Genetics of Alzheimer's Disease
Abstrak
Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease.
Topik & Kata Kunci
Penulis (3)
P. Ridge
M. Ebbert
J. Kauwe
Akses Cepat
- Tahun Terbit
- 2013
- Bahasa
- en
- Total Sitasi
- 770×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1155/2013/254954
- Akses
- Open Access ✓