Semantic Scholar Open Access 2023 27 sitasi

Human milk oligosaccharides: potential therapeutic aids for allergic diseases.

Isabel Tarrant B. B. Finlay

Abstrak

Childhood allergy, including asthma, eczema, and food allergies, is a major global health burden, with prevalence increasing dramatically and novel interventions needed. Emerging research suggests that human milk oligosaccharides (HMOs), complex glycans found in breastmilk, have allergy-protective properties, indicating exciting therapeutic potential. This review evaluates current literature on the role of HMOs in allergy, assesses underlying immunological mechanisms, and discusses future research needed to translate findings into clinical implications. HMOs may mediate allergy risk through multiple structure-specific mechanisms, including microbiome modification, intestinal barrier maturation, immunomodulation, and gene regulation. Findings emphasize the importance of breastfeeding encouragement and HMO-supplemented formula milk for high allergy-risk infants. Although further investigation is necessary to determine the most efficacious structures against varying allergy phenotypes and their long-term efficacy, HMOs may represent a promising complementary tool for childhood allergy prevention.

Topik & Kata Kunci

Medicine

Penulis (2)

Isabel Tarrant

B. B. Finlay

Format Sitasi

APA MLA BibTeX

Tarrant, I., Finlay, B.B. (2023). Human milk oligosaccharides: potential therapeutic aids for allergic diseases.. https://doi.org/10.1016/j.it.2023.06.003

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Informasi Jurnal

Tahun Terbit: 2023
Bahasa: en
Total Sitasi: 27×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.it.2023.06.003
Akses: Open Access ✓