Semantic Scholar Open Access 2020 787 sitasi

Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study

C. García-Vidal Gemma Sanjuán E. Moreno-García P. Puerta-Alcalde Nicole García-Poutón +40 lainnya

Lihat Sumber DOI

Abstrak

Objectives To describe the burden, epidemiology and outcomes of co-infections and superinfections occurring in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods We performed an observational cohort study of all consecutive patients admitted for ≥48 hours to the Hospital Clinic of Barcelona for COVID-19 (28 February to 22 April 2020) who were discharged or dead. We describe demographic, epidemiologic, laboratory and microbiologic results, as well as outcome data retrieved from electronic health records. Results Of a total of 989 consecutive patients with COVID-19, 72 (7.2%) had 88 other microbiologically confirmed infections: 74 were bacterial, seven fungal and seven viral. Community-acquired co-infection at COVID-19 diagnosis was uncommon (31/989, 3.1%) and mainly caused by Streptococcus pneumoniae and Staphylococcus aureus. A total of 51 hospital-acquired bacterial superinfections, mostly caused by Pseudomonas aeruginosa and Escherichia coli, were diagnosed in 43 patients (4.7%), with a mean (SD) time from hospital admission to superinfection diagnosis of 10.6 (6.6) days. Overall mortality was 9.8% (97/989). Patients with community-acquired co-infections and hospital-acquired superinfections had worse outcomes. Conclusions Co-infection at COVID-19 diagnosis is uncommon. Few patients developed superinfections during hospitalization. These findings are different compared to those of other viral pandemics. As it relates to hospitalized patients with COVID-19, such findings could prove essential in defining the role of empiric antimicrobial therapy or stewardship strategies.

Topik & Kata Kunci

Medicine

Penulis (45)

C. García-Vidal

Gemma Sanjuán

E. Moreno-García

P. Puerta-Alcalde

Nicole García-Poutón

M. Chumbita

Mariana Fernández-Pittol

C. Pitart

A. Inciarte

M. Bodro

L. Morata

J. Ambrosioni

I. Grafia

F. Meira

I. Macaya

C. Cardozo

C. Casals

A. Téllez

P. Castro

F. Marco

Felipe García

J. Mensa

J. Martinez

Á. Soriano

Verónica Marta Daiana Berta Ana Lorena Jhon Laura Berta Nat Rico Hernández-Meneses Agüero Torres González de l

Verónica Rico

M. Hernández-Meneses

Daiana L. Agüero

B. Torres

Ana González

Lorena de la Mora

J. Rojas

L. Linares

B. Fidalgo

N. Rodríguez

D. Nicolás

Laia Albiach

J. Muñóz

A. Almuedo

D. Camprubí

M. Ángeles Marcos

C. Cillóniz

S. Fernandez

J. Nicolás

A. Torres

Format Sitasi

APA MLA BibTeX

García-Vidal, C., Sanjuán, G., Moreno-García, E., Puerta-Alcalde, P., García-Poutón, N., Chumbita, M. et al. (2020). Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. https://doi.org/10.1016/j.cmi.2020.07.041

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.cmi.2020.07.041

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 787×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.cmi.2020.07.041
Akses: Open Access ✓