018.04.011
Akses: Open Access ✓