Wireless and Closed‐Loop Smart Dressing for Exudate Management and On‐Demand Treatment of Chronic Wounds
Abstrak
Chronic wounds have become a significant threat to people's physical and mental health and have increased the burden of social medical care. Intelligent wound dressing (IWD) with wound condition monitoring and closed‐loop on‐demand drug therapy can shorten the healing process and alleviate patient suffering. However, single‐function wound dressings cannot meet the current needs of chronic wound treatment. Here, a wearable IWD consisting of wound exudate management, sensor monitoring, closed‐loop therapy, and flexible circuit modules is reported, which can achieve effective synergy between wound exudate management and on‐demand wound therapy. The dressing is attached to the wound site, and the wound exudate is spontaneously pumped into the microfluidic channel for storage. Meanwhile, the IWD can detect the state of the wound through the temperature and humidity sensor, and use this as feedback to control the liquid metal (LM) heater through a smartphone, thereby realizing the on‐demand drug release from the hydrogel. In a mouse model of infected wounds, IWD accelerates wound healing by reducing inflammatory responses, promoting angiogenesis and collagen deposition.
Topik & Kata Kunci
Penulis (11)
Zhenyou Ge
Wenshang Guo
Ye Tao
Haoxiu Sun
Xiangyu Meng
Liangyu Cao
Shanguo Zhang
Weiyu Liu
Muhammad Luqman Akhtar
Yu Li
Yukun Ren
Akses Cepat
- Tahun Terbit
- 2023
- Bahasa
- en
- Total Sitasi
- 127×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1002/adma.202304005
- Akses
- Open Access ✓