Semantic Scholar Open Access 2020 74 sitasi

Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

W. Chao C. Tseng Chieh-Liang Wu Sou-Jen Shih C. Yi +1 lainnya

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Abstrak

Background High glycemic variability (GV) is common in critically ill patients; however, the prevalence and mortality association with early GV in patients with sepsis remains unclear. Methods This retrospective cohort study was conducted in a medical intensive care unit (ICU) in central Taiwan. Patients in the ICU with sepsis between January 2014 and December 2015 were included for analysis. All of these patients received protocol-based management, including blood sugar monitoring every 2 h for the first 24 h of ICU admission. Mean amplitude of glycemic excursions (MAGE) and coefficient of variation (CoV) were used to assess GV. Results A total of 452 patients (mean age 71.4 ± 14.7 years; 76.7% men) were enrolled for analysis. They were divided into high GV (43.4%, 196/452) and low GV (56.6%, 256/512) groups using MAGE 65 mg/dL as the cut-off point. Patients with high GV tended to have higher HbA1c (6.7 ± 1.8% vs. 5.9 ± 0.9%, p 65 mg/dL. Higher GV within 24 h of ICU admission was independently associated with increased 30-day mortality. These findings highlight the need to monitor GV in septic patients early during an ICU admission.

Topik & Kata Kunci

Medicine

Penulis (6)

W. Chao

C. Tseng

Chieh-Liang Wu

Sou-Jen Shih

C. Yi

M. Chan

Format Sitasi

APA MLA BibTeX

Chao, W., Tseng, C., Wu, C., Shih, S., Yi, C., Chan, M. (2020). Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis. https://doi.org/10.1186/s13613-020-0635-3

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Lihat di Sumber doi.org/10.1186/s13613-020-0635-3

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 74×
Sumber Database: Semantic Scholar
DOI: 10.1186/s13613-020-0635-3
Akses: Open Access ✓