Semantic Scholar Open Access 2011 1876 sitasi

Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease

A. Naj G. Jun G. Beecham Li-San Wang B. Vardarajan +150 lainnya

Lihat Sumber DOI

Abstrak

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (PM) = 1.7 × 10−9, joint analysis P (PJ) = 1.7 × 10−9; stages 1, 2 and 3, PM = 8.2 × 10−12), CD2AP (rs9349407; stages 1, 2 and 3, PM = 8.6 × 10−9), EPHA1 (rs11767557; stages 1, 2 and 3, PM = 6.0 × 10−10) and CD33 (rs3865444; stages 1, 2 and 3, PM = 1.6 × 10−9). We also replicated previous associations at CR1 (rs6701713; PM = 4.6 × 10−10, PJ = 5.2 × 10−11), CLU (rs1532278; PM = 8.3 × 10−8, PJ = 1.9 × 10−8), BIN1 (rs7561528; PM = 4.0 × 10−14, PJ = 5.2 × 10−14) and PICALM (rs561655; PM = 7.0 × 10−11, PJ = 1.0 × 10−10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

Topik & Kata Kunci

Medicine Biology

Penulis (155)

A. Naj

G. Jun

G. Beecham

Li-San Wang

B. Vardarajan

Jacqueline Buros

P. Gallins

J. Buxbaum

G. Jarvik

P. Crane

E. Larson

T. Bird

B. Boeve

N. Graff-Radford

P. D. De Jager

Denis A. Evans

J. Schneider

M. Carrasquillo

N. Ertekin-Taner

S. Younkin

Carlos Cruchaga

J. Kauwe

P. Nowotny

P. Kramer

J. Hardy

M. Huentelman

A. Myers

M. Barmada

F. Y. Demirci

C. Baldwin

R. Green

E. Rogaeva

P. S. St George-Hyslop

S. Arnold

R. Barber

T. Beach

E. Bigio

J. Bowen

A. Boxer

J. Burke

N. Cairns

C. Carlson

R. Carney

S. Carroll

H. Chui

D. G. Clark

Jason J. Corneveaux

C. Cotman

J. Cummings

C. Decarli

S. DeKosky

R. Diaz-Arrastia

M. Dick

D. Dickson

W. Ellis

K. Faber

K. Fallon

M. Farlow

S. Ferris

M. Frosch

D. Galasko

M. Ganguli

M. Gearing

D. Geschwind

B. Ghetti

J. Gilbert

S. Gilman

Bruno Giordani

J. Glass

J. Growdon

R. Hamilton

L. Harrell

E. Head

L. Honig

C. Hulette

B. Hyman

G. Jicha

Lee‐way Jin

N. Johnson

J. Karlawish

A. Karydas

J. Kaye

R. Kim

E. Koo

N. Kowall

J. Lah

A. Levey

A. Lieberman

O. Lopez

W. Mack

D. Marson

F. Martiniuk

D. Mash

E. Masliah

W. McCormick

S. McCurry

A. McDavid

A. Mckee

M. Mesulam

B. Miller

C. Miller

Joshua W. Miller

J. Parisi

D. Perl

E. Peskind

R. Petersen

W. Poon

J. Quinn

Ruchita A Rajbhandary

M. Raskind

B. Reisberg

J. Ringman

E. Roberson

R. Rosenberg

M. Sano

L. Schneider

W. Seeley

M. Shelanski

M. Slifer

Charles D. Smith

J. Sonnen

S. Spina

R. Stern

R. Tanzi

J. Trojanowski

J. Troncoso

V. Deerlin

H. Vinters

J. Vonsattel

S. Weintraub

K. Welsh-Bohmer

J. Williamson

R. Woltjer

L. Cantwell

B. Dombroski

D. Beekly

K. Lunetta

E. Martin

M. I. Kamboh

A. Saykin

E. Reiman

D. Bennett

J. Morris

T. Montine

A. Goate

D. Blacker

D. Tsuang

H. Hakonarson

W. Kukull

T. Foroud

J. Haines

R. Mayeux

M. Pericak-Vance

L. Farrer

G. Schellenberg

Format Sitasi

APA MLA BibTeX

Naj, A., Jun, G., Beecham, G., Wang, L., Vardarajan, B., Buros, J. et al. (2011). Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease. https://doi.org/10.1038/ng.801

