Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system
Abstrak
Along with mounting evidence that gut microbiota and their metabolites migrate endogenously to distal organs, the ‘gut–lung axis,’ ‘gut–brain axis,’ ‘gut–liver axis’ and ‘gut–renal axis’ have been established. Multiple animal recent studies have demonstrated gut microbiota may also be a key susceptibility factor for neurological disorders such as Alzheimer's disease, Parkinson's disease and autism. The gastrointestinal tract is innervated by the extrinsic sympathetic and vagal nerves and the intrinsic enteric nervous system, and the gut microbiota interacts with the nervous system to maintain homeostatic balance in the host gut. A total of 1507 publications on the interactions between the gut microbiota, the gut–brain axis and neurological disorders are retrieved from the Web of Science to investigate the interactions between the gut microbiota and the nervous system and the underlying mechanisms involved in normal and disease states. We provide a comprehensive overview of the effects of the gut microbiota and its metabolites on nervous system function and neurotransmitter secretion, as well as alterations in the gut microbiota in neurological disorders, to provide a basis for the possibility of targeting the gut microbiota as a therapeutic agent for neurological disorders.
Topik & Kata Kunci
Penulis (8)
Yuhong He
Ke Wang
Niri Su
Chongshan Yuan
Nai-sheng Zhang
Xiaoyu Hu
Yunhe Fu
F. Zhao
Akses Cepat
- Tahun Terbit
- 2024
- Bahasa
- en
- Total Sitasi
- 40×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1111/jcmm.70099
- Akses
- Open Access ✓