Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks.
Abstrak
Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remain a challenge and missing elements. Herein, utilizing DNA triangular prism (TP) and branched polymer (BP) as functional modules, we fabricate tunable DNA scaffold networks on cell surface. The responsiveness of cell-cell recognition, aggregation and dissociation could be modulated by aptamer-functionalized DNA scaffold networks with high accuracy and specificity. By regulating the DNA scaffold networks coated on cell surface, the controlled intercellular molecular transportation is achieved. Our tunable network provides a simple and extendible strategy which addresses a current need in cell surface engineering to precisely manipulate cell-cell interactions and shows a promise as a general tool for controllable cell behavior.
Topik & Kata Kunci
Penulis (11)
Zhenzhen Guo
Lili Zhang
Qiuxia Yang
Ruizi Peng
Xi Yuan
Liujun Xu
Zhimin Wang
Fengming Chen
Huidong Huang
Qiaoling Liu
Weihong Tan
Akses Cepat
- Tahun Terbit
- 2021
- Bahasa
- en
- Total Sitasi
- 36×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1002/anie.202111151
- Akses
- Open Access ✓