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Semantic Scholar Open Access 2020 84 sitasi

Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems.

V. Rapalli Tejashree Waghule Srividya Gorantla S. Dubey R. Saha +1 lainnya
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Abstrak

Psoriasis is a chronic autoimmune skin disorder triggered by either genetic factors, environmental factors, life style, or a combination thereof. Clinical investigations have identified pathogenesis, such as T cell and cytokine-mediated, genetic disposition, antimicrobial peptides, lipocalin-2, galectin-3, vaspin, fractalkine, and human neutrophil peptides in the progression of psoriasis. In addition to traditional therapies, newer therapeutics, including phosphodiesterase type 4 (PDE4) inhibitors, Janus kinase (JAK) inhibitors, monoclonal antibodies (mAbs), gene therapy, anti-T cell therapy, and phytoconstituents have been explored. In this review, we highlight nanotechnology-related developments for psoriasis treatment, including patented delivery systems and therapeutics currently in clinical trials.

Topik & Kata Kunci

Medicine

Penulis (6)

V

V. Rapalli

T

Tejashree Waghule

S

Srividya Gorantla

S

S. Dubey

R

R. Saha

G

Gautam Singhvi

Format Sitasi

APA MLA BibTeX
Rapalli, V., Waghule, T., Gorantla, S., Dubey, S., Saha, R., Singhvi, G. (2020). Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems.. https://doi.org/10.1016/j.drudis.2020.09.023

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Lihat di Sumber doi.org/10.1016/j.drudis.2020.09.023
Informasi Jurnal
Tahun Terbit
2020
Bahasa
en
Total Sitasi
84×
Sumber Database
Semantic Scholar
DOI
10.1016/j.drudis.2020.09.023
Akses
Open Access ✓