Semantic Scholar
Open Access
2014
421 sitasi
Bright Building Blocks for Chemical Biology
L. Lavis
Ronald T. Raines
Abstrak
Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol.2008, 3, 142–155), the extant collection of fluorescent probes is built on a modest set of “core” scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists.
Penulis (2)
L
L. Lavis
R
Ronald T. Raines
Akses Cepat
Informasi Jurnal
- Tahun Terbit
- 2014
- Bahasa
- en
- Total Sitasi
- 421×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1021/cb500078u
- Akses
- Open Access ✓