Semantic Scholar Open Access 2015 1477 sitasi

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Willemijn J Jansen R. Ossenkoppele D. Knol B. Tijms P. Scheltens +124 lainnya

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Abstrak

IMPORTANCE Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. OBJECTIVE To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as measured with biomarkers in participants with normal cognition, subjective cognitive impairment (SCI), or mild cognitive impairment (MCI). DATA SOURCES Relevant biomarker studies identified by searching studies published before April 2015 using the MEDLINE and Web of Science databases and through personal communication with investigators. STUDY SELECTION Studies were included if they provided individual participant data for participants without dementia and used an a priori defined cutoff for amyloid positivity. DATA EXTRACTION AND SYNTHESIS Individual records were provided for 2914 participants with normal cognition, 697 with SCI, and 3972 with MCI aged 18 to 100 years from 55 studies. MAIN OUTCOMES AND MEASURES Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations. RESULTS The prevalence of amyloid pathology increased from age 50 to 90 years from 10% (95% CI, 8%-13%) to 44% (95% CI, 37%-51%) among participants with normal cognition; from 12% (95% CI, 8%-18%) to 43% (95% CI, 32%-55%) among patients with SCI; and from 27% (95% CI, 23%-32%) to 71% (95% CI, 66%-76%) among patients with MCI. APOE-ε4 carriers had 2 to 3 times higher prevalence estimates than noncarriers. The age at which 15% of the participants with normal cognition were amyloid positive was approximately 40 years for APOE ε4ε4 carriers, 50 years for ε2ε4 carriers, 55 years for ε3ε4 carriers, 65 years for ε3ε3 carriers, and 95 years for ε2ε3 carriers. Amyloid positivity was more common in highly educated participants but not associated with sex or biomarker modality. CONCLUSIONS AND RELEVANCE Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, APOE genotype, and presence of cognitive impairment. These findings suggest a 20- to 30-year interval between first development of amyloid positivity and onset of dementia.

Topik & Kata Kunci

Medicine

Penulis (129)