@article{naj2011, author = {A. Naj and G. Jun and G. Beecham and Li-San Wang and B. Vardarajan and Jacqueline Buros and P. Gallins and J. Buxbaum and G. Jarvik and P. Crane and E. Larson and T. Bird and B. Boeve and N. Graff-Radford and P. D. De Jager and Denis A. Evans and J. Schneider and M. Carrasquillo and N. Ertekin-Taner and S. Younkin and Carlos Cruchaga and J. Kauwe and P. Nowotny and P. Kramer and J. Hardy and M. Huentelman and A. Myers and M. Barmada and F. Y. Demirci and C. Baldwin and R. Green and E. Rogaeva and P. S. St George-Hyslop and S. Arnold and R. Barber and T. Beach and E. Bigio and J. Bowen and A. Boxer and J. Burke and N. Cairns and C. Carlson and R. Carney and S. Carroll and H. Chui and D. G. Clark and Jason J. Corneveaux and C. Cotman and J. Cummings and C. Decarli and S. DeKosky and R. Diaz-Arrastia and M. Dick and D. Dickson and W. Ellis and K. Faber and K. Fallon and M. Farlow and S. Ferris and M. Frosch and D. Galasko and M. Ganguli and M. Gearing and D. Geschwind and B. Ghetti and J. Gilbert and S. Gilman and Bruno Giordani and J. Glass and J. Growdon and R. Hamilton and L. Harrell and E. Head and L. Honig and C. Hulette and B. Hyman and G. Jicha and Lee‐way Jin and N. Johnson and J. Karlawish and A. Karydas and J. Kaye and R. Kim and E. Koo and N. Kowall and J. Lah and A. Levey and A. Lieberman and O. Lopez and W. Mack and D. Marson and F. Martiniuk and D. Mash and E. Masliah and W. McCormick and S. McCurry and A. McDavid and A. Mckee and M. Mesulam and B. Miller and C. Miller and Joshua W. Miller and J. Parisi and D. Perl and E. Peskind and R. Petersen and W. Poon and J. Quinn and Ruchita A Rajbhandary and M. Raskind and B. Reisberg and J. Ringman and E. Roberson and R. Rosenberg and M. Sano and L. Schneider and W. Seeley and M. Shelanski and M. Slifer and Charles D. Smith and J. Sonnen and S. Spina and R. Stern and R. Tanzi and J. Trojanowski and J. Troncoso and V. Deerlin and H. Vinters and J. Vonsattel and S. Weintraub and K. Welsh-Bohmer and J. Williamson and R. Woltjer and L. Cantwell and B. Dombroski and D. Beekly and K. Lunetta and E. Martin and M. I. Kamboh and A. Saykin and E. Reiman and D. Bennett and J. Morris and T. Montine and A. Goate and D. Blacker and D. Tsuang and H. Hakonarson and W. Kukull and T. Foroud and J. Haines and R. Mayeux and M. Pericak-Vance and L. Farrer and G. Schellenberg}, title = {Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease}, year = {2011}, journal = {Semantic Scholar}, doi = {10.1038/ng.801}, url = {https://www.semanticscholar.org/paper/ba3f3958986bb2daa2d2e820037216728d1c6afd}, }

Akses Cepat

Lihat di Sumber doi.org/10.1038/ng.801

Informasi Jurnal

Tahun Terbit: 2011
Bahasa: en
Total Sitasi: 1876×
Sumber Database: Semantic Scholar
DOI: 10.1038/ng.801
Akses: Open Access ✓