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Semantic Scholar Open Access 2016 714 sitasi

Neuronal activity enhances tau propagation and tau pathology in vivo

Jessica W. Wu S. A. Hussaini I. M. Bastille Gustavo A. Rodriguez Ana Mrejeru +13 lainnya
Lihat Sumber DOI

Abstrak

Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. Neuronal activity has been shown to regulate tau secretion, but its effect on tau pathology is unknown. Using optogenetic and chemogenetic approaches, we found that increased neuronal activity stimulates the release of tau in vitro and enhances tau pathology in vivo. These data have implications for disease pathogenesis and therapeutic strategies for Alzheimer's disease and other tauopathies.

Topik & Kata Kunci

Medicine Chemistry

Penulis (18)

J

Jessica W. Wu

S

S. A. Hussaini

I

I. M. Bastille

G

Gustavo A. Rodriguez

A

Ana Mrejeru

K

K. Rilett

D

David W. Sanders

C

C. Cook

H

H. Fu

R

Rick A C M Boonen

M

Mathieu Herman

E

Eden Nahmani

S

Sheina Emrani

Y

Y. Figueroa

M

Marc I Diamond

C

Catherine L. Clelland

S

S. Wray

K

Karen E. Duff

Format Sitasi

APA MLA BibTeX
Wu, J.W., Hussaini, S.A., Bastille, I.M., Rodriguez, G.A., Mrejeru, A., Rilett, K. et al. (2016). Neuronal activity enhances tau propagation and tau pathology in vivo. https://doi.org/10.1038/nn.4328

Akses Cepat

Lihat di Sumber doi.org/10.1038/nn.4328
Informasi Jurnal
Tahun Terbit
2016
Bahasa
en
Total Sitasi
714×
Sumber Database
Semantic Scholar
DOI
10.1038/nn.4328
Akses
Open Access ✓