Willemijn J Jansen

R. Ossenkoppele

D. Knol

B. Tijms

P. Scheltens

F. Verhey

P. Visser

P. Aalten

D. Aarsland

D. Alcolea

M. Alexander

I. S. Almdahl

S. Arnold

I. Baldeiras

H. Barthel

B. V. van Berckel

K. Bibeau

K. Blennow

D. Brooks

M. van Buchem

V. Camus

E. Cavedo

Kewei Chen

G. Chételat

A. Cohen

A. Drzezga

S. Engelborghs

A. Fagan

T. Fladby

A. Fleisher

W. M. van der Flier

L. Ford

S. Förster

J. Fortea

N. Foskett

K. Frederiksen

Y. Freund-Levi

G. Frisoni

L. Froelich

T. Gabryelewicz

K. Gill

O. Gkatzima

E. Gómez-Tortosa

M. Gordon

T. Grimmer

H. Hampel

L. Hausner

S. Hellwig

S. Herukka

H. Hildebrandt

L. Ishihara

A. Ivanoiu

W. Jagust

P. Johannsen

R. Kandimalla

E. Kapaki

A. Klimkowicz-Mrowiec

W. Klunk

S. Köhler

N. Koglin

J. Kornhuber

M. Kramberger

K. Van Laere

Susan M. Landau

D. Y. Lee

M. D. de Leon

Viviana Lisetti

A. Lleó

K. Madsen

W. Maier

J. Marcusson

N. Mattsson

A. de Mendonça

O. Meulenbroek

P. Meyer

M. Mintun

V. Mok

J. Molinuevo

H. M. Møllergård

J. Morris

B. Mroczko

Stefan Van der Mussele

D. Na

A. Newberg

A. Nordberg

A. Nordlund

G. Novak

G. Paraskevas

L. Parnetti

G. Perera

O. Peters

J. Popp

S. Prabhakar

G. Rabinovici

I. Ramakers

L. Rami

Catarina Resende de Oliveira

J. Rinne

K. Rodrigue

E. Rodríguez-Rodríguez

C. Roe

U. Rot

C. Rowe

E. Rüther

O. Sabri

P. Sánchez-Juan

I. Santana

M. Sarazin

J. Schröder

Christin Schütte

S. Seo

F. Soetewey

H. Soininen

L. Spiru

H. Struyfs

C. Teunissen

M. Tsolaki

R. Vandenberghe

M. Verbeek

V. Villemagne

S. Vos

L. J. van Waalwijk van Doorn

G. Waldemar

Anders Wallin

Å. Wallin

J. Wiltfang

D. Wolk

M. Zboch

H. Zetterberg

Format Sitasi

APA MLA BibTeX

Jansen, W.J., Ossenkoppele, R., Knol, D., Tijms, B., Scheltens, P., Verhey, F. et al. (2015). Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.. https://doi.org/10.1001/jama.2015.4668

@article{jansen2015, author = {Willemijn J Jansen and R. Ossenkoppele and D. Knol and B. Tijms and P. Scheltens and F. Verhey and P. Visser and P. Aalten and D. Aarsland and D. Alcolea and M. Alexander and I. S. Almdahl and S. Arnold and I. Baldeiras and H. Barthel and B. V. van Berckel and K. Bibeau and K. Blennow and D. Brooks and M. van Buchem and V. Camus and E. Cavedo and Kewei Chen and G. Chételat and A. Cohen and A. Drzezga and S. Engelborghs and A. Fagan and T. Fladby and A. Fleisher and W. M. van der Flier and L. Ford and S. Förster and J. Fortea and N. Foskett and K. Frederiksen and Y. Freund-Levi and G. Frisoni and L. Froelich and T. Gabryelewicz and K. Gill and O. Gkatzima and E. Gómez-Tortosa and M. Gordon and T. Grimmer and H. Hampel and L. Hausner and S. Hellwig and S. Herukka and H. Hildebrandt and L. Ishihara and A. Ivanoiu and W. Jagust and P. Johannsen and R. Kandimalla and E. Kapaki and A. Klimkowicz-Mrowiec and W. Klunk and S. Köhler and N. Koglin and J. Kornhuber and M. Kramberger and K. Van Laere and Susan M. Landau and D. Y. Lee and M. D. de Leon and Viviana Lisetti and A. Lleó and K. Madsen and W. Maier and J. Marcusson and N. Mattsson and A. de Mendonça and O. Meulenbroek and P. Meyer and M. Mintun and V. Mok and J. Molinuevo and H. M. Møllergård and J. Morris and B. Mroczko and Stefan Van der Mussele and D. Na and A. Newberg and A. Nordberg and A. Nordlund and G. Novak and G. Paraskevas and L. Parnetti and G. Perera and O. Peters and J. Popp and S. Prabhakar and G. Rabinovici and I. Ramakers and L. Rami and Catarina Resende de Oliveira and J. Rinne and K. Rodrigue and E. Rodríguez-Rodríguez and C. Roe and U. Rot and C. Rowe and E. Rüther and O. Sabri and P. Sánchez-Juan and I. Santana and M. Sarazin and J. Schröder and Christin Schütte and S. Seo and F. Soetewey and H. Soininen and L. Spiru and H. Struyfs and C. Teunissen and M. Tsolaki and R. Vandenberghe and M. Verbeek and V. Villemagne and S. Vos and L. J. van Waalwijk van Doorn and G. Waldemar and Anders Wallin and Å. Wallin and J. Wiltfang and D. Wolk and M. Zboch and H. Zetterberg}, title = {Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.}, year = {2015}, journal = {Semantic Scholar}, doi = {10.1001/jama.2015.4668}, url = {https://www.semanticscholar.org/paper/9b19b655eaad033877f715ca1a4eddd6cf881903}, }

Akses Cepat

Lihat di Sumber doi.org/10.1001/jama.2015.4668

Informasi Jurnal

Tahun Terbit: 2015
Bahasa: en
Total Sitasi: 1477×
Sumber Database: Semantic Scholar
DOI: 10.1001/jama.2015.4668
Akses: Open Access ✓