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Semantic Scholar Open Access 2009 226 sitasi

TRPV1 Is Activated by Both Acidic and Basic pH

A. Dhaka V. Uzzell A. Dubin Jayanti Mathur Matt J. Petrus +2 lainnya
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Abstrak

Maintaining physiological pH is required for survival, and exposure to alkaline chemicals such as ammonia (smelling salts) elicits severe pain and inflammation through unknown mechanisms. TRPV1, the capsaicin receptor, is an integrator of noxious stimuli including heat and extracellular acidic pH. Here, we report that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) expressed in sensory neurons. Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH. Our studies show that TRPV1 detects both acidic and basic deviations from homeostatic pH.

Topik & Kata Kunci

Chemistry Medicine

Penulis (7)

A

A. Dhaka

V

V. Uzzell

A

A. Dubin

J

Jayanti Mathur

M

Matt J. Petrus

M

M. Bandell

A

A. Patapoutian

Format Sitasi

APA MLA BibTeX
Dhaka, A., Uzzell, V., Dubin, A., Mathur, J., Petrus, M.J., Bandell, M. et al. (2009). TRPV1 Is Activated by Both Acidic and Basic pH. https://doi.org/10.1523/JNEUROSCI.4901-08.2009

Akses Cepat

Lihat di Sumber doi.org/10.1523/JNEUROSCI.4901-08.2009
Informasi Jurnal
Tahun Terbit
2009
Bahasa
en
Total Sitasi
226×
Sumber Database
Semantic Scholar
DOI
10.1523/JNEUROSCI.4901-08.2009
Akses
Open Access ✓