Semantic Scholar Open Access 2019 272 sitasi

Fiery Cell Death: Pyroptosis in the Central Nervous System.

Brienne A. McKenzie V. Dixit C. Power

Abstrak

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs downstream of inflammasome activation. Pyroptosis is mediated directly by the recently identified family of pore-forming proteins known as gasdermins, the best characterized of which is gasdermin D (GSDMD). Recent investigations implicate pyroptosis in the pathogenesis of multiple neurological diseases. In this review, we discuss molecular mechanisms that drive pyroptosis, evidence for pyroptosis within the CNS, and emerging therapeutic strategies for its inhibition in the context of neurological disease.

Topik & Kata Kunci

Biology Medicine

Penulis (3)

Brienne A. McKenzie

V. Dixit

C. Power

Format Sitasi

APA MLA BibTeX

McKenzie, B.A., Dixit, V., Power, C. (2019). Fiery Cell Death: Pyroptosis in the Central Nervous System.. https://doi.org/10.1016/j.tins.2019.11.005

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.1016/j.tins.2019.11.005

Informasi Jurnal

Tahun Terbit: 2019
Bahasa: en
Total Sitasi: 272×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.tins.2019.11.005
Akses: Open Access ✓