Semantic Scholar Open Access 2020 969 sitasi

A reference map of the human binary protein interactome

Katja Luck Dae-Kyum Kim L. Lambourne Kerstin Spirohn Bridget E. Begg +83 lainnya

Lihat Sumber DOI

Abstrak

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype–phenotype relationships1,2. Here we present a human ‘all-by-all’ reference interactome map of human binary protein interactions, or ‘HuRI’. With approximately 53,000 protein–protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome3, transcriptome4 and proteome5 data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein–protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes. A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

Topik & Kata Kunci

Computer Science Medicine Biology

Penulis (88)

Katja Luck

Dae-Kyum Kim

L. Lambourne

Kerstin Spirohn

Bridget E. Begg

Wenting Bian

Ruth Brignall

T. Cafarelli

F. Campos-Laborie

B. Charloteaux

Dongsic Choi

Atina G. Coté

Meaghan C. Daley

Steven J. Deimling

A. Desbuleux

Amélie Dricot

M. Gebbia

M. Hardy

Nishka Kishore

Jennifer J. Knapp

István A. Kovács

I. Lemmens

Miles W. Mee

J. Mellor

Carl Pollis

Carles Pons

Aaron D. Richardson

Sadie Schlabach

Bridget Teeking

Anupama Yadav

Mariana Babor

Dawit Balcha

Omer Basha

Christian Bowman-Colin

S. Chin

Soon-gang Choi

Claudia Colabella

Georges Coppin

Cassandra D’Amata

David de Ridder

S. de Rouck

Miquel Duran-Frigola

Hanane Ennajdaoui

Florian Goebels

Liana J Goehring

Anjali Gopal

Ghazal Haddad

E. Hatchi

M. Helmy

Y. Jacob

Yoseph Kassa

Serena Landini

Roujia Li

N. van Lieshout

A. MacWilliams

D. Markey

J. Paulson

Sudharshan Rangarajan

John Rasla

Ashyad Rayhan

T. Rolland

A. San-Miguel

Yun Shen

Dayag Sheykhkarimli

Gloria M. Sheynkman

Eyal Simonovsky

M. Tasan

Alexander O. Tejeda

V. Tropepe

J. Twizere

Yang Wang

Robert J. Weatheritt

Jochen Weile

Yu Xia

Xinping Yang

Esti Yeger-Lotem

Q. Zhong

P. Aloy

Gary D Bader

J De Las Rivas

S. Gaudet

Tong Hao

J. Rak

J. Tavernier

D. Hill

M. Vidal

F. Roth

M. Calderwood

Format Sitasi

APA MLA BibTeX

Luck, K., Kim, D., Lambourne, L., Spirohn, K., Begg, B.E., Bian, W. et al. (2020). A reference map of the human binary protein interactome. https://doi.org/10.1038/s41586-020-2188-x

@article{luck2020, author = {Katja Luck and Dae-Kyum Kim and L. Lambourne and Kerstin Spirohn and Bridget E. Begg and Wenting Bian and Ruth Brignall and T. Cafarelli and F. Campos-Laborie and B. Charloteaux and Dongsic Choi and Atina G. Coté and Meaghan C. Daley and Steven J. Deimling and A. Desbuleux and Amélie Dricot and M. Gebbia and M. Hardy and Nishka Kishore and Jennifer J. Knapp and István A. Kovács and I. Lemmens and Miles W. Mee and J. Mellor and Carl Pollis and Carles Pons and Aaron D. Richardson and Sadie Schlabach and Bridget Teeking and Anupama Yadav and Mariana Babor and Dawit Balcha and Omer Basha and Christian Bowman-Colin and S. Chin and Soon-gang Choi and Claudia Colabella and Georges Coppin and Cassandra D’Amata and David de Ridder and S. de Rouck and Miquel Duran-Frigola and Hanane Ennajdaoui and Florian Goebels and Liana J Goehring and Anjali Gopal and Ghazal Haddad and E. Hatchi and M. Helmy and Y. Jacob and Yoseph Kassa and Serena Landini and Roujia Li and N. van Lieshout and A. MacWilliams and D. Markey and J. Paulson and Sudharshan Rangarajan and John Rasla and Ashyad Rayhan and T. Rolland and A. San-Miguel and Yun Shen and Dayag Sheykhkarimli and Gloria M. Sheynkman and Eyal Simonovsky and M. Tasan and Alexander O. Tejeda and V. Tropepe and J. Twizere and Yang Wang and Robert J. Weatheritt and Jochen Weile and Yu Xia and Xinping Yang and Esti Yeger-Lotem and Q. Zhong and P. Aloy and Gary D Bader and J De Las Rivas and S. Gaudet and Tong Hao and J. Rak and J. Tavernier and D. Hill and M. Vidal and F. Roth and M. Calderwood}, title = {A reference map of the human binary protein interactome}, year = {2020}, journal = {Semantic Scholar}, doi = {10.1038/s41586-020-2188-x}, url = {https://www.semanticscholar.org/paper/b09e0159bfce50f2305d38aae55bb6dba7196c20}, }

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41586-020-2188-x

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 969×
Sumber Database: Semantic Scholar
DOI: 10.1038/s41586-020-2188-x
Akses: Open Access ✓