Semantic Scholar Open Access 2018 196 sitasi

The Emerging Neurobiology of Bipolar Disorder

Paul J. Harrison J. Geddes E. Tunbridge

Lihat Sumber DOI

Abstrak

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.

Topik & Kata Kunci

Medicine Psychology

Penulis (3)

Paul J. Harrison

J. Geddes

E. Tunbridge

Format Sitasi

APA MLA BibTeX

Harrison, P.J., Geddes, J., Tunbridge, E. (2018). The Emerging Neurobiology of Bipolar Disorder. https://doi.org/10.1016/j.tins.2017.10.006

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.tins.2017.10.006

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 196×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.tins.2017.10.006
Akses: Open Access ✓